Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David Scheibner"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract As immunohistochemistry is valuable for determining tissue and cell tropism of avian influenza viruses (AIV), but time-consuming, an artificial intelligence-based workflow was developed to automate the AIV antigen quantification. Organ sampl
Externí odkaz:
https://doaj.org/article/d30b247122d045829a6b3d904d51f520
Autor:
Luise Hohensee, David Scheibner, Alexander Schäfer, Holly Shelton, Thomas C. Mettenleiter, Angele Breithaupt, Anca Dorhoi, Elsayed M. Abdelwhab, Ulrike Blohm
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-17 (2024)
Abstract Avian influenza viruses (AIV) of the H7N7 subtype are enzootic in the wild bird reservoir in Europe, cause infections in poultry, and have sporadically infected humans. The non-structural protein PB1-F2 is encoded in a second open frame in t
Externí odkaz:
https://doaj.org/article/fe4ccd2d89884908bf60643b5731c604
Autor:
Luise Hohensee, David Scheibner, Christine Luttermann, Holly Shelton, Anca Dorhoi, Elsayed M. Abdelwhab, Ulrike Blohm
Publikováno v:
Virus Research, Vol 349, Iss , Pp 199444- (2024)
Avian influenza viruses (AIV) pose a continuous challenge to global health and economy. While countermeasures exist to control outbreaks in poultry, the persistent circulation of AIV in wild aquatic and shorebirds presents a significant challenge to
Externí odkaz:
https://doaj.org/article/94ac0699234b4f198847010dcc06f20c
Autor:
David Scheibner, Ahmed H Salaheldin, Ola Bagato, Luca M Zaeck, Ahmed Mostafa, Ulrike Blohm, Christin Müller, Ahmed F Eweas, Kati Franzke, Axel Karger, Alexander Schäfer, Marcel Gischke, Donata Hoffmann, Solène Lerolle, Xuguang Li, Hatem S Abd El-Hamid, Jutta Veits, Angele Breithaupt, Geert-Jan Boons, Mikhail Matrosovich, Stefan Finke, Stephan Pleschka, Thomas C Mettenleiter, Robert P de Vries, Elsayed M Abdelwhab
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011135 (2023)
Global spread and regional endemicity of H5Nx Goose/Guangdong avian influenza viruses (AIV) pose a continuous threat for poultry production and zoonotic, potentially pre-pandemic, transmission to humans. Little is known about the role of mutations in
Externí odkaz:
https://doaj.org/article/5e67914c60d94bd3bdd8f58ed3fa88db
Autor:
Marcel Gischke, Ola Bagato, Angele Breithaupt, David Scheibner, Claudia Blaurock, Melina Vallbracht, Axel Karger, Beate Crossley, Jutta Veits, Eva Böttcher-Friebertshäuser, Thomas C. Mettenleiter, Elsayed M. Abdelwhab
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 666-678 (2021)
To date, only low pathogenic (LP) H5 and H7 avian influenza viruses (AIV) have been observed to naturally shift to a highly pathogenic (HP) phenotype after mutation of the monobasic hemagglutinin (HA) cleavage site (HACS) to polybasic motifs. The LPA
Externí odkaz:
https://doaj.org/article/6ce905d0851a4206b81dab801d2c15f7
Autor:
Claudia Blaurock, Ulrike Blohm, Christine Luttermann, Julia Holzerland, David Scheibner, Alexander Schäfer, Allison Groseth, Thomas C. Mettenleiter, Elsayed M. Abdelwhab
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1760-1776 (2021)
Avian influenza viruses (AIV) H5N8 clade 2.3.4.4 pose a public health threat but the viral factors relevant for its potential adaptation to mammals are largely unknown. The non-structural protein 1 (NS1) of influenza viruses is an essential interfero
Externí odkaz:
https://doaj.org/article/c436e6b0a5fb428c811db2df35764c38
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-7 (2019)
Abstract Background There is paucity of data on the virulence of highly pathogenic (HP) avian influenza viruses (AIV) H7 in ducks compared to HPAIV H5. Here, the virulence of HPAIV H7N1 (designated H7N1-FPV34 and H7N1-It99) and H7N7 (designated H7N7-
Externí odkaz:
https://doaj.org/article/4aa6b550b58b4bc7b37dcf8214d85972
Autor:
Annika Graaf, Reiner Ulrich, Pavlo Maksimov, David Scheibner, Susanne Koethe, Elsayed M. Abdelwhab, Thomas C. Mettenleiter, Martin Beer, Timm Harder
Publikováno v:
Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-12 (2018)
Abstract Highly pathogenic avian influenza virus (HPAIV) infection in poultry caused devastating mortality and economic losses. HPAIV of subtypes H5 and H7 emerge from precursor viruses of low pathogenicity (LP) by spontaneous mutation associated wit
Externí odkaz:
https://doaj.org/article/d188cc9cf5da4e2b8c0d77866c0fe0fa
Autor:
Maria Landmann, David Scheibner, Annika Graaf, Marcel Gischke, Susanne Koethe, Olanrewaju I. Fatola, Barbara Raddatz, Thomas C. Mettenleiter, Martin Beer, Christian Grund, Timm Harder, Elsayed M. Abdelwhab, Reiner Ulrich
Publikováno v:
Viruses, Vol 13, Iss 5, p 868 (2021)
The main findings of the post-mortem examination of poultry infected with highly pathogenic avian influenza viruses (HPAIV) include necrotizing inflammation and viral antigen in multiple organs. The lesion profile displays marked variability, dependi
Externí odkaz:
https://doaj.org/article/648b431564bb415087008bbf60a9c94e
Autor:
Luca M. Zaeck, David Scheibner, Julia Sehl, Martin Müller, Donata Hoffmann, Martin Beer, Elsayed M. Abdelwhab, Thomas C. Mettenleiter, Angele Breithaupt, Stefan Finke
Publikováno v:
Viruses, Vol 13, Iss 3, p 529 (2021)
The visualization of viral pathogens in infected tissues is an invaluable tool to understand spatial virus distribution, localization, and cell tropism in vivo. Commonly, virus-infected tissues are analyzed using conventional immunohistochemistry in
Externí odkaz:
https://doaj.org/article/2a981cd7d8914797bc7d0f1bad3f1350