Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David Shackelford"'
Autor:
Yazeed Alhiyari, Jundong Shao, Albert Y. Han, Amanda Miller, Jeffrey F. Krane, Marie Luff, Milica Momcilovic, David Shackelford, Zhen Gu, Maie A. St. John
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Head and neck cancer is the sixth most common cancer in the world, with more than 300,000 deaths attributed to the disease annually. Aggressive surgical resection often with adjuvant chemoradiation is the cornerstone of treatment. However, t
Externí odkaz:
https://doaj.org/article/9d07aca2b824450bb85a66858d5c92ec
Autor:
Claudio Scafoglio, Gihad Abdelhady, Jie Liu, Jane Yanagawa, Dean Wallace, Jorge Barrio, Steven Dubinett, David Shackelford
Publikováno v:
Journal of Clinical and Translational Science, Vol 2, Pp 27-28 (2018)
OBJECTIVES/SPECIFIC AIMS: Lung cancer claims 160,000 lives in the United States every year, and lung adenocarcinoma (LADC) is the most frequent type. Early diagnosis is crucial. Computed tomography (CT) is very sensitive in identifying early-stage lu
Externí odkaz:
https://doaj.org/article/1361de204d314932a361ee7640c1113e
Autor:
Lin Lin, Neal Patel, Blake Wilde, Lucia Fernandez-del-Rio, Eirini Christodoulou, Shinji Ohtake, Randy Caliliw, Orian Shirihai, Xiaowu Gai, Heather Christofk, David Shackelford, Brian Shuch
Publikováno v:
Journal of Urology. 209
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 2080K, Tunable expression of EGFRvIII in genetically modified models correlates with autophagy induction upon CC214-1 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2b1de3c6f56240d0579ff3504b6433
https://doi.org/10.1158/1078-0432.22449398.v1
https://doi.org/10.1158/1078-0432.22449398.v1
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 91K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3483c43cdc5efa5c2dd4ef44b7922c81
https://doi.org/10.1158/1078-0432.22449386.v1
https://doi.org/10.1158/1078-0432.22449386.v1
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 5300K, CC214-1 synergizes at low doses with rapamycin. Quantification of the blots shown in Fig. 2B. PTEN detection on DEAL captured GBM39 cells upon CC214-1 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcdf12758410788442ca9cf00c17376
https://doi.org/10.1158/1078-0432.22449410.v1
https://doi.org/10.1158/1078-0432.22449410.v1
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 3457K, Time course dependent CC214-1 treatment in a panel of isogenic GBM cell lines, U87EGFRvIII, U251 and LN229.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da82c4a2ffcb501586d0dac3aeee2a6
https://doi.org/10.1158/1078-0432.22449413
https://doi.org/10.1158/1078-0432.22449413
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 1554K, Cap-dependent translation is enhanced by EGFRvIII expression and CC214-1 strongly inhibits P-4E-BP1 phosphorylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2f0aac75d15fcc139168fff3b12696
https://doi.org/10.1158/1078-0432.22449404
https://doi.org/10.1158/1078-0432.22449404
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 2561K, Treatment with CC214-1, leads to induction of autophagy in GBM39 cells and genetic inhibition of autophagy sensitizes U87EGFRvIII cells to apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8647dddc84f5c6d5a2c519d64501d378
https://doi.org/10.1158/1078-0432.22449395.v1
https://doi.org/10.1158/1078-0432.22449395.v1
Autor:
Paul S. Mischel, Timothy F. Cloughesy, Rajesh Chopra, Kristen Hege, James R. Heath, Guido Kroemer, C. David James, Frank B. Furnari, Webster K. Cavenee, Heather K. Raymon, Shuichan Xu, Deborah S. Mortensen, Bruno Bonetti, Yuchao Gu, Alvaro Assuncao, Kelly Lin, David Akhavan, Ivan Babic, Kazuhiro Tanaka, Shaojun Zhu, David Shackelford, Genaro R. Villa, David Nathanson, Huijun Yang, Shiro Ikegami, Kenta Masui, Tomoo Matsutani, Deliang Guo, Ciro Zanca, Beatrice Gini
PDF file - 5321K, In vitro and in vivo pharmacological inhibition of autophagy sensitizes U87EGFRvIII cells and orthotopic xenografts to CC214-1/CC214-2 mediated apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6c8d8bf85d619d92452068ce6bc33f
https://doi.org/10.1158/1078-0432.22449392.v1
https://doi.org/10.1158/1078-0432.22449392.v1