Zobrazeno 1 - 10
of 66
pro vyhledávání: '"David S. Taylor"'
Autor:
Morad Ansari, Jacqueline Rainger, Isabel M Hanson, Kathleen A Williamson, Freddie Sharkey, Louise Harewood, Angela Sandilands, Jill Clayton-Smith, Helene Dollfus, Pierre Bitoun, Francoise Meire, Judy Fantes, Brunella Franco, Birgit Lorenz, David S Taylor, Fiona Stewart, Colin E Willoughby, Meriel McEntagart, Peng Tee Khaw, Carol Clericuzio, Lionel Van Maldergem, Denise Williams, Ruth Newbury-Ecob, Elias I Traboulsi, Eduardo D Silva, Mukhlis M Madlom, David R Goudie, Brian W Fleck, Dagmar Wieczorek, Juergen Kohlhase, Alice D McTrusty, Carol Gardiner, Christopher Yale, Anthony T Moore, Isabelle Russell-Eggitt, Lily Islam, Melissa Lees, Philip L Beales, Stephen J Tuft, Juan B Solano, Miranda Splitt, Jens Michael Hertz, Trine E Prescott, Deborah J Shears, Ken K Nischal, Martine Doco-Fenzy, Fabienne Prieur, I Karen Temple, Katherine L Lachlan, Giuseppe Damante, Danny A Morrison, Veronica van Heyningen, David R FitzPatrick
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153757 (2016)
We report molecular genetic analysis of 42 affected individuals referred with a diagnosis of aniridia who previously screened as negative for intragenic PAX6 mutations. Of these 42, the diagnoses were 31 individuals with aniridia and 11 individuals r
Externí odkaz:
https://doaj.org/article/b653c7a9f55349049c0c5eae18e1736f
Autor:
Ji Jiang, Tammy C. Wang, Alice Ye A. Chen, Xiaohong Yin, Jennifer X. Qiao, Ming Chang, Muthoni G. Kamau, Julia Li, David S. Taylor, Leonard P. Adam, Lalgudi S. Harikrishnan, Xue-Qing Chen, Heather Finlay, R. Michael Lawrence, Richard Rampulla, Paul Levesque, Christine Huang, Paul G. Sleph, Carrie Xu, Ruth R. Wexler, Mark E. Salvati
Publikováno v:
ACS Med Chem Lett
[Image: see text] Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the N-terminus position in the DPPE series resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0dc9b771eed0176133985ac09f68ab
https://doi.org/10.1021/acsmedchemlett.9b00086
https://doi.org/10.1021/acsmedchemlett.9b00086
Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors
Autor:
Xiaohong Ying, Joelle M. Onorato, Heather Finlay, Nathalie Toussaint, Tammy C. Wang, Yi-Xin Li, David S. Taylor, Ruth R. Wexler, Alice Y.A. Chen, Carol Hui Hu, Jennifer X. Qiao, Lauren Haque, Christine Huang, Lynn M. Abell, Leonard P. Adam, David A. Gordon, Hong Shen, Michael Galella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3721-3725
Endothelial lipase (EL) inhibitors have been shown to elevate HDL-C levels in pre-clinical murine models and have potential benefit in prevention and treatment of cardiovascular diseases. Modification of the 1-ethyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f34b9fdb0d49079297505501a5f661
https://doi.org/10.1016/j.bmcl.2018.10.022
https://doi.org/10.1016/j.bmcl.2018.10.022
Autor:
Doree F. Sitkoff, Alice Y. Chen, Hongwei Zhang, Anne Rose, Xue-Qing Chen, Cailan Wang, Leonard P. Adam, Mimi L. Quan, Nathan L. Cheadle, Zilun Hu, Lisa Zhang, David S. Taylor, Ruth R. Wexler, Songmei Xu, John S. Sack, Joseph E. Myers, Victor R. Guarino, James Hennan, Peter W. Glunz, Chunhong Yan, Julia Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(21)
Structure-activity relationship optimization on a series of phenylpyrazole amides led to the identification of a dual ROCK1 and ROCK2 inhibitor (25) which demonstrated good potency, kinome selectivity and favorable pharmacokinetic profiles. Compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995bf0c5f6f2e8dbdc6c12fb55d1327a
https://pubmed.ncbi.nlm.nih.gov/32798651
https://pubmed.ncbi.nlm.nih.gov/32798651
Autor:
David S. Taylor, Lei Zhao, Leonard P. Adam, David A. Gordon, Michael Basso, Alice Ye Chen, Eddie C.-K. Liu, Ji Jiang, Christian Caporuscio, Zulan Pi, James A. Johnson, Soong-Hoon Kim, Heather Finlay, John Lloyd, Joelle M. Onorato, Gregory A. Locke, George O. Tora, Ruth R. Wexler, Todd Kirshgessner, Lynn M. Abell, Xiaohong Yin, Hao Lu, Richard Yang, Sarah C. Traeger, Monique Phillips, Kamelia Behnia, Carol S. Ryan
Publikováno v:
Journal of medicinal chemistry. 63(4)
