Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David Scalzo"'
Autor:
Amy R Strom, Ronald J Biggs, Edward J Banigan, Xiaotao Wang, Katherine Chiu, Cameron Herman, Jimena Collado, Feng Yue, Joan C Ritland Politz, Leah J Tait, David Scalzo, Agnes Telling, Mark Groudine, Clifford P Brangwynne, John F Marko, Andrew D Stephens
Publikováno v:
eLife, Vol 10 (2021)
Chromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus. Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromati
Externí odkaz:
https://doaj.org/article/7e515497572943718908128a28128049
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
The nuclei of differentiating cells exhibit several fundamental principles of self‐organization. They are composed of many dynamical units connected physically and functionally to each other—a complex network—and the different parts of the syst
Externí odkaz:
https://doaj.org/article/ce526fab2b10415481440f37aab9d0a1
Autor:
Steven T Kosak, David Scalzo, Sam V Alworth, Fusheng Li, Stephanie Palmer, Tariq Enver, James S J Lee, Mark Groudine
Publikováno v:
PLoS Biology, Vol 5, Iss 11, p e309 (2007)
Gene loci are found in nuclear subcompartments that are related to their expression status. For instance, silent genes are often localized to heterochromatin and the nuclear periphery, whereas active genes tend to be found in the nuclear center. Evid
Externí odkaz:
https://doaj.org/article/6fbbb082d8a840d5b2ff70558f20e746
Autor:
Joan C. Ritland Politz, Katherine Chiu, Mark Groudine, Feng Yue, Clifford P. Brangwynne, Xiaotao Wang, Andrew D. Stephens, David Scalzo, Ronald J Biggs, Leah J Tait, Edward J. Banigan, Amy R. Strom, John F. Marko, Agnes Telling, Cameron Herman, Jimena Collado
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Chromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus. Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromati
Autor:
Leah J Tait, Katherine Chiu, John F. Marko, Mark Groudine, Andrew D. Stephens, Edward J. Banigan, Amy R. Strom, Clifford P. Brangwynne, David Scalzo, Feng Yue, Joan C. Ritland Politz, Xiaotao Wang, Jimena Collado, Agnes Telling, Cameron Herman, Ronald J Biggs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e808b8c73a749ef08cf9097acca5c2
https://doi.org/10.7554/elife.63972.sa2
https://doi.org/10.7554/elife.63972.sa2
Publikováno v:
Current Opinion in Genetics & Development. 37:1-8
Two chromatin compartments are present in most mammalian cells; the first contains primarily euchromatic, early replicating chromatin and the second, primarily late-replicating heterochromatin, which is the subject of this review. Heterochromatin is
Autor:
Vivek Nandakumar, Félix Recillas-Targa, David Scalzo, Hector Rincon-Arano, Andrea Casasola, Mark Groudine, Jessica Halow
Publikováno v:
Nucleus
Lamin A is part of a complex structural meshwork located beneath the nuclear envelope and is involved in both structural support and the regulation of gene expression. Lamin A is initially expressed as prelamin A, which contains an extended carboxyl
Publikováno v:
Nucleus
The eukaryotic nucleus is structurally and functionally organized, as reflected in the distribution of its protein and DNA components. The genome itself is segregated into euchromatin and heterochromatin that replicate in a distinct spatio-temporal m
Publikováno v:
Nucleus. 2:249-252
Adaptability and "emergent" properties are the dominant characteristics of complex systems, whether naturally occurring or engineered. Structurally, a complex system might be made up of a large number of simpler components, or it might be formed from
Autor:
Charles Kooperberg, Steven T. Kosak, David Scalzo, Mark Groudine, Michael D. Perlman, Indika Rajapakse
Publikováno v:
Proceedings of the National Academy of Sciences. 106:6679-6684
Although the importance of chromosome organization during mitosis is clear, it remains to be determined whether the nucleus assumes other functionally relevant chromosomal topologies. We have previously shown that homologous chromosomes have a tenden