Zobrazeno 1 - 10
of 471
pro vyhledávání: '"David Sibley"'
Autor:
Muxiao Li, Fuxian Yang, Tianyi Hou, Xiaoqing Gong, Na Li, L. David Sibley, Yaoyu Feng, Lihua Xiao, Yaqiong Guo
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Biological studies of the determinants of Cryptosporidium infectivity are lacking despite the fact that cryptosporidiosis is a major public health problem. Recently, the 60-kDa glycoprotein (GP60) has received attention because of its high s
Externí odkaz:
https://doaj.org/article/0dbca9c304d149199cfe4c75d1a72101
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT In both mice and humans, Type II interferon gamma (IFNγ) is crucial for the regulation of Toxoplasma gondii (T. gondii) infection, during acute or chronic phases. To thwart this defense, T. gondii secretes protein effectors hindering the ho
Externí odkaz:
https://doaj.org/article/03e35d06cafa44b5841a8ea8a7076d19
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT Toxoplasma gondii bradyzoites play a critical role in pathology due to their long-term persistence in intermediate hosts and their potential to reactivate, resulting in severe diseases in immunocompromised individuals. Currently, there is no
Externí odkaz:
https://doaj.org/article/b0725fc71fad475b8de6f94f08b232c2
Autor:
Valentin Greigert, Iti Saraav, Juhee Son, Yinxing Zhu, Denise Dayao, Avan Antia, Saul Tzipori, William H. Witola, Thaddeus S. Stappenbeck, Siyuan Ding, L. David Sibley
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTCryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor settings. The majority of infections are caused by the human-specific pathogen C. hominis and absence of in vitro growth platforms has limited our un
Externí odkaz:
https://doaj.org/article/423709fcf24243cba0cbfe768d74d5db
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cryptosporidium parvum is an obligate intracellular parasite with a highly reduced mitochondrion that lacks the tricarboxylic acid cycle and the ability to generate ATP, making the parasite reliant on glycolysis. Genetic ablation experiments
Externí odkaz:
https://doaj.org/article/80bead237d6c45e1bfd20e6581d7ef4b
Autor:
Nicholas Rinkenberger, Alex Rosenberg, Joshua B. Radke, Jaya Bhushan, Tadakimi Tomita, Louis M. Weiss, L. David Sibley
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTAutophagy contributes to innate immunity by targeting intracellular pathogens for elimination. Previous studies identified a non-canonical autophagy pathway that controls Toxoplasma gondii infection in a strain-dependent manner in interferon
Externí odkaz:
https://doaj.org/article/403ad9e259624f7c9a296a7404b85e69
Autor:
Michael R. McAllaster, Jaya Bhushan, Dale R. Balce, Anthony Orvedahl, Arnold Park, Seungmin Hwang, Meagan E. Sullender, L. David Sibley, Herbert W. Virgin
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTGenes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct and physiologically important cellular processes. Some functions of ATG genes are independent of their role in degradative autophagy. O
Externí odkaz:
https://doaj.org/article/ee73c35548d94fc394c27a7238cc9bbd
Autor:
Wenyan Wan, Hui Dong, De-Hua Lai, Jiong Yang, Kai He, Xiaoyan Tang, Qun Liu, Geoff Hide, Xing-Quan Zhu, L. David Sibley, Zhao-Rong Lun, Shaojun Long
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Toxoplasma gondii acquires host cytosolic materials, yet the mechanism remains unknown. Wan et al. reveal the micropore as an essential organelle at the plasma membrane for endocytosis of host cytosolic proteins and biotin, and Golgi ceramide.
Externí odkaz:
https://doaj.org/article/c20394fc9378424aad96f749b94f2e74
Autor:
Aarti Pant, Xiaomin Yao, Aude Lavedrine, Christophe Viret, Jacob Dockterman, Swati Chauhan, Chong-Shan Shi, Ravi Manjithaya, Ken Cadwell, Thomas A. Kufer, John H. Kehrl, Jörn Coers, L. David Sibley, Mathias Faure, Gregory A. Taylor, Santosh Chauhan
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 438-515 (2022)
Autophagy is a highly conserved process that utilizes lysosomes to selectively degrade a variety of intracellular cargo, thus providing quality control over cellular components and maintaining cellular regulatory functions. Autophagy is triggered by
Externí odkaz:
https://doaj.org/article/ededc1436aa54be2b91d4027a2d2bcfe
Autor:
Jin-Lei Wang, Ting-Ting Li, Hany M. Elsheikha, Qin-Li Liang, Zhi-Wei Zhang, Meng Wang, L. David Sibley, Xing-Quan Zhu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Protein phosphorylation and dephosphorylation are essential aspects of biology. Wang et al., report that Toxoplasma gondiiprotein phosphatase 2A (PP2A) mediated dephosphorylation is critical for starch metabolism and bradyzoite differentiation.
Externí odkaz:
https://doaj.org/article/7f82e55342d84b79904c1f1e0b2aaa28