Zobrazeno 1 - 10
of 67
pro vyhledávání: '"David S Moura"'
Autor:
Andrés Redondo, Joaquin Dopazo, José A López-Martin, Nadia Hindi, Javier Martin-Broto, Silvia Stacchiotti, Giovanni Grignani, Claudia Valverde, Paola Collini, Javier Martinez-Trufero, Antonio Lopez-Pousa, Lorenzo D'Ambrosio, Antonio Gutierrez, Herminia Perez-Vega, Victor Encinas-Tobajas, Enrique de Alava, Maria Peña-Chilet, Irene Carrasco-Garcia, Maria Lopez-Alvarez, David S Moura
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity of PD-1 inhibitors. A potential strategy to convert a cold into an inflamed microenvironment lies on a combination therapy. As t
Externí odkaz:
https://doaj.org/article/ba0c92285ab347e788e84cf5c6815dde
Autor:
José L. Mondaza-Hernandez, Nadia Hindi, Antonio Fernandez-Serra, Rafael Ramos, Ricardo Gonzalez-Cámpora, María Carmen Gómez-Mateo, Javier Martinez-Trufero, Javier Lavernia, Antonio Lopez-Pousa, Nuria Laínez, Jeronimo Martinez-Garcia, Claudia Valverde, María Ángeles Vaz-Salgado, Gabriel Garcia-Plaza, Isabel Marin-Borrero, Jaime Carrillo-Garcia, Marta Martin-Ruiz, Pablo Romero, Antonio Gutierrez, Jose A. López-Guerrero, David S. Moura, Javier Martin-Broto
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Alveolar soft-part sarcoma (ASPS) is a rare tumor driven by the ASPSCR1-TFE3 fusion protein, with a propensity for metastasis. Prognostic factors remain poorly understood, and traditional chemotherapies are largely ineffective. Recent int
Externí odkaz:
https://doaj.org/article/a6bb78ace54b4bffac308c6bcc6f7d85
Autor:
Yi Li, Jose L. Mondaza-Hernandez, David S. Moura, Alexey S. Revenko, Angelica Tolentino, John T. Nguyen, Nam Tran, Clark A. Meyer, Jose Merino-Garcia, Rafael Ramos, Davide Di Lernia, Javier Martin-Broto, Heather N. Hayenga, Leonidas Bleris
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102154- (2024)
Solitary fibrous tumor (SFT) is a rare, non-hereditary soft tissue sarcoma thought to originate from fibroblastic mesenchymal stem cells. The etiology of SFT is thought to be due to an environmental intrachromosomal gene fusion between NGFI-A-binding
Externí odkaz:
https://doaj.org/article/5d8f5d5b1be74d249583ba786160cba2
Autor:
Javier Martin-Broto, Jeronimo Martinez-Garcia, David S. Moura, Andres Redondo, Antonio Gutierrez, Antonio Lopez-Pousa, Javier Martinez-Trufero, Isabel Sevilla, Roberto Diaz-Beveridge, Maria Pilar Solis-Hernandez, Amancio Carnero, Marco Perez, David Marcilla, Jesus Garcia-Foncillas, Pablo Romero, Javier Fernandez-Jara, Daniel Lopez-Lopez, Ivan Arribas, Nadia Hindi
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more c
Externí odkaz:
https://doaj.org/article/0c66d90901d244e6922dd1f9ea0a3f1f
Autor:
Javier Martin-Broto, Claudia Valverde, Nadia Hindi, Bruno Vincenzi, Javier Martinez-Trufero, Giovanni Grignani, Antoine Italiano, Javier Lavernia, Ana Vallejo, Paolo Dei Tos, Francois Le Loarer, Ricardo Gonzalez-Campora, Rafael Ramos, Diana Hernández-Jover, Antonio Gutierrez, Cesar Serrano, Maria Monteagudo, Rocio Letón, Mercedes Robledo, David S. Moura, Marta Martin-Ruiz, Jose A. López-Guerrero, Julia Cruz, Antonio Fernandez-Serra, Jean-Yves Blay, Elena Fumagalli, Virginia Martinez-Marin
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-8 (2023)
Abstract Background Approximately 15% of adult GIST patients harbor tumors that are wild-type for KIT and PDGFRα genes (KP-wtGIST). These tumors usually have SDH deficiencies, exhibit a more indolent behavior and are resistant to imatinib. Underlyin
Externí odkaz:
https://doaj.org/article/da2ebd0056004ea28583248f6fd4476c
Autor:
