Zobrazeno 1 - 10
of 49
pro vyhledávání: '"David S. Paul"'
Autor:
Caterina Casari, David S. Paul, Sophie Susen, Cécile Lavenu-Bombled, Annie Harroche, Raymond Piatt, Kathryn O. Poe, Robert H. Lee, Marijke Bryckaert, Olivier D. Christophe, Peter J. Lenting, Cécile V. Denis, Wolfgang Bergmeier
Publikováno v:
Blood Advances, Vol 2, Iss 12, Pp 1417-1428 (2018)
Abstract: von Willebrand disease (VWD) type 2B is characterized by gain-of-function mutations in von Willebrand factor (VWF), enhancing its binding affinity for the platelet receptor glycoprotein (GP)Ibα. VWD type 2B patients display a bleeding tend
Externí odkaz:
https://doaj.org/article/1507902593a948d4b4b113e3cb58c34b
Autor:
Teresa Sevivas, José María Bastida, David S. Paul, Eva Caparros, Verónica Palma-Barqueros, Margarida Coucelo, Dalila Marques, Francisca Ferrer-Marín, José Ramón González-Porras, Vicente Vicente, Jesús María Hernández-Rivas, Steve P. Watson, María Luisa Lozano, Wolfgang Bergmeier, José Rivera
Publikováno v:
Platelets, Vol 29, Iss 2, Pp 192-195 (2018)
The RASGRP2 gene encodes the Ca2+ and DAG-regulated guanine nucleotide exchange factor I (CalDAG-GEFI), which plays a key role in integrin activation in platelets and neutrophils. We here report two new RASGRP2 variants associated with platelet dysfu
Externí odkaz:
https://doaj.org/article/dc09b8ebe4b3487594e213cdbf6719ad
Autor:
David S. Paul, Caterina Casari, Congying Wu, Raymond Piatt, Swetha Pasala, Robert A. Campbell, Kathryn O. Poe, Dorsaf Ghalloussi, Robert H. Lee, Jeremy D. Rotty, Brian C. Cooley, Kellie R. Machlus, Joseph E. Italiano, Jr, Andrew S. Weyrich, James E. Bear, Wolfgang Bergmeier
Publikováno v:
Blood Advances, Vol 1, Iss 18, Pp 1398-1408 (2017)
Abstract: Actin reorganization regulates key processes in platelet activation. Here we examined the role of the Arp2/3 complex, an essential component in actin filament branching, in platelet function. The Arpc2 gene, encoding the p34 subunit of the
Externí odkaz:
https://doaj.org/article/44144d7cf1194f29b42a8abe4531b894
Autor:
Emilse Bermejo, Maria F. Alberto, David S. Paul, Aaron A. Cook, Paquita Nurden, Analia Sanchez Luceros, Alan T. Nurden, Wolfgang Bergmeier
Publikováno v:
Platelets, Vol 29, Iss 1, Pp 84-86 (2018)
Congenital platelet function disorders are often the result of defects in critical signal transduction pathways required for platelet adhesion and clot formation. Mutations affecting RASGRP2, the gene encoding the Rap GTPase activator, CalDAG-GEFI, g
Externí odkaz:
https://doaj.org/article/a7b7754dc5cb4cefa0780ee777b732fd
Autor:
Wei Deng, Yan Xu, Wenchun Chen, David S. Paul, Anum K. Syed, Matthew A. Dragovich, Xin Liang, Philip Zakas, Michael C. Berndt, Jorge Di Paola, Jerry Ware, Francois Lanza, Christopher B. Doering, Wolfgang Bergmeier, X. Frank Zhang, Renhao Li
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the pl
Externí odkaz:
https://doaj.org/article/cca6cab2d9084967958579b065cd46c9
Autor:
Oscar Negrón, Woosuk S Hur, Joni Prasad, David S Paul, Sarah E Rowe, Jay L Degen, Sara R Abrahams, Silvio Antoniak, Brian P Conlon, Wolfgang Bergmeier, Magnus Hӧӧk, Matthew J Flick
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010227 (2022)
The blood-clotting protein fibrin(ogen) plays a critical role in host defense against invading pathogens, particularly against peritoneal infection by the Gram-positive microbe Staphylococcus aureus. Here, we tested the hypothesis that direct binding
Externí odkaz:
https://doaj.org/article/1cdfdde0a1ee486a8eb41935fd614820
Autor:
Tomohiro Kawano, Yohei Hisada, Steven P. Grover, Wyatt J. Schug, David S. Paul, Wolfgang Bergmeier, Nigel Mackman
Publikováno v:
Thrombosis and Haemostasis. 123:501-509
Cancer patients have increased thrombosis and bleeding compared with the general population. Cancer is associated with activation of both platelets and coagulation. Mouse models have been used to study the dysregulation of platelets and coagulation i
Autor:
David S. Paul, Tasha N. Blatt, Wyatt J. Schug, Emily G. Clark, Tomohiro Kawano, Nigel Mackman, Sebastian Murcia, Kathryn O. Poe, Jean Marie N. Mwiza, T. Kendall Harden, Wolfgang Bergmeier, Robert A. Nicholas
Publikováno v:
Journal of Thrombosis and Haemostasis.
Autor:
Woosuk S. Hur, David S. Paul, Emma G. Bouck, Oscar A. Negrón, Jean-Marie Mwiza, Lauren G. Poole, Holly M. Cline-Fedewa, Emily G. Clark, Lih Jiin Juang, Jerry Leung, Christian J. Kastrup, Tatiana P. Ugarova, Alisa S. Wolberg, James P. Luyendyk, Wolfgang Bergmeier, Matthew J. Flick
Publikováno v:
Blood. 139:1374-1388
Genetic variants within the fibrinogen Aα chain encoding the αC-region commonly result in hypodysfibrinogenemia in patients. However, the (patho)physiological consequences and underlying mechanisms of such mutations remain undefined. Here, we gener
Autor:
Jean Marie N. Mwiza, Robert H. Lee, David S. Paul, Lori A. Holle, Brian C. Cooley, Bernhard Nieswandt, Wyatt J. Schug, Tomohiro Kawano, Nigel Mackman, Alisa S. Wolberg, Wolfgang Bergmeier
Publikováno v:
Blood
Platelets are critical in hemostasis and a major contributor to arterial thrombosis (AT). (Pre)clinical studies suggest platelets also contribute to venous thrombosis (VT), but the mechanisms are largely unknown. We hypothesized that in VT, platelets