Zobrazeno 1 - 10
of 17
pro vyhledávání: '"David Scadden"'
Autor:
Eva M Fast, Audrey Sporrij, Margot Manning, Edroaldo Lummertz Rocha, Song Yang, Yi Zhou, Jimin Guo, Ninib Baryawno, Nikolaos Barkas, David Scadden, Fernando Camargo, Leonard I Zon
Publikováno v:
eLife, Vol 10 (2021)
Hematopoietic stem cells (HSCs) must ensure adequate blood cell production following distinct external stressors. A comprehensive understanding of in vivo heterogeneity and specificity of HSC responses to external stimuli is currently lacking. We per
Externí odkaz:
https://doaj.org/article/2fe2e574cbf147d699ad25e6263b78b4
Publikováno v:
Bio-Protocol, Vol 11, Iss 19 (2021)
Once thought to be a mere consequence of the state of a cell, intermediary metabolism is now recognized as a key regulator of mammalian cell fate and function. In addition, cell metabolism is often disturbed in malignancies such as cancer, and target
Externí odkaz:
https://doaj.org/article/1fe4490761ff434eab8c48ed0951d4ee
Autor:
Lijian Shao, Jianhui Chang, Wei Feng, Xiaoyan Wang, Elizabeth A. Williamson, Ying Li, Amir Schajnovitz, David Scadden, Luke J. Mortensen, Charles P. Lin, Linheng Li, Ariel Paulson, James Downing, Daohong Zhou, Robert A. Hromas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Hematopoietic stem cells (HSCs) migrate from the fetal liver to the bone marrow (BM) during embryogenesis. Here the authors show that the WAVE2 complex scaffold Hem1 is required for engraftment of HSCs in BM, not through its canonical role regulating
Externí odkaz:
https://doaj.org/article/4dc6c1370dff42ada8f865c1c679a6ac
Autor:
Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani, Leonard Guarente
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 3, Pp 430-440 (2013)
Abstract Mesenchymal stem cells (MSCs) are multi‐potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a function in MSCs by cr
Externí odkaz:
https://doaj.org/article/d6fce7dc458e4c2090ba9165d4886d3d
Autor:
Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani, Leonard Guarente
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 3, Pp 482-482 (2013)
Externí odkaz:
https://doaj.org/article/3a011196ed9441b88abf021164dde0b1
Abstract 2456: Transcriptional signatures of stem cell phenotypes in normal and clonal hematopoiesis
Publikováno v:
Cancer Research. 83:2456-2456
Clonal hematopoiesis (CH) is an age-related clonal expansion of hematopoietic stem cells (HSCs). Factors that shape the progression of CH are only beginning to be characterized. HSCs are a heterogeneous population of cells with distinct clonal output
Autor:
Taghreed Hirz, Shenglin Mei, Hirak Sarkar, Youmna Kfoury, Shulin Wu, Bronte Verhoeven, Alexander Subtelny, Dimitar Zlatev, Matthew Wszolek, Keyan Salari, Evan Murray, Fei Chen, Evan Macosko, Chin-Lee Wu, David Scadden, Douglas Dahl, Ninib Baryawno, Philip Saylor, Peter Kharchenko, David Sykes
SummaryThe treatment of primary prostate cancer delicately balances an active surveillance approach for low-risk disease with multimodal treatment including surgery, radiation therapy, and hormonal therapy for high-risk disease. Recurrence and develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d477c7edfdcd15d9f7b24e12f8d9997
https://doi.org/10.1101/2022.03.18.484781
https://doi.org/10.1101/2022.03.18.484781
Publikováno v:
Day 4 Fri, September 10, 2021.
Modern drill bits designs have become more efficient using static modelling, and in more advanced cases, time-based dynamic modelling. These methods have created improved cutting structures that fail rock more effectively, however, at-bit vibrations
Autor:
Eva M Fast, Audrey Sporrij, Margot Manning, Edroaldo Lummertz Rocha, Song Yang, Yi Zhou, Jimin Guo, Ninib Baryawno, Nikolaos Barkas, David Scadden, Fernando Camargo, Leonard I Zon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5db4da690db1c40aebc3ecd7966796c0
https://doi.org/10.7554/elife.66512.sa2
https://doi.org/10.7554/elife.66512.sa2
Publikováno v:
Experimental Hematology. 100:S41