Zobrazeno 1 - 10
of 34
pro vyhledávání: '"David S. Loose-Mitchell"'
Autor:
Russell Broaddus, Peter J.A. Davies, James H. Pickar, David S. Loose-Mitchell, Lei Deng, George M. Stancel, Gregory L. Shipley
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:2157-2163
To determine whether estrogen regulates retinoic acid (RA) production and signaling in the human endometrium as it does in the rodent uterus, we investigated the effects of estrogens on the expression of RA-metabolizing enzymes, retinoid receptors, a
Publikováno v:
Biology of Reproduction. 51:319-326
To explore the ability of androgens to affect gene expression in Sertoli and peritubular cells in vitro, constitutively expressed pSV,-Luc and a regulated reporter containing an androgen response element (MMTV-Luc) were transiently transfected into t
Publikováno v:
Critical Reviews in Eukaryotic Gene Expression. 4:55-116
In this article we have attempted to review the literature on the regulation of nuclear protooncogene expression by steroid hormones and other small molecules that interact with receptors of the steroid/thyroid superfamily. Until about 5 years ago, t
Publikováno v:
Biochemical and Biophysical Research Communications. 190:406-411
The gene of human prostaglandin H synthase-1 (PGHS-1,EC 1.14.99.1) was isolated from a human cosmid library and was contained in two overlapping clones. Multiple transcriptional start sites were identified. The major one located 136 bases upstream fr
Autor:
Jacques M. Lemire, David S. Loose-Mitchell, Robert C. Scott, Richard B. Weinberg, Dora D. Rogers, Ronald J. Portman
Publikováno v:
Kidney International. 42(5):1238-1246
Decreased low density lipoprotein receptor function and mRNA levels in lymphocytes from uremic patients. The mechanisms by which renal failure causes hyperlipoproteinemia remain unclear. To investigate the potential role of the low-density lipoprotei
Autor:
Salman M. Hyder, Zafar Nawaz, David S. Loose-Mitchell, George M. Stancel, Donald P. McDonnell
Publikováno v:
Journal of Biological Chemistry. 267:18047-18054
We have used transient transfection assays with reporter plasmids expressing chloramphenicol acetyltransferase, linked to regions of mouse c-fos, to identify a specific estrogen response element (ERE) in this protooncogene. This element is located in
Publikováno v:
Current Opinion in Lipidology. 3:179-185
The major species which serve as models for the study of plasma lipoproteins as well as atherosclerosis include rabbits, hamsters, mice, rats, pigs, and non-human primates. However, since no single species has all of the desired attributes which woul
Autor:
Constance Chiappetta, David S. Loose-Mitchell, John L. Kirkland, George M. Stancel, Lata Murthy
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 41:113-123
Treatment of immature female rats with estradiol increases uterine levels of c-jun and jun-B mRNAs approx. 10-fold. This effect is specific for estrogenic steroids. The induction of jun transcripts is blocked by actinomycin D but not puromycin, sugge
Publikováno v:
Steroids. 56:498-504
We have previously shown that the intracellular content of c -fos mRNA is rapidly induced (within 1 to 3 hours) in ovariectomized rat or mouse uteri following administration of estradiol. This induction is sensitive to actinomycin D but not to protei
Autor:
Joel D. Morrisett, Julie A. Poorman, David S. Loose-Mitchell, Maurizio Soma, Antonio M. Gotto, S. A. Smith, Merrill Overturf
Publikováno v:
Journal of Lipid Research, Vol 31, Iss 6, Pp 985-994 (1990)
We have previously described a colony of New Zealand White rabbits that are resistant to hypercholesterolemia when fed a cholesterol-enriched diet. The present studies used skin fibroblasts obtained from normal and hypercholesterolemia-resistant rabb