Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David S Rueda"'
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011494 (2023)
Infections by Human T cell Leukaemia Virus type 1 (HTLV-1) persist for the lifetime of the host by integrating into the genome of CD4+ T cells. Proviral gene expression is essential for proviral survival and the maintenance of the proviral load, thro
Externí odkaz:
https://doaj.org/article/586772cf3450425d8cfabb05ba501696
Autor:
Michi Miura, Supravat Dey, Saumya Ramanayake, Abhyudai Singh, David S Rueda, Charles R M Bangham
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008164 (2019)
The human T cell leukemia virus HTLV-1 establishes a persistent infection in vivo in which the viral sense-strand transcription is usually silent at a given time in each cell. However, cellular stress responses trigger the reactivation of HTLV-1, ena
Externí odkaz:
https://doaj.org/article/8424ea5d518e46b796bd07217988a3a8
Infections by Human T cell Leukaemia Virus type 1 (HTLV-1) persist for the lifetime of the host by integrating into the genome of CD4+T cells. Proviral gene expression is core to proviral survival and the maintenance of the proviral load, through the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c223f7535e595f98c756bdbafc3f1bb
https://doi.org/10.1101/2023.01.08.523159
https://doi.org/10.1101/2023.01.08.523159
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2478
The discovery of CRISPR/Cas9 as an easily programmable endonuclease heralds a new era of genetic manipulation. With this comes the prospect of novel gene therapy approaches, and the potential to cure previously untreatable genetic diseases. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4a1f83e3d2ef0e25b55303e4987f0bc
https://pubmed.ncbi.nlm.nih.gov/36063327
https://pubmed.ncbi.nlm.nih.gov/36063327
Autor:
Matthew D. Newton, Marialucrezia Losito, Quentin Smith, Nishita Parnandi, Benjamin J. Taylor, Pinar Akcakaya, Marcello Maresca, Yi-Fang Wang, Simon J. Boulton, Graeme A. King, Maria Emanuela Cuomo, David S. Rueda
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13bb7f3e5d2f08c48491eef77c593599
https://doi.org/10.2139/ssrn.4199637
https://doi.org/10.2139/ssrn.4199637
Autor:
Artur P. Kaczmarczyk, Anne-Cécile Déclais, Matthew D. Newton, Simon J. Boulton, David M. J. Lilley, David S. Rueda
Resolution of Holliday junctions is a critical intermediate step of homologous recombination in which junctions are processed by junction-resolving endonucleases. Although binding and cleavage are well understood, the question remains how the enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2526e316cdc62f3f547f9de666bd5f2
Autor:
Roopesh Anand, Erika Buechelmaier, Ondrej Belan, Matthew Newton, Aleksandra Vancevska, Artur Kaczmarczyk, Tohru Takaki, David S. Rueda, Simon N. Powell, Simon J. Boulton
Publikováno v:
Nature
DNA double-stranded breaks (DSBs) are deleterious lesions, and their incorrect repair can drive cancer development1. HELQ is a superfamily 2 helicase with 3′ to 5′ polarity, and its disruption in mice confers germ cells loss, infertility and incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097ff54116635846b7903361da64aa48
Autor:
Ondrej Belan, Marie Sebald, Marek Adamowicz, Roopesh Anand, Aleksandra Vancevska, Joana Neves, Vera Grinkevich, Graeme Hewitt, Sandra Segura-Bayona, Roberto Bellelli, Helen M.R. Robinson, Geoff S. Higgins, Graeme C.M. Smith, Stephen C. West, David S. Rueda, Simon J. Boulton
Publikováno v:
Molecular Cell. 82:4664-4680.e9
POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is overexpressed in many cancers. POLQ inhibitors confer synthetic lethality in HR and Shieldin-deficient cancer cells, which has been proposed to reflect a critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0504a15f604a07e0bec33a46362c6602
https://doi.org/10.1016/j.molcel.2022.11.008
https://doi.org/10.1016/j.molcel.2022.11.008
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2404
In recent years, fluorogenic RNA aptamers, such as Spinach, Broccoli, Corn, Mango, Coral, and Pepper have gathered traction as an efficient alternative labeling strategy for background-free imaging of cellular RNAs. However, their application has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20405f0d1fe0b87a89784309ced3afa8
https://pubmed.ncbi.nlm.nih.gov/34694614
https://pubmed.ncbi.nlm.nih.gov/34694614
Autor:
Swathi Sudhakar, Gemma LM Fisher, Pilar Gutierrez-Escribano, Jonay Garcia-Luis, Christopher Cawood, Luis Aragon, David S Rueda
The authors have withdrawn this manuscript after detecting issues with two of the figures in the manuscript. Therefore, the authors do not wish this work to be cited as a reference. If you have any questions, please contact the corresponding authors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dacdc831797bb02bc40d5fe601131f71
https://doi.org/10.1101/2021.09.15.460217
https://doi.org/10.1101/2021.09.15.460217