Zobrazeno 1 - 10
of 22
pro vyhledávání: '"David S. Pitcher"'
Autor:
Elisa Ferraro, Lidia Pozhidaeva, David S. Pitcher, Catherine Mansfield, Jia Han Benjamin Koh, Catherine Williamson, Oleg Aslanidi, Julia Gorelik, Fu Siong Ng
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Acute myocardial ischaemia and reperfusion (I–R) are major causes of ventricular arrhythmias in patients with a history of coronary artery disease. Ursodeoxycholic acid (UDCA) has previously been shown to be antiarrhythmic in fetal hearts.
Externí odkaz:
https://doaj.org/article/78d9b779398c45159eddde8c4749c272
Autor:
Richard J. Jabbour, Thomas J. Owen, Pragati Pandey, Marina Reinsch, Brian Wang, Oisín King, Liam Steven Couch, Dafni Pantou, David S. Pitcher, Rasheda A. Chowdhury, Fotios G. Pitoulis, Balvinder S. Handa, Worrapong Kit-Anan, Filippo Perbellini, Rachel C. Myles, Daniel J. Stuckey, Michael Dunne, Mayooran Shanmuganathan, Nicholas S. Peters, Fu Siong Ng, Florian Weinberger, Cesare M. Terracciano, Godfrey L. Smith, Thomas Eschenhagen, Sian E. Harding
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Engineered heart tissue (EHT) strategies, by combining cells within a hydrogel matrix, may be a novel therapy for heart failure. EHTs restore cardiac function in rodent injury models, but more data are needed in clinically relevant settings. Accordin
Externí odkaz:
https://doaj.org/article/5f7e39207cc8495596ab20ad1eee6e60
Autor:
David S. Pitcher, Kate de Mattos-Shipley, Konstantinos Tzortzis, Holger W. Auner, Anastasios Karadimitris, Maurits F. Kleijnen
Publikováno v:
EBioMedicine, Vol 2, Iss 7, Pp 642-648 (2015)
The proteasome inhibitor Bortezomib is used to treat multiple myeloma (MM). Bortezomib inhibits protein degradation by inactivating proteasomes' active-sites. MM cells are exquisitely sensitive to Bortezomib – exhibiting a low-nanomolar IC50 – su
Externí odkaz:
https://doaj.org/article/dac0543ad72f41d1be390db0bd98e837
Autor:
Min-young Kim, James Nesbitt, Simos Koutsoftidis, Joseph Brook, David S Pitcher, Chris D Cantwell, Balvinder Handa, Catherine Jenkins, Charles Houston, Stephen Rothery, Anand Jothidasan, Justin Perkins, Poppy Bristow, Nick W F Linton, Emm Drakakis, Nicholas S Peters, Rasheda A Chowdhury, Prapa Kanagaratnam, Fu Siong Ng
Publikováno v:
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.
AimsThe response to high frequency stimulation (HFS) is used to locate putative sites of ganglionated plexuses (GPs), which are implicated in triggering atrial fibrillation (AF). To identify topological and immunohistochemical characteristics of pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af8b62eef5d75aa761fae88d25d21ef
https://pubmed.ncbi.nlm.nih.gov/36260428
https://pubmed.ncbi.nlm.nih.gov/36260428
Autor:
Xinyang Li, Anastasia Shchendrygina, Catherine Mansfield, Fu Siong Ng, Nicholas S. Peters, Nicoleta Baxan, Caroline H. Roney, David S. Pitcher, Balvinder S. Handa, Richard J. Jabbour, Rasheda A. Chowdhury
Publikováno v:
Cardiovasc Res
Aims Conflicting data exist supporting differing mechanisms for sustaining ventricular fibrillation (VF), ranging from disorganised multiple-wavelet activation to organised rotational activities (RAs). Abnormal gap junction (GJ) coupling and fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59822e0177343fca5098091cb7cc4ac6
https://doi.org/10.1093/cvr/cvaa141
https://doi.org/10.1093/cvr/cvaa141
Autor:
Rasha Al-Lamee, Matthew J. Shun-Shin, Harry W. Barnett, Jamil Mayet, David S. Pitcher, Darrel P. Francis, Vitaliy Androshchuk, Luke Howard, Nicholas S. Peters, Ricardo Petraco, Sukhjinder Nijjer, David M. Miller, Gulam S. Haji, Henry Seligman, Sameer Zaman, Oscar Ces, Sayan Sen, Nick Linton, Freya Hepworth Lloyd
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257133 (2021)
PLoS ONE
PLoS ONE
During viral pandemics, filtering facepiece (FFP) masks together with eye protection form the essential components of personal protective equipment (PPE) for healthcare workers. There remain concerns regarding insufficient global supply and imperfect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604b7c9158b0adfce695fa2b7cb65aaf