Endothelial lipase (EL) hydrolyzes phospholipids in high-density lipoprotein (HDL) resulting in reduction in plasma HDL levels. Studies with murine transgenic, KO, or loss-of-function variants strongly suggest that inhibition of EL will lead to susta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac63d0f0187919bbe4a9cac88560ae41
https://pubmed.ncbi.nlm.nih.gov/31990537
https://pubmed.ncbi.nlm.nih.gov/31990537
Autor:
Ji Jiang, James Neels, David A. Gordon, Ruth R. Wexler, Alice Ye A. Chen, Michael Basso, Jon J. Hangeland, Leonard P. Adam, Heather Finlay, Paul G. Sleph, Lynn M. Abell, Richard Yang, Thomas Harrity, R. Michael Lawrence, David S. Taylor, Lauren Haque, Christine Huang, Xiaohong Yin, Todd J. Friends, Joelle M. Onorato
Publikováno v:
ACS Medicinal Chemistry Letters. 9:673-678
[Image: see text] Screening of a small set of nonselective lipase inhibitors against endothelial lipase (EL) identified a potent and reversible inhibitor, N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide (5;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f785fa1a2ceebdbf57f8010e5dea4a83
https://doi.org/10.1021/acsmedchemlett.8b00138
https://doi.org/10.1021/acsmedchemlett.8b00138
Autor:
Leonard P. Adam, Wei Meng, Ruth R. Wexler, Lisa M. Kopcho, Heather Finlay, Richard Yang, Xiaohong Yin, Kamelia Behnia, David S. Taylor, Gregory A. Locke, Lei Zhao
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(20)
A series of benzothiazoles with a cyano group was synthesized and evaluated as endothelial lipase (EL) inhibitors for the potential treatment of cardiovascular diseases. Efforts to reduce molecular weight and polarity in the series led to improved ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d066a528718e06e53e431b6fbfee1443
https://pubmed.ncbi.nlm.nih.gov/31519373
https://pubmed.ncbi.nlm.nih.gov/31519373
Autor:
Lynn M. Abell, Brandon Parkhurst, Lei Zhao, Richard Yang, David A. Gordon, Jennifer X. Qiao, Soong-Hoon Kim, Xue-Qing Chen, Joelle M. Onorato, David S. Taylor, Hao Lu, Michael Basso, Alice Ye Chen, Kamelia Behnia, Heather Finlay, Xiaohong Yin, Leonard P. Adam, Ji Jiang, Gregory A. Locke, George O. Tora, Zulan Pi, Monique Phillips, Christian Caporuscio, Ruth R. Wexler, Eddie C.-K. Liu, James A. Johnson
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(15)
A low level of high density lipoprotein (HDL) is an independent risk factor for cardiovascular disease. HDL reduces inflammation and plays a central role in reverse cholesterol transport, where cholesterol is removed from peripheral tissues and ather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bb80bb08fc94d5bc6f7fade64d10c3
https://pubmed.ncbi.nlm.nih.gov/31353296
https://pubmed.ncbi.nlm.nih.gov/31353296
Autor:
Leonard P. Adam, James A. Johnson, Paul G. Sleph, Ruth R. Wexler, Heather Finlay, Mark E. Salvati, Lalgudi S. Harikrishnan, David S. Taylor, Alice Ye A. Chen, Xiaohong Yin, Richard Yang, Muthoni G. Kamau, Jennifer X. Qiao, Tammy C. Wang, Ji Jiang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3278-3281
Hydroxyl 1,2-diphenylethanamine analogs were identified as potent inhibitors of cholesterol ester transfer protein (CETP), a therapeutic target to raise HDL cholesterol. In an effort to improve the pharmaceutical properties in the previously disclose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa943329052d80158e1a4d52c0bbdae7
https://doi.org/10.1016/j.bmcl.2016.05.058
https://doi.org/10.1016/j.bmcl.2016.05.058
Autor:
Xue-Qing Chen, Xiaohong Yin, Gregory A. Locke, Hao Lu, Lei Zhao, Kamelia Behnia, David A. Gordon, Michael Galella, James A. Johnson, Christian Caporuscio, Heather Finlay, Anne Rose, Alice Y. Chen, Michael Basso, Ruth R. Wexler, Richard Yang, George O. Tora, Lynn M. Abell, Joelle M. Onorato, Monique Phillips, David S. Taylor, Zulan Pi, Leonard P. Adam
[Image: see text] Endothelial lipase (EL) selectively metabolizes high density lipoprotein (HDL) particles. Inhibition of EL has been shown to increase HDL concentration in preclinical animal models and was targeted as a potential treatment of athero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4149ab696aa75e4cc6167e8691b9fa
https://europepmc.org/articles/PMC6295870/
https://europepmc.org/articles/PMC6295870/
