Zobrazeno 1 - 5
of 5
pro vyhledávání: '"David Schuftan"'
Autor:
Jingxuan Guo, Huanzhu Jiang, David Schuftan, Jonathan D. Moreno, Ghiska Ramahdita, Lavanya Aryan, Druv Bhagavan, Jonathan Silva, Nathaniel Huebsch
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109954- (2024)
Summary: Hypertension is a major cause of morbidity and mortality in patients with hypertrophic cardiomyopathy (HCM), suggesting a potential role for mechanics in HCM pathogenesis. Here, we developed an in vitro physiological model to investigate how
Externí odkaz:
https://doaj.org/article/35f0bd6352214576a41ec5a3d3f50080
Autor:
Zain Clapacs, Sydney Neal, David Schuftan, Xiaohong Tan, Huanzhu Jiang, Jingxuan Guo, Jai Rudra, Nathaniel Huebsch
Publikováno v:
Gels, Vol 7, Iss 3, p 101 (2021)
Cell encapsulating scaffolds are necessary for the study of cellular mechanosensing of cultured cells. However, conventional scaffolds used for loading cells in bulk generally fail at low compressive strain, while hydrogels designed for high toughnes
Externí odkaz:
https://doaj.org/article/9aad246b5bba4ee5bbef54e5de20973d
Autor:
Kasoorelope Oguntuyo, David Schuftan, Jingxuan Guo, Daniel Simmons, Druv Bhagavan, Jonathan D. Moreno, Po Wei Kang, Evan Miller, Jonathan R. Silva, Nathaniel Huebsch
Publikováno v:
Tissue Engineering Part C: Methods. 28:457-468
Drugs are often removed from clinical trials or market progression owing to their unforeseen effects on cardiac action potential and calcium handling. Induced pluripotent stem cell-derived cardiomyocytes and tissues fabricated from these cells are pr
Autor:
Brennan Kandalaft, Ghiska Ramahdita, Daniel W. Simmons, Guy M. Genin, Brandon Rios, Kasoorelope Oguntuyo, Missy Pear, David Schuftan, Spencer P. Lake, Nathaniel Huebsch, Huanzhu Jiang, Mary K. Munsell, Jingxuan Guo
Publikováno v:
ACS biomaterials scienceengineering. 7(7)
Mechanical loading plays a critical role in cardiac pathophysiology. Engineered heart tissues derived from human induced pluripotent stem cells (iPSCs) allow rigorous investigations of the molecular and pathophysiological consequences of mechanical c
Autor:
Mary K. Munsell, Daniel W. Simmons, Kasoorelope Oguntuyo, Jingxuan Guo, Missy Pear, Brandon Rios, David Schuftan, Nathaniel Huebsch
Publikováno v:
Hypertension. 76
Mechanical loading (e.g. blood pressure) is a critical component of heart disease. Here, we developed a simple, scalable iPSC-derived micro heart muscle (μHM) model by grafting μHM on elastomeric substrates with different stiffnesses to simulate af