Zobrazeno 1 - 10
of 61
pro vyhledávání: '"David S. Garvey"'
Autor:
Allison M. Martino, James L Ellis, Irina S. Zemtseva, Roseanne S. Wexler, Joseph D. Schroeder, Steward K Richardson, David R. Janero, L. Gordon Letts, Shiow-Jyi Wey, Madhavi G. Murty, Michael E. Augustyniak, William M. Selig, David S. Garvey, A. Mark Trocha, Brian M. Zifcak, Edward Cochran, Terry L. Melim, Delano V. Young, Xinqin Fang
Publikováno v:
Journal of Medicinal Chemistry. 50:6367-6382
Indomethacin, a nonselective cyclooxygenase (COX) inhibitor, was modified in three distinct regions in an attempt both to increase cyclooxygenase-2 (COX-2) selectivity and to enhance drug safety by covalent attachment of an organic nitrate moiety as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94044af8d585684900ddd50e7efcb734
https://doi.org/10.1021/jm0611861
https://doi.org/10.1021/jm0611861
Publikováno v:
Current Topics in Medicinal Chemistry. 7:311-340
In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of phospholipase A2 and the release of arachidonic acid (AA) from membrane phospholipids. The AA is subsequently transformed by cyclooxygenase (COX) and lipoxygenase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb23434675230234f22b78c52225c4c
https://doi.org/10.2174/156802607779941314
https://doi.org/10.2174/156802607779941314
Publikováno v:
Tetrahedron. 62:8410-8418
The development and preparation of five series of tertiary thiols and nitrosothiols as nitric oxide releasing molecules functionalized with acid, alcohol, or amine groups for future conjugation are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::051dd1f562ef4ef1219dcb83d3ac4d63
https://doi.org/10.1016/j.tet.2006.06.019
https://doi.org/10.1016/j.tet.2006.06.019
Autor:
A. Mark Trocha, David S. Garvey, Michael E. Augustyniak, Stewart K. Richardson, Mathew J. Shumway, David R. Janero, Delano V. Young, L. Gordon Letts, James L. Ellis, Ramani R. Ranatunge, Irina S. Zemtseva, Vijay Dhawan
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:2589-2599
A series of glycolamide naproxen prodrugs containing a nitrate group as a nitric oxide (NO) donor moiety has been synthesized. These compounds were evaluated for their anti-inflammatory activity, naproxen release, and gastric tolerance. Compounds 4a,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83310c66cd24419b8dc7b5347da6cce4
https://doi.org/10.1016/j.bmc.2005.11.040
https://doi.org/10.1016/j.bmc.2005.11.040
Autor:
Irina S. Zemtseva, Michael E. Augustyniak, Allison M. Martino, Richard A. Earl, Delano V. Young, L. Gordon Letts, Madhavi G. Murty, Matthew J. Shumway, David S. Garvey, David J. Schwalb, Subhash P. Khanapure, Andrzej M. Trocha, David R. Janero
Publikováno v:
Journal of Medicinal Chemistry. 48:3930-3934
Incorporation of a spacer group between the central scaffold and the aryl ring resulted in a new cyclooxygenase-2 (COX-2) selective inhibitor core structure, 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone (20), with COX-2 I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d453f918abf08e4f84b0a18119112c
https://doi.org/10.1021/jm0582064
https://doi.org/10.1021/jm0582064
Publikováno v:
Expert Opinion on Therapeutic Patents. 15:483-495
Arterial renarrowing (restenosis) limits balloon angioplasty’s therapeutic potential, despite the benefits of intravascular prosthetic devices called stents. Nitric oxide (NO) mediates/regulates diverse aspects of blood vessel function, and NO insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc451ea95006fb0da25716386b8f4ad3
https://doi.org/10.1517/13543776.15.5.483
https://doi.org/10.1517/13543776.15.5.483
Autor:
L. G. Letts, M. Ezawa, A. Martino, D. V. Young, David S. Garvey, R. R. Ranatunge, David R. Janero, S. P. Khanapure, D. J. Schwalb
Publikováno v:
Letters in Drug Design & Discovery. 2:40-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32c1c82525b3cf8f722701718f176244
https://doi.org/10.2174/1570180053398451
https://doi.org/10.2174/1570180053398451
Autor:
David R. Janero, Ramani R. Ranatunge, Matthew J. Shumway, Delano V. Young, James L. Ellis, Joseph D. Schroeder, S. William Tam, David S. Garvey, A. Mark Trocha, L. Gordon Letts, Madhavi G. Murty, Michael E. Augustyniak, Richard A. Earl, Upul K. Bandarage, Allison M. Martino, Stewart K. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 47:2180-2193
The synthesis of a series of novel pyrazoles containing a nitrate (ONO(2)) moiety as a nitric oxide (NO)-donor functionality is reported. Their COX-1 and COX-2 inhibitory activities in human whole blood are profiled. Our data demonstrate that pyrazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c82949f333971ca18cb6135ae949209
https://doi.org/10.1021/jm030276s
https://doi.org/10.1021/jm030276s
Autor:
L. Gordon Letts, Delano V. Young, Madhavi G. Murty, Stewart K. Richardson, Ramani R. Ranatunge, Allison M. Martino, David R. Janero, David S. Garvey, Irina S. Zemetseva
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:1357-1366
Novel series of pyrazolo[5,1- b ]1,3-oxazolidines, pyrazolo[5,1- b ]1,3-oxazines and imidazolidino[1,2- d ]pyrazoles were synthesized. These compounds were evaluated in vitro for their ability to inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6118b32f5cf2b3e31ef16a3317c727
https://doi.org/10.1016/j.bmc.2004.01.012
https://doi.org/10.1016/j.bmc.2004.01.012
Autor:
Upul K. Bandarage, Xinqin Fang, Alicia Glavin, David S. Garvey, Joy K. Saha, L. Gordon Letts, S. William Tam, Joseph D. Schroeder, Gregory J. Mercer, David R. Janero, Liqing Chen, Matthew J. Shumway
Publikováno v:
Journal of Medicinal Chemistry. 43:4005-4016
Despite its widespread use, diclofenac has gastrointestinal liabilities common to nonsteroidal antiinflammatory drugs (NSAIDs) that might be reduced by concomitant administration of a gastrointestinal cytoprotectant such as nitric oxide (NO). A serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7245897e4923564425e3b91415eb2b
https://doi.org/10.1021/jm000178w
https://doi.org/10.1021/jm000178w