Zobrazeno 1 - 10
of 12
pro vyhledávání: '"David S. Block"'
Autor:
Hua Zhou, Henrik Olsen, Edward So, Emmanuel Mérigeon, Denis Rybin, Jane Owens, Gregory LaRosa, David S. Block, Scott E. Strome, Xiaoyu Zhang
Publikováno v:
Blood Advances, Vol 1, Iss 8, Pp 504-515 (2017)
Abstract: GL-2045 is a recombinant human immunoglobulin G1 (IgG1)–based Fc multimer designed to recapitulate the anti-inflammatory activities of intravenous immunoglobulin (IVIG) on the innate and adaptive immune responses. We used functional in vi
Externí odkaz:
https://doaj.org/article/93856454e7934fbba11284107095403d
Autor:
Scott E. Strome, Henrik S. Olsen, Haoping Sun, Xiaoyu Zhang, John C. Papadimitriou, Erin Burch, David S. Block, Edward So, Søren M. Bentzen, Susan Kinsey, Emmanuel Y. Mérigeon, Cinthia B. Drachenberg
Publikováno v:
Journal of Autoimmunity. 84:97-108
There is a lack of effective targeted therapies for the treatment of complement dependent diseases. We developed two recombinant Fc multimers, G207 and G211, with limited ability to interact with low/moderate affinity FcγRs, but with high avidity fo
Autor:
Gregory LaRosa, Hua Zhou, Edward So, Henrik S. Olsen, Denis Rybin, David S. Block, Xiaoyu Zhang, Jane Owens, Emmanuel Y. Mérigeon, Scott E. Strome
Publikováno v:
Blood Advances. 1:504-515
GL-2045 is a recombinant human immunoglobulin G1 (IgG1)-based Fc multimer designed to recapitulate the anti-inflammatory activities of intravenous immunoglobulin (IVIG) on the innate and adaptive immune responses. We used functional in vitro studies
Autor:
Henrik S. Olsen, Shaodong Chen, Erin Burch, Edward So, David S. Block, Emmanuel Y. Mérigeon, Scott E. Strome, Xiaoyu Zhang, Hua Zhou
Publikováno v:
The Journal of Immunology. 196:1165-1176
We developed a fully recombinant anti-CD20 protein derived from cDNA encoding one Fab domain, two IgG1 Fc regions, the IgG2 hinge, and an isoleucine zipper. This protein, called GB4542, contained both the homodimer and higher-order multimers. Binding
Autor:
Xiaoyu Zhang, Gregory Weber, David S. Block, Edward So, Erin Burch, Henrik S. Olsen, Xianfeng Li, Gregory LaRosa, Scott E. Strome, Haiping Hao, Mark C. McCroskey, Donald Bennett, Hua Zhou, Jane Owens, Emmanuel Y. Mérigeon, Denis Rybin
Publikováno v:
JCI insight. 4(2)
The antiinflammatory effects of i.v. Ig (IVIG) in the treatment of autoimmune disease are due, in part, to the Fc fragments of Ig aggregates. In order to capitalize on the known antiinflammatory and tolerogenic properties of Ig Fc aggregates, we crea
Autor:
William S. Twadell, Ling Cai, Edward So, Scott E. Strome, Xiaoyu Zhang, Dan H. Schulze, David S. Block, Bhawna Poonia, Erin Burch, Ajay N. Jain, Emmanuel Y. Mérigeon, Henrik S. Olsen, Nader Hanna, Harris G. Yfantis, Ravi Vyzasatya, Siaw L. Chan
Publikováno v:
European Journal of Cancer. 49:3344-3352
Tumour antigen targeted antibodies (mAbs) can induce natural killer (NK) cells to kill tumours through antibody dependent cellular cytotoxicity (ADCC) upon engagement of NK cell expressed FcγRIIIa. FcγRIIIa polymorphisms partially dictate the poten
Autor:
Geoffrey I. Scott, Michael H. Fulton, Edward F. Wirth, David C. Volz, David S Block, G. Thomas Chandler
Publikováno v:
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 133:419-434
Although much is known regarding photoperiodic effects on crustacean egg production, the effects of ultraviolet (UV) light on reproduction has not been investigated. Likewise, little is known concerning the interaction between UV and xenobiotic expos
Autor:
Ajay N. Jain, Emmanuel Y. Mérigeon, Scott E. Strome, Erin Burch, Dan H. Schulze, Koji Tamada, Changwan Lu, Yukimi Sakoda, Ming Tan, Ravi Vyzasatya, Ling Cai, David S. Block, Henrik S. Olsen
Publikováno v:
Arthritis Research & Therapy
Introduction: Soluble immune aggregates bearing intact Fc fragments are effective treatment for a variety of autoimmune disorders in mice. The better to understand the mechanisms by which Fc-bearing immune complexes suppress autoimmunity, and to deve
Autor:
Michael H. Fulton, David S Block, G. T. Chandler, John L. Ferry, D. C. Volz, Spencer S. Walse, E. F. Wirth, Geoffrey I. Scott, E. D. Strozier
Publikováno v:
Bulletin of environmental contamination and toxicology. 71(3)
Publikováno v:
General and comparative endocrinology. 132(1)
Endocrine function in arthropods has principally been characterized in insects and malacostracan crustaceans. However, meiofauna represent the most abundant metazoan marine taxa, with harpacticoid copepods comprising the second most abundant taxon. I