Zobrazeno 1 - 10
of 285
pro vyhledávání: '"David S. Ziegler"'
Autor:
Eden G. Robertson, Kate Hetherington, Rebecca Daly, Mark W. Donoghoe, Nicholas Handelsman, David S. Ziegler, Claire E. Wakefield
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Background Patient‐reported outcomes measures (PROMs) are increasingly being collected within cancer clinical trials, yet limited literature on the feasibility and acceptability of doing so. Methods We collected parent‐proxy and adolesce
Externí odkaz:
https://doaj.org/article/c410b79109df4d86876e4705fb6a2e02
Autor:
Cornelis M. van Tilburg, Lindsay B. Kilburn, Sébastien Perreault, Rene Schmidt, Amedeo A. Azizi, Ofelia Cruz-Martínez, Michal Zápotocký, Katrin Scheinemann, Antoinette Y. N. Schouten-van Meeteren, Astrid Sehested, Enrico Opocher, Pablo Hernáiz Driever, Shivaram Avula, David S. Ziegler, David Capper, Arend Koch, Felix Sahm, Jiaheng Qiu, Li-Pen Tsao, Samuel C. Blackman, Peter Manley, Till Milde, Ruth Witt, David T. W. Jones, Darren Hargrave, Olaf Witt
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Pediatric low-grade glioma (pLGG) is essentially a single pathway disease, with most tumors driven by genomic alterations affecting the mitogen-activated protein kinase/ERK (MAPK) pathway, predominantly KIAA1549::BRAF fusions and
Externí odkaz:
https://doaj.org/article/6042d3662e6a4c2d9fc8d41531bad22c
Autor:
Carolyn G. Mazariego, Skye McKay, Elijah Tyedmers, Lauren Kelada, Brittany C. McGill, Rebecca Daly, Claire E. Wakefield, David S. Ziegler, Natalie Taylor
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
ObjectivesPaediatric oncologists often encounter challenges when seeking compassionate access to off-label therapies for their patients. This study employed implementation science and co-design techniques to develop the ProCure medicines database, wi
Externí odkaz:
https://doaj.org/article/8abf31985bfa47b2a579f84840cc599c
Autor:
Chelsea Mayoh, Andrew J. Gifford, Rachael Terry, Loretta M. S. Lau, Marie Wong, Padmashree Rao, Tyler Shai-Hee, Federica Saletta, Dong-Anh Khuong-Quang, Vicky Qin, Marion K. Mateos, Deborah Meyran, Katherine E. Miller, Aysen Yuksel, Emily V. A. Mould, Rachel Bowen-James, Dinisha Govender, Akanksha Senapati, Nataliya Zhukova, Natacha Omer, Hetal Dholaria, Frank Alvaro, Heather Tapp, Yonatan Diamond, Luciano Dalla Pozza, Andrew S. Moore, Wayne Nicholls, Nicholas G. Gottardo, Geoffrey McCowage, Jordan R. Hansford, Seong-Lin Khaw, Paul J. Wood, Daniel Catchpoole, Catherine E. Cottrell, Elaine R. Mardis, Glenn M. Marshall, Vanessa Tyrrell, Michelle Haber, David S. Ziegler, Orazio Vittorio, Joseph A. Trapani, Mark J. Cowley, Paul J. Neeson, Paul G. Ekert
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a
Externí odkaz:
https://doaj.org/article/fbd7979e6f4b4aebb70a711623639d1f
Autor:
Pamela Ajuyah, Chelsea Mayoh, Loretta M. S. Lau, Paulette Barahona, Marie Wong, Hazel Chambers, Fatima Valdes-Mora, Akanksha Senapati, Andrew J. Gifford, Colleen D’Arcy, Jordan R. Hansford, Neevika Manoharan, Wayne Nicholls, Molly M. Williams, Paul J. Wood, Mark J. Cowley, Vanessa Tyrrell, Michelle Haber, Paul G. Ekert, David S. Ziegler, Dong-Anh Khuong-Quang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Diffuse midline gliomas (DMG) harbouring H3K27M mutation are paediatric tumours with a dismal outcome. Recently, a new subtype of midline gliomas has been described with similar features to DMG, including loss of H3K27 trimethylation, but la
Externí odkaz:
https://doaj.org/article/8e8fabf3268f4381b287194aa795890c
Autor:
Sarah M. Trinder, Campbell McKay, Phoebe Power, Monique Topp, Bosco Chan, Santosh Valvi, Geoffrey McCowage, Dinisha Govender, Maria Kirby, David S. Ziegler, Neevika Manoharan, Tim Hassall, Stewart Kellie, John Heath, Frank Alvaro, Paul Wood, Stephen Laughton, Karen Tsui, Andrew Dodgshun, David D. Eisenstat, Raelene Endersby, Stephen J. Luen, Eng-Siew Koh, Hao-Wen Sim, Benjamin Kong, Nicholas G. Gottardo, James R. Whittle, Dong-Anh Khuong-Quang, Jordan R. Hansford
