Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David S Rogawski"'
Autor:
David S. Rogawski, Jing Deng, Hao Li, Hongzhi Miao, Dmitry Borkin, Trupta Purohit, Jiho Song, Jennifer Chase, Shuangjiang Li, Juliano Ndoj, Szymon Klossowski, EunGi Kim, Fengbiao Mao, Bo Zhou, James Ropa, Marta Z. Krotoska, Zhuang Jin, Patricia Ernst, Xiaomin Feng, Gang Huang, Kenichi Nishioka, Samantha Kelly, Miao He, Bo Wen, Duxin Sun, Andrew Muntean, Yali Dou, Ivan Maillard, Tomasz Cierpicki, Jolanta Grembecka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The histone methyltransferase ASH1L plays a role in various diseases, including cancer, and has been validated as a therapeutic target; however, no inhibitors of ASH1L have been reported. Here the authors present small molecule inhibitors of ASH1L an
Externí odkaz:
https://doaj.org/article/a51c519c90294569ac5da97219844f37
Autor:
Scott Horowitz, Brian Koepnick, Raoul Martin, Agnes Tymieniecki, Amanda A. Winburn, Seth Cooper, Jeff Flatten, David S. Rogawski, Nicole M. Koropatkin, Tsinatkeab T. Hailu, Neha Jain, Philipp Koldewey, Logan S. Ahlstrom, Matthew R. Chapman, Andrew P. Sikkema, Meredith A. Skiba, Finn P. Maloney, Felix R. M. Beinlich, Foldit Players, University of Michigan students, Zoran Popović, David Baker, Firas Khatib, James C. A. Bardwell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Building crystal structures into the electron density is an important step in protein structure solution. Here, the authors recruit online game players, students, and experienced crystallographers to compete in a competition to solve a new structure,
Externí odkaz:
https://doaj.org/article/b15fb233272548d7bc0404a5bf35e26f
Autor:
David S Rogawski, Jeffrey J Nirschl, Jamie McDonald, Esther Nie, Nicholas U Schwartz, Hannes Vogel, Brian J Scott, Carl A Gold, Lucas B Kipp
Publikováno v:
Mult Scler
Primary central nervous system (CNS) histiocytic sarcoma is a rare hematolymphoid malignancy with features of mature histiocytes and carries a poor prognosis. We describe a unique case in which a 50-year-old woman presented with recurrent acute brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd517f3032628e1b81174608d74f67a
https://europepmc.org/articles/PMC9942914/
https://europepmc.org/articles/PMC9942914/
Autor:
Sergei Zari, Juliano Ndoj, Jolanta Grembecka, Paula González-Alonso, Katarzyna Kempińska, Mykhaylo A. Potopnyk, Tomasz Cierpicki, Hongzhi Miao, Caroline Nikolaidis, Andrew D. Henderson, Huang Huang, Trupta Purohit, David S. Rogawski, Shirish Shukla, Christina A. Howard, Adolfo A. Ferrando, Hyo Je Cho, Joshua Abbott, Anna K. Mapp, Maria Luisa Sulis, Hao Li
Publikováno v:
Nature Chemical Biology. 16:1403-1410
The nuclear receptor-binding SET domain (NSD) family of histone methyltransferases is associated with various malignancies, including aggressive acute leukemia with NUP98-NSD1 translocation. While NSD proteins represent attractive drug targets, their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50ddaa9b49c0f149319c06274c09039
https://doi.org/10.1038/s41589-020-0626-6
https://doi.org/10.1038/s41589-020-0626-6
Autor:
Scott Horowitz, Brian Koepnick, Raoul Martin, Agnes Tymieniecki, Amanda A. Winburn, Seth Cooper, Jeff Flatten, David S. Rogawski, Nicole M. Koropatkin, Tsinatkeab T. Hailu, Neha Jain, Philipp Koldewey, Logan S. Ahlstrom, Matthew R. Chapman, Andrew P. Sikkema, Meredith A. Skiba, Finn P. Maloney, Felix R. M. Beinlich, Foldit Players, University of Michigan students, Zoran Popović, David Baker, Firas Khatib, James C. A. Bardwell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-2 (2016)
Nature Communications 7: Article number:12549 (2016); Published 16 September 2016; Updated 25 October 2016 The original version of this Article contained an error in the spelling of a member of the University of Michigan students Consortium, Sam Lee,
Externí odkaz:
https://doaj.org/article/1232003cb40a496181d47d61db72f8c2
Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase
Autor:
Ivan Maillard, Jolanta Grembecka, Juliano Ndoj, David S. Rogawski, Hyo Je Cho, Tomasz Cierpicki
Publikováno v:
Biochemistry. 54:5401-5413
ASH1L (absent, small, or homeotic-like 1) is a histone methyltransferase (HMTase) involved in gene activation that is overexpressed in multiple forms of cancer. Previous studies of ASH1L's catalytic SET domain identified an autoinhibitory loop that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad5906d6b3cd28454c2c03f3a5300d0
https://doi.org/10.1021/acs.biochem.5b00697
https://doi.org/10.1021/acs.biochem.5b00697
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 189
Malignant tumors of the central nervous system (CNS) cause substantial morbidity and mortality, yet efforts to optimize chemo- and radiotherapy have largely failed to improve dismal prognoses. Over the past decade, RNA sequencing (RNA-seq) has emerge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53409b0c206863305d034eea03cdddc
https://pubmed.ncbi.nlm.nih.gov/28746860
https://pubmed.ncbi.nlm.nih.gov/28746860