Zobrazeno 1 - 10 of 133 pro vyhledávání: '"David S Larsen"'
1
Akademický článek
Bridging Small Molecules to Modified Bacterial Microparticles Using a Disulphide Linkage: MIS416 as a Cargo Delivery System.
Autor: Francesco Mainini, David S Larsen, Gill A Webster, Sarah L Young, Michael R Eccles
Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145403 (2015)
MIS416 is an intact minimal cell wall skeleton derived from Proprionibacterium acnes that is phagocytosed by antigen presenting cells, including dendritic cells (DCs). This property allows MIS416 to be exploited as a vehicle for the delivery of pepti
Externí odkaz: https://doaj.org/article/6a2ad67ba73d431ca5982472ae3be047
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2
Akademický článek
Mannosylation of virus-like particles enhances internalization by antigen presenting cells.
Autor: Farah Al-Barwani, Sarah L Young, Margaret A Baird, David S Larsen, Vernon K Ward
Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104523 (2014)
Internalization of peptides by antigen presenting cells is crucial for the initiation of the adaptive immune response. Mannosylation has been demonstrated to enhance antigen uptake through mannose receptors, leading to improved immune responses. In t
Externí odkaz: https://doaj.org/article/c6ab83fe967b4facbd14d1c30ae5b716
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3
Akademický článek
The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament
Autor: Fergus M. Payne, Samantha Nie, Gary M. Diffee, Gerard T. Wilkins, David S. Larsen, Joanne C. Harrison, James C. Baldi, Ivan A. Sammut
Publikováno v: Physiological Reports, Vol 12, Iss 6, Pp n/a-n/a (2024)
Abstract Patients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved inotropes with
Externí odkaz: https://doaj.org/article/e44a89140be34264b3c3104a075603b8
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4
Akademický článek
Chemical Synthesis of the PAX Protein Inhibitor EG1 and Its Ability to Slow the Growth of Human Colorectal Carcinoma Cells
Autor: Lorissa McDougall, Jui Thiang Brian Kueh, Jake Ward, Joel D. A. Tyndall, Adele G. Woolley, Sunali Mehta, Cherie Stayner, David S. Larsen, Michael R. Eccles
Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Colorectal cancer is primarily a disease of the developed world. The incidence rate has continued to increase over time, reflecting both demographic and lifestyle changes, which have resulted in genomic and epigenomic modifications. Many of the epige
Externí odkaz: https://doaj.org/article/7c0470994dd64154b474f501a830dc33
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5
Akademický článek
Functionalisation of Virus-Like Particles Enhances Antitumour Immune Responses
Autor: Katrin Kramer, Farah Al-Barwani, Margaret A. Baird, Vivienne L. Young, David S. Larsen, Vernon K. Ward, Sarah L. Young
Publikováno v: Journal of Immunology Research, Vol 2019 (2019)
Virus-like particles (VLP) from the rabbit haemorrhagic disease virus (RHDV) can deliver tumour antigens to induce anticancer immune responses. In this study, we explored how RHDV VLP can be functionalised to enhance the immune response by increasing
Externí odkaz: https://doaj.org/article/0882ebfbf55a4ce38ae4777e914b9228
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7
2-O-β-d-Glucopyranosyl l-Ascorbic Acid, a Stable Form of Vitamin C, Is Widespread in Crop Plants
Autor: William A. Laing, Tony K. McGhie, Sarah Cordiner, Teiarere T. H. Stephens, Nigel B. Perry, David S. Larsen, Alistair T. B. Richardson
Publikováno v: Journal of Agricultural and Food Chemistry. 69:966-973
2-O-β-d-Glucopyranosyl l-ascorbic acid (AA-2βG) is a stable, bioavailable vitamin C (AA) derivative. We report the distribution and seasonal variation of AA-2βG in apples and its occurrence in other domesticated crops and in wild harvested Ma̅ori
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a01c968f342cee0b64f8f0311c173f
https://doi.org/10.1021/acs.jafc.0c06330
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9
Synthetic preparation and immunological evaluation of β-mannosylceramide and related N-acyl analogues
Autor: Sage A. Robinson, Gavin F. Painter, Benjamin J. Compton, Masaki Terabe, Jessica Yau, David S. Larsen, Jay A. Berzofsky
Publikováno v: Org Biomol Chem
The synthesis of the invariant natural killer (iNK) T cell agonist β-mannosylceramide along with a series of fatty amide analogues is reported. Of the six β-glycosylation protocols investigated, the sulfoxide methodology developed by Crich and co-w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23b5b337d0e80e3d0c8de9b77ee4b16
https://doi.org/10.1039/d0ob00223b
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10
MIS416 as a siRNA Delivery System with the Ability to Target Antigen-Presenting Cells
Autor: Michael R. Eccles, Francesco Mainini, Gill A. Webster, David S. Larsen, Sarah L. Young
Publikováno v: Nucleic Acid Therapeutics
MIS416 is a microparticulate formulation derived from propionibacterium acnes cell wall skeletons with intrinsic adjuvant activity. Conjugates of MIS416-SS-peptide containing a disulfide linkage facilitate the cytoplasmic delivery and release of pept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c314fed785cd2bff207b0f034326761
https://doi.org/10.1089/nat.2017.0695
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