Zobrazeno 1 - 10
of 260
pro vyhledávání: '"David S. Watt"'
Autor:
Lichao Guo, Baochen Zhang, Wen Zhang, Yanqi Xie, Xi Chen, Xueke Sun, David S. Watt, Chunming Liu, H. Peter Spielmann, Xifu Liu
Publikováno v:
Cancers, Vol 16, Iss 7, p 1399 (2024)
Cancer cells undergo a significant level of “metabolic reprogramming” or “remodeling” to ensure an adequate supply of ATP and “building blocks” for cell survival and to facilitate accelerated proliferation. Cancer cells preferentially use
Externí odkaz:
https://doaj.org/article/51bc802742f641589dc53e26e8989c39
Autor:
Roberto Gedaly, Virgilius Cornea, Lilia Turcios, Jacob S. Edmisson, Dwight D. Harris, David S. Watt, Fanny Chapelin, Aman Khurana, Xiaonan Mei, Chunming Liu, Isaac Taylor, Juan Gonzalez-Valdivieso, Hunter Mitchel, Alexis Ruffing, Asir Chishti, Gabriel Orozco, Joseph Zwischenberger, B. Mark Evers, Francesc Marti
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Regulatory T cells (Tregs) are essential to maintain self-tolerance and immune homeostasis but, as components of the tumor microenvironment (TME), are also a major barrier to effective cancer immunosurveillance and immunotherapy. FH535 and i
Externí odkaz:
https://doaj.org/article/95985ca8558f441fbeb54809d7eb80cf
Autor:
Xi Chen, Xiaocheng Lv, Lijie Gao, Jiawei Liu, Wei Wang, Lichao Guo, Mykhaylo S. Frasinyuk, Wen Zhang, David S. Watt, Chunming Liu, Xifu Liu
Publikováno v:
Cells, Vol 12, Iss 7, p 1066 (2023)
The deregulation in the Wnt/β-catenin signaling pathway is associated with many human cancers, particularly colorectal cancer (CRC) and, therefore, represents a promising target for drug development. We have screened over 300 semisynthetic and natur
Externí odkaz:
https://doaj.org/article/7726626d031d44d991c2266d92689ad7
Autor:
Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101795- (2020)
Summary: Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC). As part of a program to develop epigenetic regulators for cancer therapy
Externí odkaz:
https://doaj.org/article/c10f7711030744a6997f7f1ff875703c
Autor:
Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 508-519 (2017)
Summary: The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secreti
Externí odkaz:
https://doaj.org/article/3ebeceb7b56a457eb08f0dec28efe808
Autor:
Yang Yang-Hartwich, Chunming Liu, David S. Watt, Liliia M. Kril, Wen Zhang, Jaeyeon Kim, Dongin Kim, Madeline J. Morrison, Kevin Yang, Kay Y. Chong, Zhiping Ge, Tobias M.P. Hartwich, Wonmin Park, Ziyan Jiang, Fangfang Bi
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies and requires new therapeutic strategies to improve clinical outcomes. EOC metastasizes in the abdominal cavity through dissemination in the peritoneal fluid a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dafc189f786fbc2e4e4ef1e64ef919e
https://doi.org/10.1158/1535-7163.c.6543261.v1
https://doi.org/10.1158/1535-7163.c.6543261.v1
Autor:
Chunming Liu, David S. Watt, B. Mark Evers, Xiaoqi Liu, Tianyan Gao, Chi Wang, Daheng He, Eun Y. Lee, Xifu Liu, Xi Chen, Vitaliy M. Sviripa, Kristin L. Begley, Liliia M. Kril, Lichao Guo, Wen Zhang, Yanqi Xie
Developing effective treatments for colorectal cancers through combinations of small-molecule approaches and immunotherapies present intriguing possibilities for managing these otherwise intractable cancers. During a broad-based, screening effort aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694b4dea3916cecf923dc87e75a2681d
https://doi.org/10.1158/1535-7163.c.6542721.v1
https://doi.org/10.1158/1535-7163.c.6542721.v1
Autor:
Chunming Liu, David S. Watt, Xifu Liu, H. Peter Spielmann, B. Mark Evers, Yekaterina Y. Zaytseva, Baochen Zhang, Mengqiang Lian, Emma E. Olmstead, Xi Chen, Yanqi Xie, Wen Zhang, Lichao Guo
Cancer cells undergo significant “metabolic remodeling” to provide sufficient ATP to maintain cell survival and to promote rapid growth. In colorectal cancer cells, ATP is produced by mitochondrial oxidative phosphorylation and by substantially e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240d496fab60ecb6d50a453d03c4b691
https://doi.org/10.1158/1535-7163.c.6543421.v1
https://doi.org/10.1158/1535-7163.c.6543421.v1
Autor:
Chunming Liu, David S. Watt, Xifu Liu, H. Peter Spielmann, B. Mark Evers, Yekaterina Y. Zaytseva, Baochen Zhang, Mengqiang Lian, Emma E. Olmstead, Xi Chen, Yanqi Xie, Wen Zhang, Lichao Guo
Supplementary Data from Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38e014fccbba7b1efb1509bb69efb83
https://doi.org/10.1158/1535-7163.22522540.v1
https://doi.org/10.1158/1535-7163.22522540.v1
Autor:
Yang Yang-Hartwich, Chunming Liu, David S. Watt, Liliia M. Kril, Wen Zhang, Jaeyeon Kim, Dongin Kim, Madeline J. Morrison, Kevin Yang, Kay Y. Chong, Zhiping Ge, Tobias M.P. Hartwich, Wonmin Park, Ziyan Jiang, Fangfang Bi
Supplementary Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198be69b782e83189a9f07fb9fe882e5
https://doi.org/10.1158/1535-7163.22522035.v1
https://doi.org/10.1158/1535-7163.22522035.v1