Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David Schram"'
Autor:
Jonas Wohlfarth, Corinna Kosnopfel, Dominic Faber, Marion Berthold, Claudia Siedel, Melissa Bernhardt, Andreas Schlosser, Tyler Aprati, David Liu, David Schrama, Roland Houben, Dirk Schadendorf, Matthias Goebeler, Svenja Meierjohann, Bastian Schilling
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2449-2470 (2024)
Immunotherapy has achieved tremendous success in melanoma. However, only around 50% of advanced melanoma patients benefit from immunotherapy. Cyclin‐dependent kinase inhibitor 2A (CDKN2A), encoding the two tumor‐suppressor proteins p14ARF and p16
Externí odkaz:
https://doaj.org/article/329322a45f3c4cab9aaa97867023c73c
Autor:
Corinna Kosnopfel, Simone Wendlinger, Heike Niessner, Johannes Siewert, Tobias Sinnberg, Angelika Hofmann, Jonas Wohlfarth, David Schrama, Marion Berthold, Claudia Siedel, Birgit Sauer, Aarthi Jayanthan, Georg Lenz, Sandra E. Dunn, Bastian Schilling, Birgit Schittek
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background The mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has proved to be an efficient treatment option for cases harboring BRAFV600 mutations (BRAFMut). H
Externí odkaz:
https://doaj.org/article/0723a98be8b54729b41f40fee5a42d27
Autor:
Thilo Gambichler, David Schrama, Riina Käpynen, Sera S. Weyer-Fahlbusch, Jürgen C. Becker, Laura Susok, Florian Kreppel, Nessr Abu Rached
Publikováno v:
Vaccines, Vol 12, Iss 5, p 533 (2024)
Merkel cell carcinoma is a rare, aggressive skin cancer that mainly occurs in elderly and immunocompromised patients. Due to the success of immune checkpoint inhibition in MCC, the importance of immunotherapy and vaccines in MCC has increased in rece
Externí odkaz:
https://doaj.org/article/aca935283e7842faa73199b2bef58659
Publikováno v:
ACS Symposium Series ISBN: 9780841235182
Molecular Markers in Environmental Geochemistry
Molecular Markers in Environmental Geochemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::818ed4990a2608b85c92ef3e30a2dfe5
https://doi.org/10.1021/bk-1997-0671.ch002
https://doi.org/10.1021/bk-1997-0671.ch002
Autor:
Nadera Ahmadzai, Wei Cheng, Dianna Wolfe, Jamie Bonaparte, David Schramm, Elizabeth Fitzpatrick, Vincent Lin, Becky Skidmore, Leila Esmaeilisaraji, Shaun Kilty, Brian Hutton
Publikováno v:
Systematic Reviews, Vol 8, Iss 1, Pp 1-8 (2019)
Abstract Background Hearing loss is one of the leading causes of disability in Canada and worldwide, with more than one million Canadians enduring a hearing-related disability. Meniere’s disease (MD) is a chronic condition of the inner ear, manifes
Externí odkaz:
https://doaj.org/article/585a57434ce84557a09b4c58bf9a3d0a
Autor:
Mark Bastianelli, Amy E. Mark, Arran McAfee, David Schramm, Renée Lefrançois, Matthew Bromwich
Publikováno v:
Journal of Otolaryngology - Head and Neck Surgery, Vol 48, Iss 1, Pp 1-9 (2019)
Abstract Background There is evidence to suggest that rates of hearing loss are increasing more rapidly than the capacity of traditional audiometry resources for screening. A novel innovation in tablet, self-administered portable audiometry has been
Externí odkaz:
https://doaj.org/article/0839b89cd20145f791c66086ff3d6cfc
Autor:
Alexander Thiem, Sonja Hesbacher, Hermann Kneitz, Teresa di Primio, Markus V. Heppt, Heike M. Hermanns, Matthias Goebeler, Svenja Meierjohann, Roland Houben, David Schrama
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-15 (2019)
Abstract Background Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associated with better cl
Externí odkaz:
https://doaj.org/article/f763bb8e779141d8a8d6767b053ede39
Autor:
Marion Wobser, Alexandra Weber, Amelie Glunz, Saskia Tauch, Kristina Seitz, Tobias Butelmann, Sonja Hesbacher, Matthias Goebeler, René Bartz, Hella Kohlhof, David Schrama, Roland Houben
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach. Here, we compared the mode of action of romidepsin (FK228), an establi
Externí odkaz:
https://doaj.org/article/a44783db4f2242dd9008d5dd78ff5fa5
Autor:
Nadera Ahmadzai, Wei Cheng, Shaun Kilty, Leila Esmaeilisaraji, Dianna Wolfe, James Bonaparte, David Schramm, Elizabeth Fitzpatrick, Vincent Lin, Becky Skidmore, Brian Hutton
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0237523 (2020)
BackgroundMeniere's disease (MD) is a chronic condition of the inner ear consisting of symptoms that include vertigo attacks, fluctuating sensorineural hearing loss, tinnitus and aural fullness. Despite availability of various interventions, there is
Externí odkaz:
https://doaj.org/article/5842abc1250a4ab8a48fd11dd97694dc
Autor:
Nadera Ahmadzai, Shaun Kilty, Dianna Wolfe, Jamie Bonaparte, David Schramm, Elizabeth Fitzpatrick, Vincent Lin, Wei Cheng, Becky Skidmore, David Moher, Brian Hutton
Publikováno v:
Systematic Reviews, Vol 7, Iss 1, Pp 1-8 (2018)
Abstract Background Hearing loss is one of the leading causes of disability worldwide, with greater than 20% of Canadian adults having measurable hearing loss in at least one ear. Patients with hearing loss experience impaired quality of life, and em
Externí odkaz:
https://doaj.org/article/1b25d0314c4d4f77a03992d61c9b36b8