Výsledky vyhledávání - "David S.W. Boam"

Site-specific regulation of tissue dendritic cell function by granulocyte-macrophage colony-stimulating-factor

Autor: Tanakorn Proungvitaya, Peter Wood, Joanne Lees, David S.W. Boam

Publikováno v: Immunology. 113:482-490

Tissue dendritic cells (DC) are usually associated with phagocytic function but poor T-cell immunostimulatory capacity. Following activation, dendritic cells are stimulated to leave tissue sites and migrate to lymphoid tissue, acquiring immunostimula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd0f3b90a870e38781979866183684f
https://doi.org/10.1111/j.1365-2567.2004.01981.x

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DNA-binding activity of the transcription factor upstream stimulatory factor 1 (USF-1) is regulated by cyclin-dependent phosphorylation

Autor: Edwin Cheung, Petra S.M. Mayr, Federico Coda-Zabetta, Phillip G. Woodman, David S.W. Boam

Publikováno v: Biochemical Journal. 344:145-152

The ubiquitous transcription factor upstream stimulatory factor (USF) 1 is a member of the bzHLH (leucine zipper-basic-helix-loop-helix) family, which is structurally related to the Myc family of proteins. It plays a role in the regulation of many ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8fc3d7861b4747f0087e5c3ac2ba5fc
https://doi.org/10.1042/bj3440145

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A TATA-less Promoter Containing Binding Sites for Ubiquitous Transcription Factors Mediates Cell Type-specific Regulation of the Gene for Transcription Enhancer Factor-1 (TEF-1)

Autor: David S.W. Boam, Irwin Davidson, Pierre Chambon

Publikováno v: Journal of Biological Chemistry. 270:19487-19494

TEF-1 is a tissue-specific human transcription factor which binds to and activates transcription from the SV40 early promoter and the HPV-16 E6/E7 promoter and may be involved in regulation of muscle-specific and placenta-specific gene expression. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a70645cc7d06df7e6b5d2770e77ab3
https://doi.org/10.1074/jbc.270.33.19487

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Differential gene expression between Zucker Fatty rats and Zucker Diabetic Fatty rats: a potential role for the immediate-early gene Egr-1 in regulation of beta cell proliferation

Autor: Phil Chapman, Ian D. Waddell, Kay E Garnett, David S.W. Boam, Julie A Chambers

Publikováno v: Journal of molecular endocrinology. 35(1)

The β-cell failure that characterises type 2 diabetes is likely to involve altered expression of many genes. We aimed to identify global changes in gene expression underlying β-cell dysfunction in pre-diabetic Zucker Diabetic Fatty rat islets, foll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931648079d7a2126a822a8961060655e
https://pubmed.ncbi.nlm.nih.gov/16087718

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DNA binding by the ETS-domain transcription factor PEA3 is regulated by intramolecular and intermolecular protein.protein interactions

Autor: David S.W. Boam, Andrew D. Sharrocks, Nicola Willingham, Amanda Greenall, Ed Cheung

Publikováno v: The Journal of biological chemistry. 276(19)

The control of DNA binding by eukaryotic transcription factors represents an important regulatory mechanism. Many transcription factors are controlled by cis-acting autoinhibitory modules that are thought to act by blocking promiscuous DNA binding in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0825bba4ff4f9c76c07e3c8067e9215b
https://pubmed.ncbi.nlm.nih.gov/11278941

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Distinct effects of ATP on transcription complex formation and initiation in a yeast in vitro transcription system

Autor: Federico Coda-Zabetta, David S.W. Boam

Publikováno v: Biochimica et biophysica acta. 1306(2-3)

The stages and kinetics of transcription complex formation in a Saccharomyces cerevisiae in vitro transcription system were analysed using the anionic detergent sarkosyl. In contrast to findings from other systems, we were not able to distinguish bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a145301a4002a1b802ea4ab98a6850ae
https://pubmed.ncbi.nlm.nih.gov/8634337

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Insulin upstream factor 1 and a novel ubiquitous factor bind to the human islet amyloid polypeptide/amylin gene promoter

Autor: Nicola Gore, Deborah Bretherton-Watt, David S.W. Boam

Publikováno v: The Biochemical journal. 313

The islet amyloid polypeptide (IAPP) gene is expressed primarily in the islet β-cell and the peptide is co-secreted with insulin. To investigate mechanisms important in its regulation, we have used the electrophoretic mobility-shift assay and methyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a848d4254782e80e2dbc1e490b1047
https://pubmed.ncbi.nlm.nih.gov/8573083

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