Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David S. Uygun"'
Autor:
Koustav Roy, Xuzhao Zhou, Rintaro Otani, Ping-Chuan Yuan, Shuji Ioka, Kaspar E. Vogt, Tamae Kondo, Nouran H. T. Farag, Haruto Ijiri, Zhaofa Wu, Youhei Chitose, Mao Amezawa, David S. Uygun, Yoan Cherasse, Hiroshi Nagase, Yulong Li, Masashi Yanagisawa, Manabu Abe, Radhika Basheer, Yi-Qun Wang, Tsuyoshi Saitoh, Michael Lazarus
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Optochemistry, an emerging pharmacologic approach in which light is used to selectively activate or deactivate molecules, has the potential to alleviate symptoms, cure diseases, and improve quality of life while preventing uncontrolled drug
Externí odkaz:
https://doaj.org/article/4431e78e019340f7971afef4a23b66d7
Autor:
David S. Uygun, Radhika Basheer
Publikováno v:
Brain Research Bulletin, Vol 188, Iss , Pp 223-232 (2022)
Sleep is vital and the deepest stages of sleep occur within Non-rapid-eye-movement sleep (NREM), defined by high electroencephalographic power in the delta (~0.5–4 Hz) wave frequency range. Delta waves are thought to facilitate a myriad of physical
Externí odkaz:
https://doaj.org/article/72b1815b268743a8b651e425de902ad4
Autor:
David S. Uygun, Chun Yang, Elena R. Tilli, Fumi Katsuki, Erik L. Hodges, James T. McKenna, James M. McNally, Ritchie E. Brown, Radhika Basheer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Uygun et al. show that deletion of GABAA receptors from the thalamic reticular nucleus using CRISPR gene editing in mice boosts the delta waves, indicating a role for GABAA receptors on thalamic reticular nucleus neurons in NREM sleep delta oscillati
Externí odkaz:
https://doaj.org/article/f103563cadb64548a47d87698d2e0166
Autor:
Robin K. Yuan, Matthew R. Lopez, Manuel-Miguel Ramos-Alvarez, Marc E. Normandin, Arthur S. Thomas, David S. Uygun, Vanessa R. Cerda, Amandine E. Grenier, Matthew T. Wood, Celia M. Gagliardi, Herminio Guajardo, Isabel A. Muzzio
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109234- (2021)
Summary: Poor sleep quality is associated with age-related cognitive decline, and whether reversal of these alterations is possible is unknown. In this study, we report how sleep deprivation (SD) affects hippocampal representations, sleep patterns, a
Externí odkaz:
https://doaj.org/article/363db46d507146ac81515b7f0f0e1959
Autor:
David S, Uygun, Chun, Yang, Elena R, Tilli, Fumi, Katsuki, Erik L, Hodges, James T, McKenna, James M, McNally, Ritchie E, Brown, Radhika, Basheer
Publikováno v:
Nature communications. 13(1)
Identification of mechanisms which increase deep sleep could lead to novel treatments which promote the restorative effects of sleep. Here, we show that knockdown of the α3 GABA
Autor:
Ritchie E. Brown, Fumi Katsuki, David S. Uygun, Chun Yang, Radhika Basheer, James T. McKenna, James M. McNally, Elena R. Tilli
Identification of mechanisms which increase deep sleep could lead to novel treatments which promote the restorative effects of sleep. Here, knockdown of the α3 GABAA-receptor subunit from parvalbumin neurons in the thalamic reticular nucleus using C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4484f8311b144394355c8aab530fbb9d
https://doi.org/10.1101/2020.12.15.422912
https://doi.org/10.1101/2020.12.15.422912
Autor:
Megan Fitzgerald, lingling Yang, Karena Yan, Kazuo Imaizumi, David S. Uygun, Soon-Wook Choi, David Baez-Nieto, Jen Q. Pan, Zhanyan Fu, Xiaohong Mao, Mario A. Arias-Garcia, Shaun Purcell, Thomas B. Nicholson, Andrew S. Allen, Guoping Feng, Jen M. Hope, James M. McNally, Qiangge Zhang, Ritchie E. Brown, Ayan Ghoshal, Robert E. Strecker, Violeta G. Lopez-Huerta
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
CACNA1I, a schizophrenia risk gene, encodes a subtype of voltage-gated T-type calcium channel CaV3.3. We previously reported that a patient-derived missense de novo mutation (R1346H) of CACNA1I impaired CaV3.3 channel function. Here, we generated CaV
Autor:
M. E. N. Normandin, Matthew T. Wood, David S. Uygun, Arthur Thomas, Herminio Guajardo, Celia M. Gagliardi, Robin K. Yuan, Isabel A. Muzzio, Vanessa R. Cerda, Manuel-Miguel Ramos-Alavarez, Amandine E. Grenier, Matthew R. Lopez
SummaryAge-related changes in sleep patterns have been linked to cognitive decline. Specifically, increasing age is associated with increasing fragmentation of sleep and wake cycles. However, it remains unknown if improvements in sleep architecture c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3fc173900f1bb19a061cfe60d1c7d7
https://doi.org/10.1101/2020.01.20.912915
https://doi.org/10.1101/2020.01.20.912915
Autor:
Isabel A. Muzzio, Celia M. Gagliardi, Amandine E. Grenier, Arthur Thomas, Matthew T. Wood, Herminio Guajardo, David S. Uygun, Robin K. Yuan, Matthew R. Lopez, Vanessa R. Cerda, M. E. N. Normandin, Manuel-Miguel Ramos-Alvarez
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 11, Pp 109234-(2021)
Cell Reports, Vol 35, Iss 11, Pp 109234-(2021)
SUMMARY Poor sleep quality is associated with age-related cognitive decline, and whether reversal of these alterations is possible is unknown. In this study, we report how sleep deprivation (SD) affects hippocampal representations, sleep patterns, an
Autor:
Fumi Katsuki, Joshua Cordeira, Robert W. McCarley, James M. McNally, Radhika Basheer, Ritchie E. Brown, Mackenzie C. Gamble, Robert E. Strecker, David S. Uygun, Charu Shukla, Janneke C. Zant, Stephen Thankachan, Karl Deisseroth, Felipe L. Schiffino, James T. McKenna
The ability to rapidly arouse from sleep is important for survival. However, increased arousals in patients with sleep apnea and other disorders prevent restful sleep and contribute to cognitive, metabolic, and physiologic dysfunction [1, 2]. Little
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d389d692dbdc923d337861e7db5c4c96