Zobrazeno 1 - 10
of 113
pro vyhledávání: '"David S. Leake"'
Autor:
Feroz Ahmad, Robert D. Mitchell, Tom Houben, Angela Palo, Tulasi Yadati, Andrew J. Parnell, Ketan Patel, Ronit Shiri‐Sverdlov, David S. Leake
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
Background We have shown previously that low‐density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in lysosomes, and that this drug decreases a
Externí odkaz:
https://doaj.org/article/fda9f1c4cdf04659bffbd7796e762592
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3083 (2022)
Atherosclerosis, the major cause of vascular disease, is an inflammatory process driven by entry of blood monocytes into the arterial wall. LDL normally enters the wall, and stimulates monocyte adhesion by forming oxidation products such as oxidised
Externí odkaz:
https://doaj.org/article/07dc9db0a3fc403993a3c2ca9ea537f3
Autor:
Feroz Ahmad, David S. Leake
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 1, Pp 98-110 (2019)
We have shown that aggregated LDL is internalized by macrophages and oxidized in lysosomes by redox-active iron. We have now investigated to determine whether the lysosomal oxidation of LDL impairs lysosomal function and whether a lysosomotropic anti
Externí odkaz:
https://doaj.org/article/18c7dcbbe9bb4a06b4e5f0d22a88d547
Autor:
Andrew B. Gerry, David S. Leake
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 4, Pp 782-789 (2008)
We investigated the effect of pH on macrophage apoptosis induced by oxidized low density lipoprotein (OxLDL), as human atherosclerotic lesions have regions of low pH. Hydroperoxide-rich and oxysterol-rich LDL caused 38% and 74% apoptosis of J774 macr
Externí odkaz:
https://doaj.org/article/4f6cee1f804641b88d4caf6f55b44826
Saturated fat-induced changes in Sf 60–400 particle composition reduces uptake of LDL by HepG2 cells
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 2, Pp 393-403 (2006)
The ability of human postprandial triacylglycerol-rich lipoproteins (TRLs), isolated after meals enriched in saturated fatty acids (SFAs), n-6 PUFAs, and MUFAs, to inhibit the uptake of 125I-labeled LDL by the LDL receptor was investigated in HepG2 c
Externí odkaz:
https://doaj.org/article/d1ae3add5caf4a979464ea3111a7835a
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 3, Pp 512-521 (2003)
Oxidized LDL is present within atherosclerotic lesions, demonstrating a failure of antioxidant protection. A normal human serum ultrafiltrate of Mr below 500 was prepared as a model for the low Mr components of interstitial fluid, and its effects on
Externí odkaz:
https://doaj.org/article/adf360865a1f4bbe9b6e6f5c4b36d124
Autor:
Oluwatosin O. Ojo, David S. Leake
Publikováno v:
Free Radical Research. 56:436-446
We have previously demonstrated that low-density lipoprotein (LDL) can be oxidized by iron in the lysosomes of macrophages. Some of the iron content of lysosomes might be delivered through autophagy of ferritin (the main iron-storage protein in the b
Autor:
Oluwatosin O. Ojo, David S. Leake
Publikováno v:
Free Radical Research. 55:525-534
Low density lipoprotein (LDL) might be oxidised by iron in the lysosomes of macrophages in atherosclerotic lesions. We have shown previously that the iron-storage protein ferritin can oxidise LDL at lysosomal pH. We have now investigated the roles of
Autor:
Hadeel K M Alboaklah, David S. Leake
Publikováno v:
Free Radical Research. 54:574-584
Many cholesterol-laden foam cells in atherosclerotic lesions are macrophages and much of their cholesterol is present in their lysosomes and derived from low density lipoprotein (LDL). LDL oxidation has been proposed to be involved in the pathogenesi
Autor:
David S. Leake, Ketan Patel, Feroz Ahmad, Angela Palo, Ronit Shiri-Sverdlov, Tom Houben, Tulasi Yadati, Andrew J Parnell, Robert Mitchell
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
Journal of the American Heart Association, 10(18):e017524. Wiley
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, 10(18):e017524. Wiley
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We have shown previously that low‐density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in lysosomes, and that this drug decreases a