Zobrazeno 1 - 10
of 131
pro vyhledávání: '"David S. Segal"'
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Bingeing is one pattern of high dose methamphetamine (METH) abuse which involves continuous drug taking over several days and can result in psychotic behaviors for which the brain pathology remains poorly-defined. A corresponding animal model of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8221c2d861d0643ac0bde1ca1fe1e353
https://doi.org/10.1038/npp.2009.73
https://doi.org/10.1038/npp.2009.73
Publikováno v:
Synapse. 61:515-522
Rats exposed to methamphetamine (METH) in an acute high dose “binge” pattern have been reported to exhibit a persistent deficit in a novel object recognition (NOR) task, which may suggest a potential risk for human METH abusers. However, most hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a2dd79c56918c0b3b43f9ea2531e70
https://doi.org/10.1002/syn.20397
https://doi.org/10.1002/syn.20397
Publikováno v:
Neuropsychopharmacology. 31:2359-2367
Methamphetamine (METH) administration mimics many of the symptoms of mania and can produce psychosis after chronic use. Both rodents and man display interindividual variation in response to METH. The molecular mechanisms underlying these differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b04713c3d45b1e81fe99b332d96660
https://doi.org/10.1038/sj.npp.1301162
https://doi.org/10.1038/sj.npp.1301162
Autor:
Meghan L. O’Neil, Goran Lacan, William P. Melega, Arthur K. Cho, David S. Segal, Ronald Kuczenski
Publikováno v:
Synapse. 60:465-473
A major feature of human methamphetamine (METH) abuse is the gradual dose escalation that precedes high-dose exposure. The period of escalating doses (EDs) is likely associated with development of tolerance to aspects of METH's pharmacologic and toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830081871a12f2852826452bf0559f0f
https://doi.org/10.1002/syn.20320
https://doi.org/10.1002/syn.20320
Autor:
David S. Segal, Ronald Kuczenski
Publikováno v:
Biological Psychiatry. 57:1391-1396
Most evidence supports the continued use of stimulants as the best available pharmacotherapy for the treatment of children with attention-deficit/hyperactivity disorder (ADHD), but little is known about possible enduring behavioral and neuroadaptatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257f0a1f89ac1c04e233b591138a31bd
https://doi.org/10.1016/j.biopsych.2004.12.036
https://doi.org/10.1016/j.biopsych.2004.12.036
Publikováno v:
Neuropsychopharmacology. 28:1730-1740
The neurotoxic effects of methamphetamine (METH) have been characterized primarily from the study of high-dose binge regimens in rodents. However, this drug administration paradigm does not include a potentially important feature of stimulant abuse i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab93fb96c350fcd1682b015ba5c1148
https://doi.org/10.1038/sj.npp.1300247
https://doi.org/10.1038/sj.npp.1300247
Autor:
Ronald Kuczenski, David S. Segal
Publikováno v:
Journal of Neurochemistry. 68:2032-2037
Methylphenidate promotes a dose-dependent behavioral profile that is very comparable to that of amphetamine. Amphetamine increases extracellular norepinephrine and serotonin, in addition to its effects on dopamine, and these latter effects may play a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e9a0254229531d3d4922a8c8a26f31
https://doi.org/10.1046/j.1471-4159.1997.68052032.x
https://doi.org/10.1046/j.1471-4159.1997.68052032.x
Autor:
Ronald Kuczenski, David S. Segal
Publikováno v:
The Journal of Neuroscience. 22:7264-7271
Methylphenidate (MP) (ritalin) is widely used in the treatment of children and adolescents with attention deficit hyperactivity disorder, but little is known about therapeutic mechanisms or about possible consequences of long-term exposure. To more c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9990ae5c428f5fcc185f02ce7a8545
https://doi.org/10.1523/jneurosci.22-16-07264.2002
https://doi.org/10.1523/jneurosci.22-16-07264.2002
Autor:
Ronald Kuczenski, David S. Segal
Publikováno v:
Brain Research. 923:32-38
Exposure of experimental animals to an escalating dose, multiple binge pattern of methamphetamine administration results in the progressive emergence of a unique behavioral profile, which includes a significant decrease in the duration of the stereot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6505d9f1224fe643763c8e8a8525142
https://doi.org/10.1016/s0006-8993(01)03193-6
https://doi.org/10.1016/s0006-8993(01)03193-6
Autor:
Ronald Kuczenski, Thomas B. Barrett, John R. Kelsoe, Alexander B. Niculescu, David S. Segal, Richard L. Hauger
Publikováno v:
Physiological Genomics. 4:83-91
We have used methamphetamine treatment of rats as an animal model for psychotic mania. Specific brain regions were analyzed comprehensively for changes in gene expression using oligonucleotide GeneChip microarrays. The data was cross-matched against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41058e007b3a8adb4aa196a4eb57f4d
https://doi.org/10.1152/physiolgenomics.2000.4.1.83
https://doi.org/10.1152/physiolgenomics.2000.4.1.83