Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David S. Breen"'
Autor:
Marin E. Nelson, Sujoy Lahiri, Jenny D. Y. Chow, Frances L. Byrne, Stefan R. Hargett, David S. Breen, Ellen M. Olzomer, Lindsay E. Wu, Gregory J. Cooney, Nigel Turner, David E. James, Jill K. Slack-Davis, Carolin Lackner, Stephen H. Caldwell, Kyle L. Hoehn
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The lipogenic pathway is often upregulated in liver tumours and regarded as a therapeutic target. Here, the authors show instead that blocking lipogenesis via knockout of acetyl-CoA carboxylase genes results in increased susceptibility to liver tumor
Externí odkaz:
https://doaj.org/article/19ef0685f5d74b788afe67c6f9e96489
Autor:
Carolin Lackner, Jenny D.Y. Chow, David S. Breen, Chien Li, Norbert Leitinger, Frances L. Byrne, Stephen H. Caldwell, Marin E. Healy, Kyle L. Hoehn
Publikováno v:
Journal of Hepatology. 62:599-606
Background & Aims Mice exposed to the hepatocellular carcinogen diethylnitrosamine at 2weeks of age have a high risk of developing primary liver tumors later in life. Previous studies have demonstrated that diethylnitrosamine-treated mice have increa
Autor:
Nigel Turner, Marin E. Nelson, Lindsay E. Wu, Ellen M. Olzomer, Stephen H. Caldwell, Carolin Lackner, David S. Breen, Jenny D.Y. Chow, Kyle L. Hoehn, Stefan R. Hargett, Gregory J. Cooney, Sujoy Lahiri, Frances L. Byrne, Jill K. Slack-Davis, David E. James
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
The metabolic pathway of de novo lipogenesis is frequently upregulated in human liver tumours, and its upregulation is associated with poor prognosis. Blocking lipogenesis in cultured liver cancer cells is sufficient to decrease cell viability; howev
Autor:
Kyle L. Hoehn, Brandon M. Kenwood, Valeria R. Mas, Robert T. Lawrence, David S. Breen, Frances L. Byrne, Gregory J. Cooney, Pere Puigserver, David E. James, Stephen H. Caldwell, Jenny D.Y. Chow, Jason A. Liao, Carolin Lackner, Saeko Okutsu, Jose L. Tomsig, John E. Dominy, Marin E. Healy, Nigel Turner, Judit Villén
Publikováno v:
Molecular Metabolism
Lipid deposition in the liver is associated with metabolic disorders including fatty liver disease, type II diabetes, and hepatocellular cancer. The enzymes acetyl-CoA carboxylase 1 (ACC1) and ACC2 are powerful regulators of hepatic fat storage; ther
Autor:
Mitsuharu Okutsu, Nicholas P. Greene, Vitor A. Lira, Mei Zhang, Kyle L. Hoehn, Rhianna C. Laker, David S. Breen, Zhen Yan
Publikováno v:
The FASEB Journal. 27:4184-4193
Pathological and physiological stimuli, including acute exercise, activate autophagy; however, it is unknown whether exercise training alters basal levels of autophagy and whether autophagy is required for skeletal muscle adaptation to training. We o
Autor:
Carolin Lackner, Frances L. Byrne, Jenny D.Y. Chow, Kyle L. Hoehn, David S. Breen, Brandon M. Kenwood, Stefan R. Hargett, Marin E. Healy, Evan P. Taddeo, Sujoy Lahiri, Stephen H. Caldwell
Publikováno v:
Scientific Reports
Overnutrition can promote liver cancer in mice and humans that have liver damage caused by alcohol, viruses, or carcinogens. However, the mechanism linking diet to increased liver tumorigenesis remains unclear in the context of whether tumorigenesis
Autor:
Jenny D.Y. Chow, Kevin R. Lynch, M. Chokki, Brandon M. Kenwood, Jose L. Tomsig, Rhianna C. Laker, David E. James, Evan P. Taddeo, Thurl E. Harris, Susanna R. Keller, Nigel Turner, Jason A. Liao, Yasir N. Akhtar, Mei Zhang, Zhen Yan, Jeffery D. Molkentin, David S. Breen, Daniel J. Fazakerley, Kyle L. Hoehn
Publikováno v:
Molecular metabolism. 3(2)
Insulin resistance is associated with mitochondrial dysfunction, but the mechanism by which mitochondria inhibit insulin-stimulated glucose uptake into the cytoplasm is unclear. The mitochondrial permeability transition pore (mPTP) is a protein compl