Zobrazeno 1 - 10
of 100
pro vyhledávání: '"David S Guttery"'
Autor:
Konstantinos Polymeros, David S Guttery, Roger Hew, Rachael Bishop, Elizabeth Stannard, Salvador Macip, Paul Symonds, Esther L Moss
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233900 (2020)
ObjectivesTo identify differences in the mutational profile of endometrial tumours between British White (BW) and South Asian (BSA) women.MethodsWe analysed primary tumours from matched cohorts of British White (BW) and British South Asian (BSA) wome
Externí odkaz:
https://doaj.org/article/734ecce134644f18a7a33e329bd4102a
Autor:
Magali Roques, Richard J Wall, Alexander P Douglass, Abhinay Ramaprasad, David J P Ferguson, Mbinda L Kaindama, Lorenzo Brusini, Nimitray Joshi, Zineb Rchiad, Declan Brady, David S Guttery, Sally P Wheatley, Hiroyuki Yamano, Anthony A Holder, Arnab Pain, Bill Wickstead, Rita Tewari
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005273 (2015)
Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisi
Externí odkaz:
https://doaj.org/article/9d00b0910463472693797595a9f28ce8
Autor:
Kevin Blighe, Laura Kenny, Naina Patel, David S Guttery, Karen Page, Julian H Gronau, Cyrus Golshani, Justin Stebbing, R Charles Coombes, Jacqueline A Shaw
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115346 (2014)
BACKGROUND:Intratumoral heterogeneity may help drive resistance to targeted therapies in cancer. In breast cancer, the presence of nodal metastases is a key indicator of poorer overall survival. The aim of this study was to identify somatic genetic a
Externí odkaz:
https://doaj.org/article/359cd41639f74ebf893bed745b8607f0
Autor:
David S Guttery, Jon K Pittman, Karine Frénal, Benoit Poulin, Leon R McFarlane, Ksenija Slavic, Sally P Wheatley, Dominique Soldati-Favre, Sanjeev Krishna, Rita Tewari, Henry M Staines
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003191 (2013)
Ca(2+) contributes to a myriad of important cellular processes in all organisms, including the apicomplexans, Plasmodium and Toxoplasma. Due to its varied and essential roles, free Ca(2+) is tightly regulated by complex mechanisms. These mechanisms a
Externí odkaz:
https://doaj.org/article/42f3160f14564641b9f8988cfc23cef0
Autor:
Karen Page, David S Guttery, Nathalie Zahra, Lindsay Primrose, Shona R Elshaw, J Howard Pringle, Kevin Blighe, Stephanie D Marchese, Allison Hills, Laura Woodley, Justin Stebbing, R Charles Coombes, Jacqueline A Shaw
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77963 (2013)
Circulating nucleic acids (CNAs) are under investigation as a liquid biopsy in cancer. However there is wide variation in blood processing and methods for isolation of circulating free DNA (cfDNA) and microRNAs (miRNAs). Here we compare the extractio
Externí odkaz:
https://doaj.org/article/944c8282c5394da3b6e8e053a06c57e6
Autor:
David S Guttery, Benoit Poulin, David J P Ferguson, Balázs Szöőr, Bill Wickstead, Paula L Carroll, Chandra Ramakrishnan, Declan Brady, Eva-Maria Patzewitz, Ursula Straschil, Lev Solyakov, Judith L Green, Robert E Sinden, Andrew B Tobin, Anthony A Holder, Rita Tewari
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002948 (2012)
Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways, and are often deregulated in a number of pathological
Externí odkaz:
https://doaj.org/article/787f86477eb34663a6cbe46eb8a005ed
A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.
Autor:
David S Guttery, David J P Ferguson, Benoit Poulin, Zhengyao Xu, Ursula Straschil, Onny Klop, Lev Solyakov, Sara M Sandrini, Declan Brady, Conrad A Nieduszynski, Chris J Janse, Anthony A Holder, Andrew B Tobin, Rita Tewari
Publikováno v:
PLoS Pathogens, Vol 8, Iss 2, p e1002554 (2012)
Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC
Externí odkaz:
https://doaj.org/article/afaf2384a3fa4287927c04594b077351
Publikováno v:
PLoS Pathogens, Vol 8, Iss 1, p e1002404 (2012)
Externí odkaz:
https://doaj.org/article/41552250f9e4420b9ed1b3a043eabc80
Autor:
Mohammad Zeeshan, Edward Rea, Steven Abel, Kruno Vukušić, Robert Markus, Declan Brady, Antonius Eze, Ravish Rashpa, Aurelia C. Balestra, Andrew R. Bottrill, Mathieu Brochet, David S. Guttery, Iva M. Tolić, Anthony A. Holder, Karine G. Le Roch, Eelco C. Tromer, Rita Tewari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein scaffolds. Plasmodium spp., the causative agents of
Externí odkaz:
https://doaj.org/article/b48dddf02dd94fbda52d44cd32baa0e1
Autor:
Christopher S. Trethewey, Harriet S. Walter, Abdullah N. M. Alqahtani, Ralf Schmid, David S. Guttery, Yvette Griffin, Matthew J. Ahearne, Gerald S. Saldanha, Sandrine P. N. Jayne, Martin J. S. Dyer
Publikováno v:
HemaSphere, Vol 6, Iss 3, p e690 (2022)
Externí odkaz:
https://doaj.org/article/967ccda3ab2f4e9ab9d08f2e07306d19