Zobrazeno 1 - 10
of 76
pro vyhledávání: '"David S. Moura"'
Autor:
Yi Li, Jose L. Mondaza-Hernandez, David S. Moura, Alexey S. Revenko, Angelica Tolentino, John T. Nguyen, Nam Tran, Clark A. Meyer, Jose Merino-Garcia, Rafael Ramos, Davide Di Lernia, Javier Martin-Broto, Heather N. Hayenga, Leonidas Bleris
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102154- (2024)
Solitary fibrous tumor (SFT) is a rare, non-hereditary soft tissue sarcoma thought to originate from fibroblastic mesenchymal stem cells. The etiology of SFT is thought to be due to an environmental intrachromosomal gene fusion between NGFI-A-binding
Externí odkaz:
https://doaj.org/article/5d8f5d5b1be74d249583ba786160cba2
Autor:
Javier Martin-Broto, Jeronimo Martinez-Garcia, David S. Moura, Andres Redondo, Antonio Gutierrez, Antonio Lopez-Pousa, Javier Martinez-Trufero, Isabel Sevilla, Roberto Diaz-Beveridge, Maria Pilar Solis-Hernandez, Amancio Carnero, Marco Perez, David Marcilla, Jesus Garcia-Foncillas, Pablo Romero, Javier Fernandez-Jara, Daniel Lopez-Lopez, Ivan Arribas, Nadia Hindi
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more c
Externí odkaz:
https://doaj.org/article/0c66d90901d244e6922dd1f9ea0a3f1f
Autor:
Jaime Carrillo-García, Serena Lacerenza, Nadia Hindi, Irene Carrasco García, Gloria Marquina, Juana María Cano Cano, Javier Martínez Trufero, Alberto Rafael Sevillano Tripero, Tania Luis García, Manuel Jorge Cuesta Rioboo, David S. Moura, Marta Renshaw, Jose L. Mondaza-Hernández, Davide Di Lernia, Antonio Gutierrez, Javier Martin-Broto
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background and objectives: Social distancing and quarantine implanted during the COVID-19 outbreak could have delayed the accession of oncologic patients to hospitals and treatments. This study analysed the management of sarcoma patients during this
Externí odkaz:
https://doaj.org/article/4176abcd3fc94b44bd8251892b02ec4b
Autor:
Javier Martin-Broto, Alicia Olarte-García, Ricardo Fernandéz-Rodríguez, Marta Ribeiro Ferreira, Irene Carrasco-García, Fernando Galvez-Montosa, Inmaculada Rincon-Perez, Javier Peinado-Serrano, Ignacio Azinovic, Laura Guzman-Gomez, Lurdes Salgado, Alberto Sevillano, Justo Ortega, Cristina Alvarez, Antonio Gutierrez, David S. Moura, Nadia Hindi
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background and objectives: Dimensional response is an unmet need in second lines of advanced soft tissue sarcomas (STS). Indeed, the three approved drugs, pazopanib, trabectedin, and eribulin, achieved an overall response rate (ORR) of less than 10%.
