Zobrazeno 1 - 10
of 27
pro vyhledávání: '"David S. Umbaugh"'
Autor:
Giselle Sanchez-Guerrero, David S. Umbaugh, Abhay A. Ramachandran, Antonio Artigues, Hartmut Jaeschke, Anup Ramachandran
Publikováno v:
Livers, Vol 4, Iss 1, Pp 15-30 (2023)
The adenosine A2B receptor (A2BAR) is a member of a family of G-protein coupled receptors (GPCRs), which has a low affinity for adenosine and is now implicated in several pathophysiological conditions. We have demonstrated the beneficial effects of A
Externí odkaz:
https://doaj.org/article/ceb664350c874129ba3fca2decf832c9
Publikováno v:
Livers, Vol 2, Iss 4, Pp 425-435 (2022)
Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in response to an overdose. Understanding the mechanisms of APAP-induced cell death is critical for identifying new therapeutic targets. In this respect
Externí odkaz:
https://doaj.org/article/7c1cae44c9c84f8198c922efeb97c038
Autor:
Dakota R. Robarts, Steven R. McGreal, David S. Umbaugh, Wendena S. Parkes, Manasi Kotulkar, Sarah Abernathy, Norman Lee, Hartmut Jaeschke, Sumedha Gunewardena, Stephen A. Whelan, John A. Hanover, Natasha E. Zachara, Chad Slawson, Udayan Apte
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1510-1529 (2022)
Background & Aims: The liver has a unique capacity to regenerate after injury in a highly orchestrated and regulated manner. Here, we report that O-GlcNAcylation, an intracellular post-translational modification regulated by 2 enzymes, O-GlcNAc trans
Externí odkaz:
https://doaj.org/article/ea3c4596c6654707b658a0f0be83e403
Autor:
Hartmut Jaeschke, Olamide B. Adelusi, Jephte Y. Akakpo, Nga T. Nguyen, Giselle Sanchez-Guerrero, David S. Umbaugh, Wen-Xing Ding, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Externí odkaz:
https://doaj.org/article/bd69267488f147738d37afb49958d353
Publikováno v:
Livers, Vol 1, Iss 3, Pp 102-115 (2021)
Mitochondria have been studied for decades from the standpoint of metabolism and ATP generation. However, in recent years mitochondrial dynamics and its influence on bioenergetics and cellular homeostasis is also being appreciated. Mitochondria under
Externí odkaz:
https://doaj.org/article/d3645c0a37d44468ab54a8a24bfe5a94
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Peripheral neuropathy (PN), a debilitating complication of diabetes, is associated with obesity and the metabolic syndrome in nondiabetic individuals. Evidence indicates that a high fat diet can induce signs of diabetic peripheral PN in mice but the
Externí odkaz:
https://doaj.org/article/7ff8bdb47e7a4897bcb5ab3c2136a4a0
Autor:
Nga T. Nguyen, David S. Umbaugh, Sawyer Smith, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Anup Ramachandran, Hartmut Jaeschke
Publikováno v:
Archives of Toxicology. 97:1397-1412
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::422eae9dc9a3c2ad9d43474cd0387f63
https://doi.org/10.1007/s00204-023-03478-4
https://doi.org/10.1007/s00204-023-03478-4
Autor:
David S. Umbaugh, Rupal P. Soder, Nga T. Nguyen, Olamide Adelusi, Dakota R. Robarts, Ben Woolbright, Luqi Duan, Sunil Abhyankar, Buddhadeb Dawn, Udayan Apte, Hartmut Jaeschke, Anup Ramachandran
Publikováno v:
Archives of Toxicology. 96:3315-3329
The persistence of hepatotoxicity induced by N-acetyl-para-aminophenol (Acetaminophen or Paracetamol, abbreviated as APAP) as the most common cause of acute liver failure in the United States, despite the availability of N-acetylcysteine, illustrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a24a68acde419f137446e1bddb7f8e1
https://doi.org/10.1007/s00204-022-03372-5
https://doi.org/10.1007/s00204-022-03372-5
Autor:
Nga T Nguyen, David S Umbaugh, Eileen L Huang, Olamide B Adelusi, Giselle Sanchez Guerrero, Anup Ramachandran, Hartmut Jaeschke
Publikováno v:
Toxicol Sci
Acetaminophen (APAP) overdose is the main cause of acute liver failure in Western countries. The mechanism of APAP hepatotoxicity is associated with centrilobular necrosis which initiates infiltration of neutrophils, monocytes, and other leukocytes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52742d4d3f6f9e4971eac5d30062edb6
https://doi.org/10.1093/toxsci/kfac057
https://doi.org/10.1093/toxsci/kfac057
Publikováno v:
Livers. 2(4)
Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in response to an overdose. Understanding the mechanisms of APAP-induced cell death is critical for identifying new therapeutic targets. In this respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4266abddb9db463ddb4247ad9f348d11
https://pubmed.ncbi.nlm.nih.gov/36588962
https://pubmed.ncbi.nlm.nih.gov/36588962