Zobrazeno 1 - 10
of 34
pro vyhledávání: '"David San León"'
Publikováno v:
Plant Signaling & Behavior, Vol 18, Iss 1 (2023)
Methyltransferase (MTase) enzymes catalyze the addition of a methyl group to a variety of biological substrates. MTase-like (METTL) proteins are Class I MTases whose enzymatic activities contribute to the epigenetic and epitranscriptomic regulation o
Externí odkaz:
https://doaj.org/article/98ccf1f896454df8b0acd1574ffefc64
Autor:
Anita van den Heuvel, Saskia Lassche, Karlien Mul, Anna Greco, David San León Granado, Arend Heerschap, Benno Küsters, Stephen J. Tapscott, Nicol C. Voermans, Baziel G. M. van Engelen, Silvère M. van der Maarel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract With several therapeutic strategies for facioscapulohumeral muscular dystrophy (FSHD) entering clinical testing, outcome measures are becoming increasingly important. Considering the spatiotemporal nature of FSHD disease activity, clinical t
Externí odkaz:
https://doaj.org/article/57f2734de5df4b63b76dcb2ef71b6ffa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7091 (2023)
Bacillus subtilis is an effective workhorse for the production of many industrial products. The high interest aroused by B. subtilis has guided a large metabolic modeling effort of this species. Genome-scale metabolic models (GEMs) are powerful tools
Externí odkaz:
https://doaj.org/article/87103d3957e24c97aec3b66fac35aa37
Autor:
Nahikari López-López, David San León, Sonia de Castro, Roberto Díez-Martínez, Manuel Iglesias-Bexiga, María José Camarasa, Margarita Menéndez, Juan Nogales, Junkal Garmendia
Publikováno v:
mSystems, Vol 7, Iss 2 (2022)
ABSTRACT Expediting drug discovery to fight antibacterial resistance requires holistic approaches at system levels. In this study, we focused on the human-adapted pathogen Haemophilus influenzae, and by constructing a high-quality genome-scale metabo
Externí odkaz:
https://doaj.org/article/2eb5f41787924291a0d68fb9e2bd261e
Autor:
Tobias Goris, Álvaro Pérez‐Valero, Igor Martínez, Dong Yi, Luis Fernández‐Calleja, David San León, Uwe T. Bornscheuer, Patricia Magadán‐Corpas, Felipe Lombó, Juan Nogales
Publikováno v:
Microbial Biotechnology, Vol 14, Iss 1, Pp 94-110 (2021)
Summary Coronavirus‐related disease 2019 (COVID‐19) became a pandemic in February 2020, and worldwide researchers try to tackle the disease with approved drugs of all kinds, or to develop novel compounds inhibiting viral spreading. Flavonoids, al
Externí odkaz:
https://doaj.org/article/d833417f64214a7f9e445fde806dc003
Autor:
Alfonso González de Prádena, Adrián Sánchez Jimenez, David San León, Peter Simmonds, Juan Antonio García, Adrián A. Valli
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The presence of CpG and UpA dinucleotides is restricted in the genomes of animal RNA viruses to avoid specific host defenses. We wondered whether a similar phenomenon exists in nonanimal RNA viruses. Here, we show that these two dinucleotide
Externí odkaz:
https://doaj.org/article/599322be8cb14b98a7484a8880f4344f
Autor:
Alberto Carbonell, Varvara I. Maliogka, José de Jesús Pérez, Beatriz Salvador, David San León, Juan Antonio García, Carmen Simón-Mateo
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 26, Iss 10, Pp 1211-1224 (2013)
Plum pox virus (PPV)-D and PPV-R are two isolates from strain D of PPV that differ in host specificity. Previous analyses of chimeras originating from PPV-R and PPV-D suggested that the N terminus of the coat protein (CP) includes host-specific patho
Externí odkaz:
https://doaj.org/article/6c118d17992b4bc2866c3f3c5b3c0b05
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132281 (2015)
The use of syn-tasiRNAs has been proposed as an RNA interference technique alternative to those previously described: hairpin based, virus induced gene silencing or artificial miRNAs. In this study we engineered the TAS1c locus to impair Plum pox vir
Externí odkaz:
https://doaj.org/article/82a4f6b4c8114131bdf814ed3ffe80fc
Autor:
Bernardo Rodamilans, David San León, Louisa Mühlberger, Thierry Candresse, Michael Neumüller, Juan Carlos Oliveros, Juan Antonio García
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100477 (2014)
Plum pox virus (PPV) infects Prunus trees around the globe, posing serious fruit production problems and causing severe economic losses. One variety of Prunus domestica, named 'Jojo', develops a hypersensitive response to viral infection. Here we com
Externí odkaz:
https://doaj.org/article/2f988ab88b4545538fdfecbd557788a8
Autor:
Bernardo Rodamilans, Juan C. Oliveros, David San León, Pedro J. Martínez-García, Pedro Martínez-Gómez, Juan A. García, Manuel Rubio
Publikováno v:
Phytopathology®. 112:2012-2021
Plum pox virus (PPV) causes sharka disease in Prunus trees. Peach (P. persica) trees are severely affected by PPV, and no definitive source of genetic resistance has been identified. However, previous results showed that PPV-resistant ‘Garrigues’