Externí odkaz:
https://doaj.org/article/1475ef79f82c4873859ed0806a878ff3
Autor:
Javier Martin-Broto, Claudia Valverde, Nadia Hindi, Bruno Vincenzi, Javier Martinez-Trufero, Giovanni Grignani, Antoine Italiano, Javier Lavernia, Ana Vallejo, Paolo Dei Tos, Francois Le Loarer, Ricardo Gonzalez-Campora, Rafael Ramos, Diana Hernández-Jover, Antonio Gutierrez, Cesar Serrano, Maria Monteagudo, Rocio Letón, Mercedes Robledo, David S. Moura, Marta Martin-Ruiz, Jose A. López-Guerrero, Julia Cruz, Antonio Fernandez-Serra, Jean-Yves Blay, Elena Fumagalli, Virginia Martinez-Marin
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-8 (2023)
Abstract Background Approximately 15% of adult GIST patients harbor tumors that are wild-type for KIT and PDGFRα genes (KP-wtGIST). These tumors usually have SDH deficiencies, exhibit a more indolent behavior and are resistant to imatinib. Underlyin
Externí odkaz:
https://doaj.org/article/da2ebd0056004ea28583248f6fd4476c
Autor:
Javier Martin-Broto, Andres Redondo, David S. Moura, Claudia Valverde, Jose Manuel Morales, Antonio Lopez-Pousa, Javier Martinez-Trufero, Antonio Gutierrez, Roberto Díaz-Beveridge, Pablo Luna, Virginia Martinez-Marin, David Marcilla, Ivan Arribas, Patricio Ledesma, Jose Antonio Lopez-Martin, Davide Di Lernia, Jorge Zamora, Nadia Hindi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In patients with progressive and symptomatic desmoid fibromatosis (DF) treatment with chemotherapy is typically prolonged, while surgery carries a high risk of relapse. Here, the authors report the results of a phase II clinical trial of short-course
Externí odkaz:
https://doaj.org/article/fa55a5db19834abd945515a13986f8dd
Autor:
Carlos Torrado, Melisa Camaño, Nadia Hindi, Justo Ortega, Alberto R. Sevillano, Gema Civantos, David S. Moura, Alessandra Dimino, Javier Martín-Broto
Publikováno v:
Cancers, Vol 15, Iss 21, p 5187 (2023)
Granular cell tumors (GCT) represent 0.5% of all soft tissue sarcomas (STS), and when metastatic, they exhibit aggressive behavior and determine limited survival. Metastatic GCTs are relatively chemo-resistant; however, there is growing evidence of t
Externí odkaz:
https://doaj.org/article/3746f4d7c8d243498dbd44528c07e1f6
Autor:
David S. Moura, Maria Peña‐Chilet, Juan Antonio Cordero Varela, Ramiro Alvarez‐Alegret, Carolina Agra‐Pujol, Francisco Izquierdo, Rafael Ramos, Luis Ortega‐Medina, Francisco Martin‐Davila, Carolina Castilla‐Ramirez, Carmen Nieves Hernandez‐Leon, Cleofe Romagosa, Maria Angeles Vaz Salgado, Javier Lavernia, Silvia Bagué, Empar Mayodormo‐Aranda, Luis Vicioso, Jose Emilio Hernández Barceló, Jordi Rubio‐Casadevall, Ana deJuan, Maria Concepcion Fiaño‐Valverde, Nadia Hindi, Maria Lopez‐Alvarez, Serena Lacerenza, Joaquin Dopazo, Antonio Gutierrez, Rosa Alvarez, Claudia Valverde, Javier Martinez‐Trufero, Javier Martín‐Broto
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3691-3705 (2021)
Predictive biomarkers of trabectedin represent an unmet need in advanced soft‐tissue sarcomas (STS). DNA damage repair (DDR) genes, involved in homologous recombination or nucleotide excision repair, had been previously described as biomarkers of t
Externí odkaz:
https://doaj.org/article/97947f91b0b04bea97667fd90e9fbdb6
Autor:
Yi Li, John T. Nguyen, Manasvini Ammanamanchi, Zikun Zhou, Elijah F. Harbut, Jose L. Mondaza-Hernandez, Clark A. Meyer, David S. Moura, Javier Martin-Broto, Heather N. Hayenga, Leonidas Bleris
Publikováno v:
Cancers, Vol 15, Iss 12, p 3127 (2023)
Solitary fibrous tumor (SFT) is a rare soft-tissue sarcoma. This nonhereditary cancer is the result of an environmental intrachromosomal gene fusion between NAB2 and STAT6 on chromosome 12, which fuses the activation domain of STAT6 with the repressi
Externí odkaz:
https://doaj.org/article/de70d3ef87b24709a2afd4375dd51cb5
Autor:
Andrea Napolitano, David S. Moura, Nadia Hindi, José L Mondaza-Hernandez, José A. Merino-Garcia, Rafael Ramos, Gian Paolo Dagrada, Silvia Stacchiotti, Francesco Graziano, Bruno Vincenzi, Javier Martin-Broto
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Background: Solitary fibrous tumours (SFT) are soft tissue sarcomas molecularly defined by the presence of the NAB2::STAT6 intrachromosomal fusion gene. Recently, a prospective phase II trial evaluating the role of the antiangiogenic tyrosine kinase
Externí odkaz:
https://doaj.org/article/c5c4cc310572489188a815d2101aedcc