Jaime Carrillo-García, Serena Lacerenza, Nadia Hindi, Irene Carrasco García, Gloria Marquina, Juana María Cano Cano, Javier Martínez Trufero, Alberto Rafael Sevillano Tripero, Tania Luis García, Manuel Jorge Cuesta Rioboo, David S. Moura, Marta Renshaw, Jose L. Mondaza-Hernández, Davide Di Lernia, Antonio Gutierrez, Javier Martin-Broto
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background and objectives: Social distancing and quarantine implanted during the COVID-19 outbreak could have delayed the accession of oncologic patients to hospitals and treatments. This study analysed the management of sarcoma patients during this
Externí odkaz:
https://doaj.org/article/4176abcd3fc94b44bd8251892b02ec4b
Autor:
Javier Martin-Broto, Alicia Olarte-García, Ricardo Fernandéz-Rodríguez, Marta Ribeiro Ferreira, Irene Carrasco-García, Fernando Galvez-Montosa, Inmaculada Rincon-Perez, Javier Peinado-Serrano, Ignacio Azinovic, Laura Guzman-Gomez, Lurdes Salgado, Alberto Sevillano, Justo Ortega, Cristina Alvarez, Antonio Gutierrez, David S. Moura, Nadia Hindi
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background and objectives: Dimensional response is an unmet need in second lines of advanced soft tissue sarcomas (STS). Indeed, the three approved drugs, pazopanib, trabectedin, and eribulin, achieved an overall response rate (ORR) of less than 10%.
Externí odkaz:
https://doaj.org/article/1475ef79f82c4873859ed0806a878ff3
Autor:
Bleris, Yi Li, John T. Nguyen, Manasvini Ammanamanchi, Zikun Zhou, Elijah F. Harbut, Jose L. Mondaza-Hernandez, Clark A. Meyer, David S. Moura, Javier Martin-Broto, Heather N. Hayenga, Leonidas
Publikováno v:
Cancers; Volume 15; Issue 12; Pages: 3127
Solitary fibrous tumor (SFT) is a rare soft-tissue sarcoma. This nonhereditary cancer is the result of an environmental intrachromosomal gene fusion between NAB2 and STAT6 on chromosome 12, which fuses the activation domain of STAT6 with the repressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::831f38d1201715c5e215dcba3bb53104
Autor:
Alessandro Gronchi, Paolo G. Casali, Piero Picci, Angelo Paolo Dei Tos, Nadia Hindi, Claudia Valverde, Antonio Gutierrez, Antonella Brunello, Jean-Yves Blay, Giovanni Grignani, Antonio Lopez-Pousa, Vittorio L. Quagliuolo, Silvia Stacchiotti, Emanuela Palmerini, Domenico Franco Merlo, Luca Braglia, Marco Gambarotti, Joaquin Dopazo, Daniel Lopez-Lopez, Jean-Michel Coindre, Valerie Velasco, Marta Barisella, Salvatore L. Renne, Silvia Bagué, Cleofe Romagosa, Paola Collini, Rafael Ramos, David S. Moura, Maria Lopez-Alvarez, Javier Martin-Broto
Supplementary Figures (From S1 to S10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebaede9a37e6367942a402831369f08
https://doi.org/10.1158/1535-7163.22522905.v1
https://doi.org/10.1158/1535-7163.22522905.v1
Autor:
Alessandro Gronchi, Paolo G. Casali, Piero Picci, Angelo Paolo Dei Tos, Nadia Hindi, Claudia Valverde, Antonio Gutierrez, Antonella Brunello, Jean-Yves Blay, Giovanni Grignani, Antonio Lopez-Pousa, Vittorio L. Quagliuolo, Silvia Stacchiotti, Emanuela Palmerini, Domenico Franco Merlo, Luca Braglia, Marco Gambarotti, Joaquin Dopazo, Daniel Lopez-Lopez, Jean-Michel Coindre, Valerie Velasco, Marta Barisella, Salvatore L. Renne, Silvia Bagué, Cleofe Romagosa, Paola Collini, Rafael Ramos, David S. Moura, Maria Lopez-Alvarez, Javier Martin-Broto
Supplementary Table S4 - Affinity energies of nilotinib and avapritinib for the different structures of MRP-1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fcabbb9fa5e7a9c881a50f56a200c06
https://doi.org/10.1158/1535-7163.22522890
https://doi.org/10.1158/1535-7163.22522890