Zobrazeno 1 - 10
of 145
pro vyhledávání: '"David S Small"'
Publikováno v:
British Journal of Clinical Pharmacology
AIMS To evaluate the pharmacokinetics and safety of once-daily (QD) tadalafil in paediatric patients with pulmonary arterial hypertension (PAH) to establish an appropriate dose range for further research. METHODS This was an open-label, multicentre,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83656386a8d888cdd0f78f6e452ef525
https://doi.org/10.1111/bcp.14039
https://doi.org/10.1111/bcp.14039
Publikováno v:
Clinical pharmacokinetics. 61(2)
Tadalafil 40 mg once daily is approved for adult patients with pulmonary arterial hypertension (PAH). To investigate and potentially fulfill an unmet need in pediatric patients with PAH, pharmacokinetic (PK) data were explored in a pediatric phase Ib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e48d484da82edf69c59a6a18ba9d31
https://pubmed.ncbi.nlm.nih.gov/34379314
https://pubmed.ncbi.nlm.nih.gov/34379314
Autor:
Ming-Dauh Wang, Yimin Cui, David S. Small, Jian Jun Jin, Yan Liang, Jeffrey G. Suico, Ping Xin, Ellen A. Cannady, Xia Zhao
Publikováno v:
International Journal of Pharmacokinetics. 3:69-80
Aim: Evaluate steady-state pharmacokinetics and potential interactions between select statins and evacetrapib. Patients & methods: This open-label, two-part study included 62 healthy native Chinese subjects. Part 1 evaluated pharmacokinetics and phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f44977484031daa2a6ed1a865153aad
https://doi.org/10.4155/ipk-2017-0017
https://doi.org/10.4155/ipk-2017-0017
Autor:
Brian A. Moser, Joseph A. Jakubowski, David S. Small, Emmanuel Chigutsa, Elizabeth Smith Labell
Publikováno v:
Clinical Pharmacokinetics. 57:243-254
Prasugrel, a P2Y12 adenosine diphosphate (ADP) receptor antagonist, inhibits ADP-mediated platelet activation and aggregation in patients with sickle cell anemia (SCA). We developed a population pharmacokinetic (popPK) model in pediatric patients fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680f8a9c03e9e7bbdd9dfa7e91ed3f42
https://doi.org/10.1007/s40262-017-0556-y
https://doi.org/10.1007/s40262-017-0556-y
Autor:
Demetrio Ortega, Wei Zhang, David S. Small, Jeffrey G. Suico, Jane Royalty, Ellen A. Cannady, Delyn Downs
Publikováno v:
European Journal of Clinical Pharmacology
Purpose The aim of this study is to investigate the effect of hepatic or renal impairment on the pharmacokinetics of a single 130-mg evacetrapib dose. Methods Two open-label, parallel-design studies in males and females with normal hepatic function o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1194b09dc1d9926760e89ed5d5100b80
https://doi.org/10.1007/s00228-016-2017-1
https://doi.org/10.1007/s00228-016-2017-1
Publikováno v:
The Journal of Sexual Medicine. 13:187-193
Introduction Testosterone 2% solution (Axiron) applied to armpit(s) is used for replacement therapy in men with a deficiency of endogenous testosterone. Aim To determine the amount of testosterone on subjects' T-shirts 12 hours after applying testost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174a79744c0937253ed988973eeb0579
https://doi.org/10.1016/j.jsxm.2015.12.007
https://doi.org/10.1016/j.jsxm.2015.12.007
Autor:
Boris A. Czeskis, Demetrio Ortega, Brian W. Pack, Aktham Aburub, Chris Ward, David S. Small, Ellen A. Cannady, Syeda L. Begum, William F. Annes, Jane Royalty, Qun Lin, Kenneth J. Ruterbories, Chris Hinds, Jeffrey G. Suico
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:238-244
This open-label, single-period study in healthy subjects estimated evacetrapib absolute bioavailability following simultaneous administration of a 130-mg evacetrapib oral dose and 4-h intravenous (IV) infusion of 175 µg [(13) C8 ]-evacetrapib as a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4beba73882159abdad3afbae34cd3e4d
https://doi.org/10.1002/jlcr.3358
https://doi.org/10.1002/jlcr.3358
Autor:
Delyn Downs, Jane Royalty, David S. Small, Ellen A. Cannady, Jeffrey G. Suico, Wei Zhang, Stuart Friedrich
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics
Purpose: To determine the effect of a high-fat meal on evacetrapib exposure at steady state in healthy participants. Methods: This was a randomized, 2-period, 2-sequence, open-label, crossover study. Patients were randomly assigned to 1 of the 2 trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d327f9e7ce86be6c7afeebe081c2ec12
https://doi.org/10.1177/1074248415575153
https://doi.org/10.1177/1074248415575153
Autor:
Nathan Bryan Mantlo, Stephen D. Hall, Stuart Friedrich, Matthew Rotelli, Alice Ban Ke, David S. Small
Publikováno v:
The Journal of Clinical Pharmacology. 55:757-767
Anacetrapib, a cholesterol ester transfer protein (CETP) inhibitor, has been reported to have longer elimination half-life after longer treatment. Two pharmacokinetic model-based approaches were used to assess whether evacetrapib, another CETP inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de10d9a7ddf9d57b1ec1982284c5681f
https://doi.org/10.1002/jcph.472
https://doi.org/10.1002/jcph.472
Autor:
Sohail Rana, Kenneth J. Winters, Julie Kanter, Darell Heiselman, Joseph A. Jakubowski, Rupa Redding-Lallinger, Brian A. Moser, Charles T. Quinn, Matthew M. Heeney, Lori E. Heath, Lori Styles, Chunmei Zhou, David S. Small
Publikováno v:
Journal of Pediatric Hematology/Oncology. 37:1-9
This phase 2 study was designed to characterize the relationship among prasugrel dose, prasugrel's active metabolite (Pras-AM), and platelet inhibition while evaluating safety in children with sickle cell disease. It was open-label, multicenter, adap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61e0c1d415ccbcdc56389bb7fb08fbb
https://doi.org/10.1097/mph.0000000000000291
https://doi.org/10.1097/mph.0000000000000291