Zobrazeno 1 - 10
of 25
pro vyhledávání: '"David S. Wagner"'
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1180 (2022)
(1) Imaging of pharmaceutical compounds in tissue is an increasingly important subsection of Mass Spectrometry Imaging (MSI). Identifying proper target engagement requires MS platforms with high sensitivity and spatial resolution. Three prominent cat
Externí odkaz:
https://doaj.org/article/79ce490f354548acbe8d3e4dea6c435d
Autor:
Graeme C. Young, Douglas K. Spracklin, Alexander D. James, Mette G. Hvenegaard, Graeme Scarfe, David S. Wagner, Katrin Georgi, Hanno Schieferstein, Inga Bjornsdottir, Bianca van Groen, Andrea A. Romeo, Kenneth C. Cassidy, Georges Da‐violante, Bojan Bister, Stefan Blech, Ramaswamy Lyer, Simone I. Schulz, Filip Cuyckens, Patricia Moliner
Publikováno v:
Clinical pharmacology and therapeutics.
The human absorption, distribution, metabolism, and excretion (hADME) study is the cornerstone of the clinical pharmacology package for small molecule drugs, providing comprehensive information on the rates and routes of disposition and elimination o
Autor:
Phuong Huynh, David S. Wagner, Lee Moss, William Spreen, Yu Lou, Gary D Bowers, Susan L. Ford, Amanda G. Culp, Rennan Pan, Melinda J. Reese, Glenn Tabolt, David A. Margolis, Stephen C. Piscitelli, Elizabeth Gould
Publikováno v:
Xenobiotica. 46:147-162
1. Cabotegravir [(3S,11aR)-N-[(2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide] is an HIV-1 integrase inhibitor under development as a tablet for both oral lead-in
Autor:
Carie L. Kimbrough, Roger H. Brown, Joanna C. Barton, Stephen Castellino, David Bailey, David S. Wagner, Richard A. Peterson, Catherine A. Faber, Lisa D. Gates, Holly L. Jordan, Mario Sola, Mark Bickett, Zhaohai Zhu, Chandikumar S. Elangbam, Laura Hagerty
Publikováno v:
Journal of Applied Toxicology. 34:1122-1129
Cardiolipin (CL) is crucial for mitochondrial energy metabolism and structural integrity. Alterations in CL quantity or CL species have been associated with mitochondrial dysfunction in several pathological conditions and diseases, including mitochon
Publikováno v:
Xenobiotica. 45:60-70
1. Plasma clearance of dolutegravir, an unboosted HIV-1 integrase inhibitor, was low in rat and monkey (0.23 and 2.12 mL/min/kg, respectively) as was the volume of distribution (0.1 and 0.28 L/kg, respectively) with terminal elimination half-life app
Autor:
Paul Savina, Shuguang Chen, Ivy Song, Amanda G. Culp, Lee Moss, Stephen Castellino, David S. Wagner, Stephen C. Piscitelli, Igor Goljer, Yu Lou, Sherene S. Min, Julie Borland
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3536-3546
The pharmacokinetics, metabolism, and excretion of dolutegravir, an unboosted, once-daily human immunodeficiency virus type 1 integrase inhibitor, were studied in healthy male subjects following single oral administration of [ 14 C]dolutegravir at a
Publikováno v:
Bioanalysis. 5:463-479
Effective characterization of drug metabolites in complex biological matrices is facilitated by mass spectrometers with high resolving power, mass accuracy and sensitivity. This review begins with an overview of high-resolution MS terminology and the
Autor:
James Myer, J. Sigafoos, David S. Wagner, Mark de Serres, M. Reid Groseclose, Joseph W. Polli, Stephen Castellino, Elizabeth Romach, Brad Hamilton
Publikováno v:
Chemical Research in Toxicology. 26:241-251
The CNS disposition and metabolism of Fosdevirine (FDV), an HIV non-nucleoside reverse transcriptase inhibitor, was investigated in four patients who unexpectedly experienced seizures after at least 4 weeks of treatment in a Phase IIb, HIV-1 treatmen
Autor:
Wenli Tao, J. Sigafoos, Robert L. Dobbins, Anita Kapur, Stephen Castellino, David S. Wagner, Joan E. Humphreys, Joseph W. Polli, Melinda J. Reese, Elizabeth K. Hussey, Gary D Bowers, Amanda G. Culp, Robin L. O'Connor Semmes
Publikováno v:
Drug Metabolism and Disposition. 40:2090-2101
Remogliflozin etabonate is the ester prodrug of remogliflozin, a selective sodium-dependent glucose cotransporter-2 inhibitor. This work investigated the absorption, metabolism, and excretion of [(14)C]remogliflozin etabonate in humans, as well as th
Publikováno v:
Bioanalysis. 3:2427-2441
Our understanding of drug tissue distribution impacts a number of areas in drug development, including: pharmacology, pharmacokinetics, safety, drug–drug interactions, transport and metabolism. Despite their extensive use, autoradiography and tissu