Výsledky vyhledávání - "David Sibrac"

Akademický článek

Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis

Autor: Stéphane Gesta, Marie-Françoise Simon, Astrid Rey, David Sibrac, Alexia Girard, Max Lafontan, Philippe Valet, Jean Sébastien Saulnier-Blache

Publikováno v: Journal of Lipid Research, Vol 43, Iss 6, Pp 904-910 (2002)

The aim of the present work was to depict the metabolic pathways involved in extracellular production of lysophosphatidic acid (LPA) by adipocytes. LPA was followed by quantifying the accumulation of LPA in the incubation medium (conditioned medium,

Externí odkaz: https://doaj.org/article/85e54548da144661adb5aaf4643f922b

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Supplementary Materials and Methods SM1 from Targeting Tumor Angiogenesis with the Selective VEGFR-3 Inhibitor EVT801 in Combination with Cancer Immunotherapy

supplementary materials & methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aab200c02df34d0037f10e9a77fdaa8
https://doi.org/10.1158/2767-9764.22546302

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Supplementary Figure S8 from Targeting Tumor Angiogenesis with the Selective VEGFR-3 Inhibitor EVT801 in Combination with Cancer Immunotherapy

Supplementary Figure S8 shows that EVT801 doesn’t modify blood pressure in rat while sorafenib increases it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54437c04f35665bb180f58aab83e2bf2
https://doi.org/10.1158/2767-9764.22546308.v1

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Supplementary Table TS2 from Targeting Tumor Angiogenesis with the Selective VEGFR-3 Inhibitor EVT801 in Combination with Cancer Immunotherapy

Supplementary Table S2 shows EVT801 metabolite potency and selectivity profile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b6b7b7adb54bd4580df39014d631a7
https://doi.org/10.1158/2767-9764.22546296

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Automated Image Analysis of In Vitro Angiogenesis Assay

Autor: Corinne Michaux, Keith Neil, Josette Desjobert, Bruno Gautret, Corentin Herbert, Hugues Talbot, Anne-Laure Nestor, David Sibrac, Lionel Cousseins, Jean-Pascal Herault, Pierre Fons, Françoise Bono, Marie-Laure Boizeau

Publikováno v: SLAS Technology. 18:411-415

Angiogenesis is the biological process of generating new capillary blood vessels. It is a fundamental component of a number of normal (reproduction and wound healing) and pathological processes (diabetic retinopathy, rheumatoid arthritis, tumor growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36346a0dcf3752ee711579adbb4c27ef
https://doi.org/10.1177/2211068213495204

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Expression of Ectolipid Phosphate Phosphohydrolases in 3T3F442A Preadipocytes and Adipocytes

Autor: Marie Francoise Simon, Philippe Valet, Sandra Grès, Isabelle Castan-Laurel, Jean Sébastien Saulnier-Blache, Astrid Rey, David Sibrac

Publikováno v: Journal of Biological Chemistry. 277:23131-23136

Because of its production by adipocytes and its ability to increase preadipocyte proliferation, lysophosphatidic acid (LPA) could participate in the paracrine control of adipose tissue development. The aim of the present study was to determine which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67a235d0efad5ae0ba685eebdf8fa4e3
https://doi.org/10.1074/jbc.m201530200

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Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

Autor: Francesco Luigi Gervasio, Filip Claes, Massimiliano Mazzone, Koen Poesen, Jef Rozensky, Jean-Pascal Herault, David Sibrac, Silvia Blacher, Pierre Fons, Corentin Herbert, Frederik De Smet, Isabelle Blanc, Chantal Alcouffe, Christof Michielsen, Corinne Michaux, Patrice Rigon, Jean-Marie Rakic, Patrick Motte, Avner Yayon, Ann Van Schepdael, Jie Zhang, Agnès Noël, Geert Carmeliet, Susumu Katsuma, Roselyne Broussy, Inmaculada Segura, Peter Carmeliet, Toru Shimada, Françoise Bono, Harald Schwalbe, Geneviève Gueguen, Marie-Françoise Bordes, Carmen Ruiz de Almodovar, Annelii Ny, Eran Rom, Katrien De Bock, Christian Fischer, Maria Georgiadou, Frédérique Dol-Gleizes, Masahiro Murakami, Mieke Dewerchin, Anthony A. Lanahan, Serena Zacchigna, Bart Jonckx, Arthur Christopoulos, Marlies Van de Wouwer, Marc Tjwa, Marc Bianciotto, Michael Simons, Jean-Marc Herbert, Isabelle Jean, Paul Schaeffer, Diether Lambrechts

Publikováno v: Cancer Cell

SummaryReceptor tyrosine kinases (RTK) are targets for anticancer drug development. To date, only RTK inhibitors that block orthosteric binding of ligands and substrates have been developed. Here, we report the pharmacologic characterization of the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5b8b8397276447617a5d0be2181975
https://hdl.handle.net/11368/2897461

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Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements

Autor: Philippe Valet, Isabelle Castan-Laurell, Isabelle Dugail, S. Le Lay, Jeremie Boucher, Stéphane Krief, Max Lafontan, Bradford B. Lowell, Danica Grujic, David Sibrac, Jean-Sébastien Saulnier-Blache

Publikováno v: Journal of molecular endocrinology. 29(2)

Catecholamines regulate white adipose tissue function and development by acting through beta- and alpha2-adrenergic receptors (ARs). Human adipocytes express mainly alpha 2A- but few or no beta 3-ARs while the reverse is true for rodent adipocytes. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f2e33055b553ec861630629cb3af21
https://pubmed.ncbi.nlm.nih.gov/12370125

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