Zobrazeno 1 - 10
of 85
pro vyhledávání: '"David S. Thomson"'
Autor:
Demetrios Pagonis, Pedro Campuzano-Jost, Hongyu Guo, Douglas A. Day, Melinda K. Schueneman, Wyatt L. Brown, Benjamin A. Nault, Harald Stark, Kyla Siemens, Alex Laskin, Felix Piel, Laura Tomsche, Armin Wisthaler, Matthew M. Coggon, Georgios I. Gkatzelis, Hannah S. Halliday, Jordan E. Krechmer, Richard H. Moore, David S. Thomson, Carsten Warneke, Elizabeth B. Wiggins, Jose L. Jimenez
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41fb5be5b74f74f69db00acea0c65389
https://doi.org/10.5194/amt-2020-395-supplement
https://doi.org/10.5194/amt-2020-395-supplement
Publikováno v:
Expert opinion on investigational drugs. 28(5)
Background: An efficacious anti-inflammatory corticosteroid with reduced side effects has been long sought. We report the pooled results from three clinical proof-of-mechanism Phase I studies of BI 653048 in healthy subjects, a functionally selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011ab63c1e7d5652efe68b72be3036c2
https://pubmed.ncbi.nlm.nih.gov/30908082
https://pubmed.ncbi.nlm.nih.gov/30908082
Autor:
N. Kille, Sunil Baidar, David S. Thomson, James W. Hannigan, R. Sinreich, Rainer Volkamer, Ivan Ortega
Publikováno v:
Atmospheric Measurement Techniques, Vol 9, Iss 3, Pp 963-972 (2016)
We have constructed and deployed a fast digital solar tracker aboard a moving ground-based platform. The tracker consists of two rotating mirrors, a lens, an imaging camera, and a motion compensation system that provides the Euler angles of the mobil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591b7306dc1a9a0b89c1bb830159402d
http://www.atmos-meas-tech.net/9/963/2016/amt-9-963-2016.pdf
http://www.atmos-meas-tech.net/9/963/2016/amt-9-963-2016.pdf
Autor:
Monica Patel, Mita Patel, Thomas Wai-Ho Lee, John Lord, Brian Christopher Raudenbush, Heather Grbic, Hossein Razavi, Darren Disalvo, David Joseph, Maryanne L. Brown, Alan David Swinamer, Della White, Siqi Lin, Karen Berg, Alison Kukulka, David S. Thomson, Christopher Ronald Sarko, Kim Fletcher, Pingrong Liu, Can Mao, Laura Amodeo, Christian Harcken
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(3)
A HTS screen for CCR1 antagonists afforded a novel sub-micromolar hit 5 containing a pyrazole core. In this report the design, optimization, and SAR of novel CCR1 antagonists based on a pyrazole core motif is presented. Optimization led to the advanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e864650ab9ef4500685ce7b687049a7
https://pubmed.ncbi.nlm.nih.gov/30455146
https://pubmed.ncbi.nlm.nih.gov/30455146
Publikováno v:
Atmospheric Measurement Techniques. 8:2371-2395
We present an innovative instrument telescope and describe a retrieval method to probe three-dimensional (3-D) distributions of atmospheric trace gases that are relevant to air pollution and tropospheric chemistry. The University of Colorado (CU) two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b35dba9de0de4c57dba49b730adb9612
https://doi.org/10.5194/amt-8-2371-2015
https://doi.org/10.5194/amt-8-2371-2015
Autor:
Adam Flegg, Tina Morwick, Ho Yin Lo, Todd Bosanac, Weimin Liu, Valentina Berger, Steven Kerr, Stéphane De Lombaert, Paige Erin Mahaney, Ralph Binetti, John Broadwater, Spencer Napier, Alessandra Bartolozzi, Lifen Wu, Hidenori Takahashi, Asitha Abeywardane, Heather Tye, Tazmeen Fadra-Khan, John D. Huber, Adrian Kotey, Ming-Hong Hao, Dines Jonathon Alan, Anil Kumar Padyana, Alan Olague, Michael Garrigou, David S. Thomson, J. Matthew Hutzler, Pui Leng Loke, Renee Zindell, Edward Pack, Zhidong Chen, Rebecca Crux, Thomas Simpson, Rajvee Dave, Doris Riether
Publikováno v:
Journal of Medicinal Chemistry. 58:1669-1690
The synthesis, structure–activity relationship (SAR), and evolution of a novel series of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitors are described. The use of structure-guided drug design techniques provided compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec30afc1732226a8a2acaaba6be03b4
https://doi.org/10.1021/jm501185j
https://doi.org/10.1021/jm501185j
Publikováno v:
Light, Energy and the Environment.
Vertical column measurements of trace gases along the direct solar beam using airborne and mobile Solar Occultation Flux provide a tool to study emissions from area sources that can be directly compared with emission inventories.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7fd8db742c9b64f846c5f25e5df056c
https://doi.org/10.1364/ee.2017.eth1a.2
https://doi.org/10.1364/ee.2017.eth1a.2
Autor:
Usha R. Patel, Richard M. Nelson, Gerald Nabozny, Christian Harcken, Zhidong Chen, Ljiljana Zuvela-Jelaska, Donald Souza, Todd Bosanac, Alison Kukulka, Mita Patel, Thomas Wai-Ho Lee, Doris Riether, Mark Stephen Ralph, David S. Thomson, Tazmeen Fadra-Khan, Yancey David Ward, Hossein Razavi, Pingrong Liu
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1318-1323
A series of nonsteroidal "dissociated" glucocorticoid receptor agonists was optimized for drug-like properties such as cytochrome P450 inhibition, metabolic stability, aqueous solubility, and hERG ion channel inhibition. This effort culminated in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a0b3a664e8a09670118611ff93aeba
https://doi.org/10.1021/ml500387y
https://doi.org/10.1021/ml500387y
Autor:
Michel J. Emmanuel, Jonathan T. Reeves, Christian Harcken, Raj Betageri, Richard M. Nelson, Jörg Bentzien, Gerald Nabozny, Alison Kukulka, Ljiljana Zuvela-Jelaska, Tazmeen N. Fadra, Roger M. Dinallo, Donald Souza, Doris Riether, Mark Stephen Ralph, David S. Thomson, Angela Berry, Daniel Kuzmich, Pingrong Liu
Publikováno v:
Journal of Medicinal Chemistry. 57:1583-1598
Synthesis and structure-activity relationship (SAR) of a series of nonsteroidal glucocorticoid receptor (GR) agonists are described. These compounds contain "diazaindole" moieties and display different transcriptional regulatory profiles in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e6fcde7b564a7f668cbef134972ed1
https://doi.org/10.1021/jm4019178
https://doi.org/10.1021/jm4019178
Autor:
Christian Harcken, Richard M. Nelson, Daniel Kuzmich, Tazmeen Fadra-Khan, Edward Pack, Jörg Bentzien, Donald Souza, Darren Disalvo, Alison Kukulka, David S. Thomson, Raj Betageri, Gerald Nabozny
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6640-6644
A class of α-methyltryptamine sulfonamide glucocorticoid receptor (GR) modulators was optimized for agonist activity. The design of ligands was aided by molecular modeling, and key function-regulating pharmacophoric points were identified that are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373ffd38700c5c8cbd1180416e3625b3
https://doi.org/10.1016/j.bmcl.2013.10.052
https://doi.org/10.1016/j.bmcl.2013.10.052