Zobrazeno 1 - 10
of 45
pro vyhledávání: '"David S. Talaga"'
Publikováno v:
The Journal of Physical Chemistry Letters. 3:3081-3087
We suggest a coarse-grained model for DPD simulations of polypeptides in solutions. The model mimics hydrogen bonding that stabilizes α-helical and β-structures using dissociable Morse bonds between quasiparticles representing the peptide groups am
Publikováno v:
Journal of Molecular Biology. 395:134-154
We combine atomic-force-microscopy particle-size-distribution measurements with earlier measurements on 1-anilino-8-naphthalene sulfonate, thioflavin T, and dynamic light scattering to develop a quantitative kinetic model for the aggregation of β-la
Autor:
Jiali Li, David S. Talaga
Publikováno v:
Journal of the American Chemical Society. 131:9287-9297
We use single silicon nitride nanopores to study folded, partially folded, and unfolded single proteins by measuring their excluded volumes. The DNA-calibrated translocation signals of beta-lactoglobulin and histidine-containing phosphocarrier protei
Autor:
David S. Talaga
Publikováno v:
The Journal of Physical Chemistry A. 113:5251-5263
Time correlated single photon counting allows luminescence lifetime information to be determined on a single molecule level. This paper develops a formalism to allow information theory analysis of the ability of luminescence lifetime measurements to
Publikováno v:
The Journal of Physical Chemistry B. 112:11422-11434
We use time-dependent fluorescence Stokes shift (TDFSS) information to study the fluctuation rates of the lipocalin, beta-lactoglobulin A in the vicinity of an encapsulated coumarin 153 molecule. The system has three unique dielectric environments in
Publikováno v:
Analytical Chemistry. 80:1689-1695
Microfluidic devices face presently a tremendous interest, especially for the development of labs-on-a-chip systems. One of the primary challenges for such applications is the ability to perform local chemical detection and analysis from various spec
Autor:
David S. Talaga
Publikováno v:
Current Opinion in Colloid & Interface Science. 12:285-296
This article examines the current status of Markov processes in single molecule fluorescence. For molecular dynamics to be described by a Markov process, the Markov process must include all states involved in the dynamics and the first-passage time (
Publikováno v:
The Journal of Physical Chemistry B. 110:16366-16376
The interpretation of single-molecule measurements is greatly complicated by the presence of multiple fluorescent labels. However, many molecular systems of interest consist of multiple interacting components. We investigate this issue using multiply
Autor:
David S. Talaga, Jeffrey I. Zink
Publikováno v:
The Journal of Physical Chemistry A. 105:10511-10519
Intervalence electron transfer spectra in mixed-valence molecules are frequently modeled by an interacting pair of adiabatic potential energy surfaces. The presence or absence of a double minimum in the lower surface is correlated with trapped or del
Autor:
William F. DeGrado, Robin M. Hochstrasser, Yiwei Jia, Wai Leung Lau, David S. Talaga, Helen S. M. Lu
Publikováno v:
Chemical Physics. 247:69-83
We have prepared a bichromophoric crosslinked variant of GCN4-P1 for single-molecule fluorescence energy transfer experiments (GCN4-Pf). The folding and unfolding fluctuations of single GCN4-Pf molecules are measured in a two-channel confocal microsc