Výsledky vyhledávání - "David S Rogawski"

Akademický článek

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

The histone methyltransferase ASH1L plays a role in various diseases, including cancer, and has been validated as a therapeutic target; however, no inhibitors of ASH1L have been reported. Here the authors present small molecule inhibitors of ASH1L an

Externí odkaz: https://doaj.org/article/a51c519c90294569ac5da97219844f37

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Akademický článek

Determining crystal structures through crowdsourcing and coursework

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

Building crystal structures into the electron density is an important step in protein structure solution. Here, the authors recruit online game players, students, and experienced crystallographers to compete in a competition to solve a new structure,

Externí odkaz: https://doaj.org/article/b15fb233272548d7bc0404a5bf35e26f

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A rare neuromyelitis optica mimic: Primary CNS histiocytic sarcoma

Autor: David S Rogawski, Jeffrey J Nirschl, Jamie McDonald, Esther Nie, Nicholas U Schwartz, Hannes Vogel, Brian J Scott, Carl A Gold, Lucas B Kipp

Publikováno v: Mult Scler

Primary central nervous system (CNS) histiocytic sarcoma is a rare hematolymphoid malignancy with features of mature histiocytes and carries a poor prognosis. We describe a unique case in which a 50-year-old woman presented with recurrent acute brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd517f3032628e1b81174608d74f67a
https://europepmc.org/articles/PMC9942914/

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Covalent inhibition of NSD1 histone methyltransferase

Publikováno v: Nature Chemical Biology. 16:1403-1410

The nuclear receptor-binding SET domain (NSD) family of histone methyltransferases is associated with various malignancies, including aggressive acute leukemia with NUP98-NSD1 translocation. While NSD proteins represent attractive drug targets, their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50ddaa9b49c0f149319c06274c09039
https://doi.org/10.1038/s41589-020-0626-6

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Akademický článek

Correction: Corrigendum: Determining crystal structures through crowdsourcing and coursework

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-2 (2016)

Nature Communications 7: Article number:12549 (2016); Published 16 September 2016; Updated 25 October 2016 The original version of this Article contained an error in the spelling of a member of the University of Michigan students Consortium, Sam Lee,

Externí odkaz: https://doaj.org/article/1232003cb40a496181d47d61db72f8c2

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Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase

Autor: Ivan Maillard, Jolanta Grembecka, Juliano Ndoj, David S. Rogawski, Hyo Je Cho, Tomasz Cierpicki

Publikováno v: Biochemistry. 54:5401-5413

ASH1L (absent, small, or homeotic-like 1) is a histone methyltransferase (HMTase) involved in gene activation that is overexpressed in multiple forms of cancer. Previous studies of ASH1L's catalytic SET domain identified an autoinhibitory loop that b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad5906d6b3cd28454c2c03f3a5300d0
https://doi.org/10.1021/acs.biochem.5b00697

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Integrating RNA sequencing into neuro-oncology practice

Autor: Angela C. Gauthier, David S. Rogawski, Carl Koschmann, Vijay Ramaswamy, Nicholas A Vitanza

Publikováno v: Translational research : the journal of laboratory and clinical medicine. 189

Malignant tumors of the central nervous system (CNS) cause substantial morbidity and mortality, yet efforts to optimize chemo- and radiotherapy have largely failed to improve dismal prognoses. Over the past decade, RNA sequencing (RNA-seq) has emerge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53409b0c206863305d034eea03cdddc
https://pubmed.ncbi.nlm.nih.gov/28746860

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Akademický článek

A rare neuromyelitis optica mimic: Primary CNS histiocytic sarcoma.

Autor: Rogawski, David S, Nirschl, Jeffrey J, McDonald, Jamie, Nie, Esther, Schwartz, Nicholas U, Vogel, Hannes, Scott, Brian J, Gold, Carl A, Kipp, Lucas B

Publikováno v: Multiple Sclerosis Journal; Sep2022, Vol. 28 Issue 10, p1651-1654, 4p

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