Zobrazeno 1 - 10
of 439
pro vyhledávání: '"David S. Williams"'
Autor:
Anne Huber, Amr H. Allam, Christine Dijkstra, Stefan Thiem, Jennifer Huynh, Ashleigh R. Poh, Joshua Konecnik, Saumya P. Jacob, Rita Busuttil, Yang Liao, David Chisanga, Wei Shi, Mariah G. Alorro, Stephen Forrow, Daniele V.F. Tauriello, Eduard Batlle, Alex Boussioutas, David S. Williams, Michael Buchert, Matthias Ernst, Moritz F. Eissmann
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114616- (2024)
Summary: Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations account for frequent aberrations in human gastric cancers, neither the sequence nor the individual contributions of these mutations have been clarified. Here,
Externí odkaz:
https://doaj.org/article/bcbb4c19d532433d8228119f5febdeda
Autor:
Laura J. Jenkins, Ian Y. Luk, Fiona Chionh, Tao Tan, Kristen Needham, Jamieson Ayton, Camilla M. Reehorst, Natalia Vukelic, Oliver M. Sieber, Dmitri Mouradov, Peter Gibbs, David S. Williams, Niall C. Tebbutt, Jayesh Desai, Frédéric Hollande, Amardeep S. Dhillon, Erinna F. Lee, Delphine Merino, W. Douglas Fairlie, John M. Mariadason
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-9 (2024)
Abstract Metastatic BRAF V600E colorectal cancer (CRC) carries an extremely poor prognosis and is in urgent need of effective new treatments. While the BRAFV600E inhibitor encorafenib in combination with the EGFR inhibitor cetuximab (Enc+Cet) was rec
Externí odkaz:
https://doaj.org/article/6e4f88d9b616433e88bdbae69ee002cc
Autor:
Nilofar Faruqui, David S. Williams, Andrea Briones, Ibolya E. Kepiro, Jascindra Ravi, Tristan O.C. Kwan, Andrew Mearns-Spragg, Maxim G. Ryadnov
Publikováno v:
Materials Today Bio, Vol 22, Iss , Pp 100786- (2023)
Extracellular matrix type 0 is reported. The matrix is developed from a jellyfish collagen predating mammalian forms by over 0.5 billion years. With its ancient lineage, compositional simplicity, and resemblance to multiple collagen types, the matrix
Externí odkaz:
https://doaj.org/article/4736cf5b67294ba8b08fa6c1e8999223
Autor:
Fiona Chionh, Val Gebski, Sheren J. Al-Obaidi, Jennifer K. Mooi, Maressa A. Bruhn, Chee K. Lee, Anderly C. Chüeh, David S. Williams, Andrew J. Weickhardt, Kate Wilson, Andrew M. Scott, John Simes, Jennifer E. Hardingham, Timothy J. Price, John M. Mariadason, Niall C. Tebbutt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The phase III MAX clinical trial randomised patients with metastatic colorectal cancer (mCRC) to receive first-line capecitabine chemotherapy alone or in combination with the anti-VEGF-A antibody bevacizumab (± mitomycin C). We utilised thi
Externí odkaz:
https://doaj.org/article/87f820d614bf43b899d6fc21783461db
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Dexamethasone (Dex) is a highly insoluble front-line drug used in cancer therapy. Data from clinical trials indicates that the pharmacokinetics of Dex vary considerably between patients and prolonging drug exposure rather than increasing abs
Externí odkaz:
https://doaj.org/article/7b565fee84e34ae2a46e1d888530d47a
Autor:
Shoupeng Cao, Jingxin Shao, Hanglong Wu, Shidong Song, Maria Teresa De Martino, Imke A. B. Pijpers, Heiner Friedrich, Loai K. E. A. Abdelmohsen, David S. Williams, Jan C. M. van Hest
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Induced motion has emerged as a method to increase the efficacy of delivery and therapeutic outcomes using nanomaterials. Here, the authors report on a Janus gold shell polymersome with aggregation-induced emission molecules for phototactic and photo
Externí odkaz:
https://doaj.org/article/08061092da6c49d19976a8c7e6dbf6d7
Autor:
Cynthia Tang, Jimin Han, Sonal Dalvi, Kannan Manian, Lauren Winschel, Stefanie Volland, Celia A. Soto, Chad A. Galloway, Whitney Spencer, Michael Roll, Caroline Milliner, Vera L. Bonilha, Tyler B. Johnson, Lisa Latchney, Jill M. Weimer, Erika F. Augustine, Jonathan W. Mink, Vamsi K. Gullapalli, Mina Chung, David S. Williams, Ruchira Singh
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
CLN3 disease is characterised by childhood-onset vision loss and premature death. Using patient-derived retinal cells, the authors show that CLN3 is required for retinal pigment epithelium (RPE) cell structure, microvilli and phagocytosis of photorec
Externí odkaz:
https://doaj.org/article/3a26677720f143228deb8043e7d31748
Autor:
Duarte Nuno Carvalho, Flávia C. M. Lobo, Luísa C. Rodrigues, Emanuel M. Fernandes, David S. Williams, Andrew Mearns-Spragg, Carmen G. Sotelo, Ricardo I. Perez-Martín, Rui L. Reis, Michael Gelinsky, Tiago H. Silva
Publikováno v:
Gels, Vol 9, Iss 3, p 247 (2023)
The self-repair capacity of human tissue is limited, motivating the arising of tissue engineering (TE) in building temporary scaffolds that envisage the regeneration of human tissues, including articular cartilage. However, despite the large number o
Externí odkaz:
https://doaj.org/article/8c1d6e306df544b1bd1c844165d91cce
Autor:
Roni A. Hazim, David S. Williams
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The retinal pigment epithelium (RPE) is a uniquely polarized epithelium that lies adjacent to the photoreceptor cells in the retina, and is essential for photoreceptor function and viability. Two major motile organelles present in the RPE are the mel
Externí odkaz:
https://doaj.org/article/9b15c59afbef4e98afa3ec119ad0a762
Autor:
Nan W. Hultgren, Jennifer S. Fang, Mary E. Ziegler, Ricardo N. Ramirez, Duc T. T. Phan, Michaela M. S. Hatch, Katrina M. Welch-Reardon, Antonio E. Paniagua, Lin S. Kim, Nathan N. Shon, David S. Williams, Ali Mortazavi, Christopher C. W. Hughes
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through
Externí odkaz:
https://doaj.org/article/8e37d57515834f55b45498858d31ca32