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The mitogen-activated protein kinase (MAPK) pathway signaling pathway is one of the most commonly mutated pathways in human cancers. In particular, BRAF alterations result in constitutive activation of the rapidly accelerating fibrosarcoma–extracel
Externí odkaz:
https://doaj.org/article/b70dc0b5bc9c4f5f8e61a5acca858e20
Autor:
Jacqueline P. Whitehouse, Hilary Hii, Chelsea Mayoh, Marie Wong, Pamela Ajuyah, Paulette Barahona, Louise Cui, Hetal Dholaria, Christine L. White, Molly K. Buntine, Jacob Byrne, Keteryne Rodrigues da Silva, Meegan Howlett, Emily J. Girard, Maria Tsoli, David S. Ziegler, Jason M. Dyke, Sharon Lee, Paul G. Ekert, Mark J. Cowley, Nicholas G. Gottardo, Raelene Endersby
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionEpendymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14
Externí odkaz:
https://doaj.org/article/009c2573d20c46b8a58d763a746781a4
Autor:
Jena V. Lilly, Jo Lynne Rokita, Jennifer L. Mason, Tatiana Patton, Stephanie Stefankiewiz, David Higgins, Gerri Trooskin, Carina A. Larouci, Kamnaa Arya, Elizabeth Appert, Allison P. Heath, Yuankun Zhu, Miguel A. Brown, Bo Zhang, Bailey K. Farrow, Shannon Robins, Allison M. Morgan, Thinh Q. Nguyen, Elizabeth Frenkel, Kaitlin Lehmann, Emily Drake, Catherine Sullivan, Alexa Plisiewicz, Noel Coleman, Luke Patterson, Mateusz Koptyra, Zeinab Helili, Nicholas Van Kuren, Nathan Young, Meen Chul Kim, Christopher Friedman, Alex Lubneuski, Christopher Blackden, Marti Williams, Valerie Baubet, Lamiya Tauhid, Jamie Galanaugh, Katie Boucher, Heba Ijaz, Kristina A. Cole, Namrata Choudhari, Mariarita Santi, Robert W. Moulder, Jonathan Waller, Whitney Rife, Sharon J. Diskin, Marion Mateos, Donald W. Parsons, Ian F. Pollack, Stewart Goldman, Sarah Leary, Chiara Caporalini, Anna Maria Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Ron Firestein, Jason Cain, Joanna J. Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey P. Greenfield, Rintaro Hashizume, Amy Smith, Shida Zhu, James M. Johnston, Jason R. Fangusaro, Matthew Miller, Matthew D. Wood, Sharon Gardner, Claire L. Carter, Laura M. Prolo, Jared Pisapia, Katherine Pehlivan, Andrea Franson, Toba Niazi, Josh Rubin, Mohamed Abdelbaki, David S. Ziegler, Holly B. Lindsay, Ana Guerreiro Stucklin, Nicolas Gerber, Olena M. Vaske, Carolyn Quinsey, Brian R. Rood, Javad Nazarian, Eric Raabe, Eric M. Jackson, Stacie Stapleton, Robert M. Lober, David E. Kram, Carl Koschmann, Phillip B. Storm, Rishi R. Lulla, Michael Prados, Adam C. Resnick, Angela J. Waanders
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 35, Iss , Pp 100846- (2023)
Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term
Externí odkaz:
https://doaj.org/article/ccba034296a747dd98510c07ca0814c3
Autor:
Rebecca Daly, Kate Hetherington, Emily Hazell, Bethany R. Wadling, Vanessa Tyrrell, Katherine M. Tucker, Glenn M. Marshall, David S. Ziegler, Loretta M. S. Lau, Toby N. Trahair, Tracey A. O’Brien, Kiri Collins, Andrew J. Gifford, Michelle Haber, Mark Pinese, David Malkin, Mark J. Cowley, Jonathan Karpelowsky, Donna Drew, Chris Jacobs, Claire E. Wakefield
Publikováno v:
Journal of Personalized Medicine, Vol 13, Iss 7, p 1033 (2023)
Precision medicine programs aim to utilize novel technologies to identify personalized treatments for children with cancer. Delivering these programs requires interdisciplinary efforts, yet the many groups involved are understudied. This study explor
Externí odkaz:
https://doaj.org/article/ebb8f8472a954e148f3f353dc5bb6b5d
Autor:
Neevika Manoharan, Pamela Ajuyah, Akanksha Senapati, Marie Wong, Anna Mullins, Michael Rodriguez, Helen Doyle, Geoff McCowage, Loretta M. S. Lau, Paul G. Ekert, David S. Ziegler
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-11 (2021)
Abstract Diffuse leptomeningeal glioneuronal tumours (DLGNT) represent rare enigmatic CNS tumours of childhood. Most patients with this disease share common radiological and histopathological features but the clinical course of this disease is variab
Externí odkaz:
https://doaj.org/article/2fffe9ecbf6a45a3a78cee93cf94d83d