http://hdl.handle.net/10044/1/93803
http://hdl.handle.net/10044/1/93803
Autor:
Rasheda A. Chowdhury, Marina Reinsch, Godfrey L. Smith, Dafni Pantou, Mayooran Shanmuganathan, Florian Weinberger, Fu Siong Ng, Thomas Eschenhagen, Liam Couch, Thomas J. Owen, Oisín King, Cesare M. Terracciano, David S. Pitcher, Daniel J. Stuckey, Nicholas S. Peters, Balvinder S. Handa, Richard J. Jabbour, Brian Wang, Pragati Pandey, Michael Dunne, Rachel C. Myles, Worrapong Kit-Anan, Filippo Perbellini, Fotios G. Pitoulis, Sian E. Harding
Publikováno v:
JCI Insight
Engineered heart tissue (EHT) strategies, by combining cells within a hydrogel matrix, may be a novel therapy for heart failure. EHTs restore cardiac function in rodent injury models, but more data are needed in clinically relevant settings. Accordin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f4fe1a459529be1768d0d3158bd657
http://hdl.handle.net/10044/1/90648
http://hdl.handle.net/10044/1/90648
Autor:
Nicholas S. Peters, Oscar Ces, Harry W. Barnett, Ricardo Petraco, Sukhjinder Nijjer, Sameer Zaman, Matthew J. Shun-Shin, Henry Seligman, Sayan Sen, Darrel P. Francis, Gulam S. Haji, Vitaliy Androschuk, Rasha Al-Lamee, Freya Hepworth Lloyd, Nick Linton, Jamil Mayet, Luke Howard, David S. Pitcher, David M. Miller
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0249201 (2021)
PLoS ONE, Vol 16, Iss 4, p e0249201 (2021)
Introduction During viral pandemics, filtering facepiece (FFP) masks together with eye protection form the essential components of personal protective equipment (PPE) for healthcare workers. There remain concerns regarding insufficient global supply
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a274ab1124bb51231587062b1fae447
http://europepmc.org/articles/PMC8021169
http://europepmc.org/articles/PMC8021169
Autor:
Julia Gorelik, Catherine Williamson, Jia Han Benjamin Koh, Catherine Mansfield, David S. Pitcher, Lidia Pozhidaeva, Elisa Ferraro, Oleg Aslanidi, Fu Siong Ng
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Ferraro, E, Pozhidaeva, L, Pitcher, D S, Mansfield, C, Koh, J H B, Williamson, C, Aslanidi, O, Gorelik, J & Ng, F S 2020, ' Prolonged ursodeoxycholic acid administration reduces acute ischaemia-induced arrhythmias in adult rat hearts ', Scientific Reports, vol. 10, no. 1, 15284 . https://doi.org/10.1038/s41598-020-72016-4
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Ferraro, E, Pozhidaeva, L, Pitcher, D S, Mansfield, C, Koh, J H B, Williamson, C, Aslanidi, O, Gorelik, J & Ng, F S 2020, ' Prolonged ursodeoxycholic acid administration reduces acute ischaemia-induced arrhythmias in adult rat hearts ', Scientific Reports, vol. 10, no. 1, 15284 . https://doi.org/10.1038/s41598-020-72016-4
Acute myocardial ischaemia and reperfusion (I–R) are major causes of ventricular arrhythmias in patients with a history of coronary artery disease. Ursodeoxycholic acid (UDCA) has previously been shown to be antiarrhythmic in fetal hearts. This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a020d99364a5d5d5f71ad186e68a0e53
http://europepmc.org/articles/PMC7499428
http://europepmc.org/articles/PMC7499428
Autor:
Min-Young Kim, Charles Houston, Nicholas S. Peters, Fu Siong Ng, Joseph Brook, Suofeiya Ma, Konstantinos N. Tzortzis, Richard J. Jabbour, Simos Koutsoftidis, Chris D. Cantwell, Annam Sufi, David S. Pitcher, Balvinder S. Handa, Ji-Jian Chow, Xinyang Li, Rasheda A. Chowdhury, Danya Agha-Jaffar, Catherine Jenkins, Anil A. Bharath, Anand Jothidasan, Poppy Bristow, Sian E. Harding, Justin Perkins
We describe a human and large animal Langendorff experimental apparatus for live electrophysiological studies and measure the electrophysiological changes due to gap junction uncoupling in human and porcine hearts. The resultant ex vivo intact human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245a5b7591dfb2b35f5ccbb562c03d07
http://hdl.handle.net/10044/1/81864
http://hdl.handle.net/10044/1/81864