Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David S Nelson"'
Autor:
David S Nelson, Ryan L Marano, Yechaan Joo, Sara Y Tian, Bhumi Patel, Daniel H Kaplan, Mark J Shlomchik, Kristen Stevenson, Roderick T Bronson, Barrett J Rollins
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222400 (2019)
Langerhans cell histiocytosis (LCH) is characterized by the accumulation of Langerin (CD207)-expressing histiocytes. Mutational activation of mitogen-activated protein kinase pathway genes, in particular BRAF, drives most cases. To test whether activ
Externí odkaz:
https://doaj.org/article/558463d275d0429ebb07e2d707219cea
Autor:
Kavindra Nath, Pradeep K. Gupta, Johnvesly Basappa, Shengchun Wang, Neil Sen, Cosimo Lobello, Jyoti S. Tomar, Alexander A. Shestov, Stepan Orlovskiy, Fernando Arias-Mendoza, Hilka Rauert-Wunderlich, David S. Nelson, Jerry D. Glickson, Mariusz A. Wasik
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Inhibition of kinases is the ever-expanding therapeutic approach to various types of cancer. Typically, assessment of the treatment response is accomplished by standard, volumetric imaging procedures, performed weeks to months aft
Externí odkaz:
https://doaj.org/article/0e7806c50fd74e3da89b30454ab92a58
Autor:
Kavindra Nath, David S Nelson, Mary E Putt, Dennis B Leeper, Bradley Garman, Katherine L Nathanson, Jerry D Glickson
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157125 (2016)
Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi r
Externí odkaz:
https://doaj.org/article/edabb1cb976542708485b2c13e2ae9d4
Autor:
Pradeep Kumar Gupta, Stepan Orlovskiy, Fernando Arias-Mendoza, David S. Nelson, Kavindra Nath
Publikováno v:
Cells, Vol 13, Iss 14, p 1220 (2024)
The MAPK signaling pathway with BRAF mutations has been shown to drive the pathogenesis of 40–60% of melanomas. Inhibitors of this pathway’s BRAF and MEK components are currently used to treat these malignancies. However, responses to these treat
Externí odkaz:
https://doaj.org/article/a659ad883c1c4462bc1a2a5317e66921
Publikováno v:
NMR in Biomedicine. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e9ceff8d03bb5180e8dbc23aaa4a5d5
https://doi.org/10.1002/nbm.4716
https://doi.org/10.1002/nbm.4716
Autor:
Willemijn T. Quispel, Gayane Badalian-Very, David S. Nelson, Laura E. MacConaill, Barrett J. Rollins, Astrid G. S. van Halteren, Judith V.M.G. Bovée, R. Maarten Egeler, Cor van den Bos, Bhumi Patel, Paul Van Hummelen, Matthew D. Ducar, Ling Lin
Publikováno v:
Genes, chromosomes & cancer, 54(6), 361-368. Wiley-Liss Inc.
Genes, Chromosomes and Cancer, 54(6), 361-368
Genes, Chromosomes and Cancer, 54(6), 361-368
Langerhans cell histiocytosis (LCH) is now understood to be a neoplastic disease in which over 50% of cases have somatic activating mutations of BRAF. However, the extracellular signal-related (ERK) pathway is activated in all cases including those w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1827e6d90fb7c298d765195bbbf7e092
https://doi.org/10.1002/gcc.22247
https://doi.org/10.1002/gcc.22247
Autor:
Yechaan Joo, Bhumi Patel, Daniel H. Kaplan, David S. Nelson, Barrett J. Rollins, Roderick T. Bronson, Kristen E. Stevenson, Mark J. Shlomchik, Ryan L. Marano, Sara Y. Tian
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 9, p e0222400 (2019)
PLoS ONE, Vol 14, Iss 9, p e0222400 (2019)
Langerhans cell histiocytosis (LCH) is characterized by the accumulation of Langerin (CD207)-expressing histiocytes. Mutational activation of mitogen-activated protein kinase pathway genes, in particular BRAF, drives most cases. To test whether activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13ee5a6fc272092de8121b3fff8668a
https://doi.org/10.1371/journal.pone.0222400
https://doi.org/10.1371/journal.pone.0222400
Autor:
David S. Nelson
Publikováno v:
Educational Measurement: Issues and Practice. 13:29-35
How might empirical j o b analysis give the appearance of science to a flawed public policy? How do “political” factors have an impact on the development of licensure tests? What are areas for future research and for improvement of prevailing pra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e251d03873d975683aa4c33cb0511b88
https://doi.org/10.1111/j.1745-3992.1994.tb00447.x
https://doi.org/10.1111/j.1745-3992.1994.tb00447.x
Autor:
Gayane Badalian-Very, Judith V.M.G. Bovée, David S. Nelson, Paul Van Hummelen, R. Maarten Egeler, Sara Y. Tian, Cor van den Bos, Laura E. MacConaill, Barrett J. Rollins, Matthew D. Ducar, Astrid G. S. van Halteren, Willemijn T. Quispel
Publikováno v:
Blood, 123(20), 3152-3155
Blood, 123(20), 3152-3155. American Society of Hematology
Blood, 123(20), 3152-3155. American Society of Hematology
The extracellular signal-regulated kinase (ERK) signaling pathway is activated in Langerhans cell histiocytosis (LCH) histiocytes, but only 60% of cases carry somatic activating mutations of BRAF. To identify other genetic causes of ERK pathway activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503febba8767eeb45e54d322eb38d79a
https://hdl.handle.net/1887/103873
https://hdl.handle.net/1887/103873
Autor:
Elizabeth Sztul, Rafael Garcia-Mata, Adam D. Linstedt, Stephen A. Jesch, David S. Nelson, Amy J. Mehta, Tina H. Lee
Publikováno v:
Journal of Biological Chemistry. 275:10196-10201
By forming a molecular tether between two membranes, p115, giantin, and GM130 may mediate multiple Golgi-related processes including vesicle transport, cisternae formation, and cisternal stacking. The tether is proposed to involve the simultaneous bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::957b84337b272eb5dd39b1bb68ba9521
https://doi.org/10.1074/jbc.275.14.10196
https://doi.org/10.1074/jbc.275.14.10196