Zobrazeno 1 - 10
of 138
pro vyhledávání: '"David S. Phelps"'
Autor:
David S. Phelps, Vernon M. Chinchilli, Lili Yang, Debra Shearer, Judith Weisz, Xuesheng Zhang, Joanna Floros
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Using the Toponome Imaging System (TIS), a serial immunostainer, we studied the patterns of expression of multiple markers in alveolar macrophages (AM) from female mice lacking surfactant protein A (SP-A knockouts; KO) after “rescue” wit
Externí odkaz:
https://doaj.org/article/8ac9b45f5778426ca016c14cc88de810
Autor:
David S. Phelps, Vernon M. Chinchilli, Xuesheng Zhang, Debra Shearer, Judith Weisz, Joanna Floros
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundSurfactant protein-A (SP-A) plays a critical role in lung innate immunity by regulating alveolar macrophages (AM), expression of inflammatory mediators, and other host defense proteins. The toponome imaging system (TIS), a serial immunostai
Externí odkaz:
https://doaj.org/article/68134793cb7844ec8a9cc14fc6545e1d
Autor:
David S. Phelps, Vernon M. Chinchilli, Judith Weisz, Debra Shearer, Xuesheng Zhang, Joanna Floros
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Background We used the Toponome Imaging System (TIS) to identify “patterns of marker expression”, referred to here as combinatorial molecular phenotypes (CMPs) in alveolar macrophages (AM) in response to the innate immune molecule, SP-A1
Externí odkaz:
https://doaj.org/article/5fce687e82db4d42a2273d37203fae46
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2022)
Pulmonary surfactant proteins have many roles in surfactant- related functions and innate immunity. One of these proteins is the surfactant protein A (SP-A) that plays a role in both surfactant-related processes and host defense and is the focus in t
Externí odkaz:
https://doaj.org/article/dfa19340ac7f4be4905cc8e4ebc7664a
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The human innate host defense molecules, SP-A1 and SP-A2 variants, differentially affect survival after infection in mice and in lung transplant patients. SP-A interacts with the sentinel innate immune cell in the alveolus, the alveolar macrophage (A
Externí odkaz:
https://doaj.org/article/00891237f61f48a38bd873981a5e9c03
Autor:
David S. Phelps, Vernon M. Chinchilli, Judith Weisz, Lili Yang, Debra Shearer, Xuesheng Zhang, Joanna Floros
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Alveolar macrophages (AMs) are differentially regulated by human surfactant protein-A1 (SP-A1) or SP-A2. However, AMs are very heterogeneous and differences are difficult to characterize in intact cells. Using the Toponome Imaging System (TIS), an im
Externí odkaz:
https://doaj.org/article/0b47d4f51d2944de83b5cf75390c6f2f
Autor:
Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps, Joanna Floros
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, encoding SP-A1 and SP-A2
Externí odkaz:
https://doaj.org/article/a706419cdf7a4e0d9a0d4e3e664fa943
Autor:
George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros
Publikováno v:
Biology of Sex Differences, Vol 8, Iss 1, Pp 1-15 (2017)
Abstract Background Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially regulate the AM miRNome.
Externí odkaz:
https://doaj.org/article/43743536d5db48219524e748ebe2bae6
Autor:
George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Pulmonary surfactant protein A (SP-A) plays an important role in surfactant metabolism and lung innate immunity. In humans there are two proteins, SP-A1 and SP-A2, encoded by SFTPA1 and SFTPA2, respectively, which are produced by the alveolar type II
Externí odkaz:
https://doaj.org/article/baf9ea18eb9b40de9698f3cbd1ab1faf
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Surfactant protein A (SP-A) plays critical roles in host defense, regulation of inflammation and surfactant metabolism in the lung. The human SP-A locus consists of two functional genes, SFTPA1 and SFTPA2 encoding surfactant proteins SP-A1 and SP-A2,
Externí odkaz:
https://doaj.org/article/e9c972fab3be490d8e4864b8ceb3a060