Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David S Thorpe"'
Autor:
Elisabeth Defossa, Matthias Löhn, Matthias Schäfer, Pavel Safar, Dietmar Weitz, Kristin Breitschopf, Matthias Lohmann, María Méndez, David S Thorpe, Jens Riedel, Nils Rackelmann, Hartmut Mors, Hans Matter, Michael Kurz, Ziyu Li, Michael Podeschwa, Sylvain Lebreton
Publikováno v:
Journal of Medicinal Chemistry. 63:2292-2307
The therapeutic success of peptidic GLP-1 receptor agonists for treatment of type 2 diabetes mellitus (T2DM) motivated our search for orally bioavailable small molecules that can activate the GLP-1 receptor (GLP-1R) as a well-validated target for T2D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dde87dac749897ba8532f58a4dc0ec6
https://doi.org/10.1021/acs.jmedchem.9b01071
https://doi.org/10.1021/acs.jmedchem.9b01071
Publikováno v:
Biochemical and Biophysical Research Communications. 218:670-673
The enzymatic properties of a cloned atrial natriuretic peptide receptor are described. The renatured catalytic core had maximal activity with Mn 2+ , and all nucleoside triphosphates inhibited the enzyme competitively. The catalytic specificity of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bb42ef0dbaae1301482a5464c72da9
https://doi.org/10.1006/bbrc.1996.0120
https://doi.org/10.1006/bbrc.1996.0120
Publikováno v:
Biochemical and Biophysical Research Communications. 180:538-544
Summary Using a bacterial expression system, large amounts of the catalytic core of an atrial natriuretic peptide receptor guanylyl cyclase were produced and purified. After refolding the protein from a buffer containing urea, the enzyme had positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0550f7001c939bdb9a1036769a68649
https://doi.org/10.1016/s0006-291x(05)81098-8
https://doi.org/10.1016/s0006-291x(05)81098-8
Autor:
David S. Thorpe
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46392922290c3931e3252e48bb4553b9
https://doi.org/10.1002/chin.200426237
https://doi.org/10.1002/chin.200426237
Autor:
Arun Kumar, David S Thorpe
Publikováno v:
Applications of Advanced Technologies in Transportation (2002).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f1962bc167c0692594ce9bfa3f45ad5
https://doi.org/10.1061/40632(245)73
https://doi.org/10.1061/40632(245)73
Autor:
Stefan Walle, David S. Thorpe
Publikováno v:
Biochemical and biophysical research communications. 269(2)
Affinity chromatography and the binding of soluble target proteins to novel or known ligands attached to solid supports are important phenomena to basic and applied research. Satisfactory display of a ligand for the acceptor protein is critical for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773a66b4873f24550de5d97178ba5299
https://pubmed.ncbi.nlm.nih.gov/10708599
https://pubmed.ncbi.nlm.nih.gov/10708599
Autor:
L.Charlie Chen, Kenneth F. Wertman, James Spoonamore, Anna Robinson, Sydney Wilson, David S. Thorpe, Alan Binnie, Martha Ackerman-Berrier, Shelly Wade, Stefan Walle, Helen Yeoman, Qinyuan (Quincey) Wu, A.W. Edith Chan, David Rodwell
Publikováno v:
Biochemical and biophysical research communications. 266(1)
Living systems are mainly composed and regulated by compounds in four biochemical classes and their polymers-nucleotides, carbohydrates, lipids, and amino acids. Early combinatorial chemistry libraries consisted of peptides. The present report descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2aed05297a40e05f3769a30bd51c10
https://pubmed.ncbi.nlm.nih.gov/10581165
https://pubmed.ncbi.nlm.nih.gov/10581165
Publikováno v:
Biochemical and biophysical research communications. 256(3)
Among cell adhesion molecules, the classic Arg-Gly-Asp (RGD) motif is the best studied. We used combinatorial chemical and affinity immunochemical methods to find a novel motif of unnatural peptide ligands for the fibrinogen receptor of platelets, gp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2856c484b7d8eab046ba2cae4bd506
https://pubmed.ncbi.nlm.nih.gov/10080933
https://pubmed.ncbi.nlm.nih.gov/10080933
Autor:
David S Thorpe
Publikováno v:
The Quarterly Review of Biology. 77:451-451
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d6dbdbf9d0eb1e9260ed2326be99387
https://doi.org/10.1086/374451
https://doi.org/10.1086/374451