Zobrazeno 1 - 10
of 22
pro vyhledávání: '"David S. Bellows"'
Publikováno v:
Mol. BioSyst.. 10:128-137
The pleiotropic drug response (PDR) or multidrug resistance (MDR) are cellular defence mechanisms present in all species to deal with potential toxicity from environmental small molecule toxins or bioactives. The rapid induction of MDR by xenobiotics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d076d5114577e4230a8d1c720f5f68d
https://doi.org/10.1039/c3mb70351g
https://doi.org/10.1039/c3mb70351g
Autor:
Sonam Dolma, Emma Griffiths, Marcia Roy, Mike Tyers, Nick Jarvik, Jan Wildenhain, R. L. White, Michaela Spitzer, David S. Bellows, Gerard D. Wright
Publikováno v:
Scientific Data
The network structure of biological systems suggests that effective therapeutic intervention may require combinations of agents that act synergistically. However, a dearth of systematic chemical combination datasets have limited the development of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e050345db9ea09f6aaae92f757696010
https://doi.org/10.1038/sdata.2016.95
https://doi.org/10.1038/sdata.2016.95
Autor:
Natelle C. H. Quek, Dora C. Leahy, David S. Bellows, John H. Miller, Jacqueline M. Barber, Peter T. Northcote
Publikováno v:
Journal of Natural Products. 74:809-815
Spectroscopy-guided chemical analysis of a marine sponge from the genus Plakortis, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E-K (5-11), four of which incorporate various sulfur functionalities. The structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73a803df08106ba005d46772dfccf3d
https://doi.org/10.1021/np100868t
https://doi.org/10.1021/np100868t
Publikováno v:
Molecular bioSystems. 11(11)
Identifying Saccharomyces cerevisiae genome-wide gene deletion mutants that confer hypersensitivity to a xenobiotic aids the elucidation of its mechanism of action (MoA). However, the biological activities of many xenobiotics are masked by the pleiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a88b960374543db3dc9a6b51912af3
https://pubmed.ncbi.nlm.nih.gov/26381459
https://pubmed.ncbi.nlm.nih.gov/26381459
Autor:
J. Marie Hardwick, Iva Ivanovska, Ying Bei Chen, Valina L. Dawson, So Young Seo, Suk Jin Hong, Yihru Fannjiang, Stanley J. Korsmeyer, David S. Bellows, Ann M. Ranger
Publikováno v:
Journal of Biological Chemistry. 279:42240-42249
The mammalian BAD protein belongs to the BH3-only subgroup of the BCL-2 family. In contrast to its known pro-apoptotic function, we found that endogenous and overexpressed BAD(L) can inhibit cell death in neurons and other cell types. Several mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9639845bb8b633a9a344a74e9abef8
https://doi.org/10.1074/jbc.m406775200
https://doi.org/10.1074/jbc.m406775200
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1205
Chemogenomics is the systematic genome-wide study of the cellular response to small molecule agents. Modern high-throughput genetic techniques allow massively parallel examination of the genetic effects of such biologically active small molecules (BA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c2c33b311ddcb5dcccab9816ab49bd7
https://pubmed.ncbi.nlm.nih.gov/25213245
https://pubmed.ncbi.nlm.nih.gov/25213245
Publikováno v:
Methods in Molecular Biology ISBN: 9781493913626
Chemogenomics is the systematic genome-wide study of the cellular response to small molecule agents. Modern high-throughput genetic techniques allow massively parallel examination of the genetic effects of such biologically active small molecules (BA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ba947a625b525cd91002a9f69b5ed42
https://doi.org/10.1007/978-1-4939-1363-3_11
https://doi.org/10.1007/978-1-4939-1363-3_11
Antiapoptotic Herpesvirus Bcl-2 Homologs Escape Caspase-Mediated Conversion to Proapoptotic Proteins
Publikováno v:
Journal of Virology. 74:5024-5031
The antiapoptotic Bcl-2 and Bcl-x L proteins of mammals are converted into potent proapoptotic factors when they are cleaved by caspases, a family of apoptosis-inducing proteases (E. H.-Y. Cheng, D. G. Kirsch, R. J. Clem, R. Ravi, M. B. Kastan, A. Be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f909a9fc6e7462c158b50fa6a14882c
https://doi.org/10.1128/jvi.74.11.5024-5031.2000
https://doi.org/10.1128/jvi.74.11.5024-5031.2000
Autor:
Paul H. Atkinson, David S. Bellows, John H. Miller, Peter T. Northcote, Paul H. Teesdale-Spittle, David R. Maass, Reem Hanna
Publikováno v:
Molecular bioSystems. 10(1)
Baker's yeast, Saccharomyces cerevisiae, has significant sequence conservation with a core subset of mammalian proteins and can serve as a model for disease processes. The aim of this study was to determine whether yeast could be used as a model syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafd838cd6aa4595756ccc526fd3724f
https://pubmed.ncbi.nlm.nih.gov/24161989
https://pubmed.ncbi.nlm.nih.gov/24161989
Autor:
Paul H. Atkinson, Greta Moraes, Bede P. Busby, Rosemary W. Heathcott, Stephan Andreas Angermayr, David S. Bellows, Dora C. Leahy, James H. Matthews, Kristina Boeger, Alice G. Sorgo, Peter T. Northcote, Jacqueline M. Barber, Ploi Yibmantasiri
Publikováno v:
Molecular bioSystems. 8(3)
Neothyonidioside is a triterpene glycoside (TG) isolated from the sea cucumber, Australostichopus mollis, that is potently cytotoxic to S. cerevisiae, but does not permeabilize cellular membranes. We mutagenized S. cerevisiae and isolated a neothioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c76bdbc1c8ab84f83bfdb1f072325a
https://pubmed.ncbi.nlm.nih.gov/22271309
https://pubmed.ncbi.nlm.nih.gov/22271309