Zobrazeno 1 - 10
of 213
pro vyhledávání: '"David S Cafiso"'
Autor:
Sarah B. Nyenhuis, Nakul Karandikar, Volker Kiessling, Alex J. B. Kreutzberger, Anusa Thapa, Binyong Liang, Lukas K. Tamm, David S. Cafiso
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Synaptotagmin 1 (Syt1) is the calcium sensor for fast synchronous neurotransmitter release but the mechanism by which it functions is still under debate. Here, the authors combine EPR measurements and functional studies and observe that different fac
Externí odkaz:
https://doaj.org/article/81777fc5abd14f21a6ee0ae5308e9f0f
Publikováno v:
eLife, Vol 10 (2021)
Outer membrane TonB-dependent transporters facilitate the uptake of trace nutrients and carbohydrates in Gram-negative bacteria and are essential for pathogenic bacteria and the health of the microbiome. Despite this, their mechanism of transport is
Externí odkaz:
https://doaj.org/article/872728cdf3f14e5da5725acea389fa85
Publikováno v:
Biophysical Journal. 122:515a-516a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77bf9707553ca1972e71a9771f7cbb2f
https://doi.org/10.1016/j.bpj.2022.11.2742
https://doi.org/10.1016/j.bpj.2022.11.2742
Autor:
Marcin D Roganowicz, Sevnur Komurlu, Santanu Mukherjee, Jacek Plewka, Steven L Alam, Katarzyna A Skorupka, Yueping Wan, Damian Dawidowski, David S Cafiso, Barbie K Ganser-Pornillos, Edward M Campbell, Owen Pornillos
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006686 (2017)
Restriction factors are important components of intrinsic cellular defense mechanisms against viral pathogens. TRIM5α is a restriction factor that intercepts the incoming capsid cores of retroviruses such as HIV and provides an effective species-spe
Externí odkaz:
https://doaj.org/article/df135015d24340ad92100211730e0580
Autor:
Qian, Liang, Akosua P, Ofosuhene, Volker, Kiessling, Binyong, Liang, Alex J B, Kreutzberger, Lukas K, Tamm, David S, Cafiso
Publikováno v:
Biophysical journal. 121(18)
Complexin-1 is an essential protein for neuronal exocytosis that acts to depress spontaneous fusion events while enhancing evoked neurotransmitter release. In addition to binding soluble N-ethylmaleimide-sensitive factor attachment protein receptors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2cf6d91ba39320a44a5399e88e5ae95
https://pubmed.ncbi.nlm.nih.gov/36016497
https://pubmed.ncbi.nlm.nih.gov/36016497
Autor:
Ángel Pérez-Lara, Anusa Thapa, Sarah B Nyenhuis, David A Nyenhuis, Partho Halder, Michael Tietzel, Kai Tittmann, David S Cafiso, Reinhard Jahn
Publikováno v:
eLife, Vol 5 (2016)
The Ca2+-sensor synaptotagmin-1 that triggers neuronal exocytosis binds to negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIns)) but the molecular details of this process are not fully understood. Usin
Externí odkaz:
https://doaj.org/article/c02207f7628d429d958a8be352713cec
Autor:
Katja Barth, Benesh Joseph, Arthur Sikora, David S. Cafiso, Thomas F. Prisner, Eva A. Jaumann
Publikováno v:
Nature protocols
Observing structure and conformational dynamics of membrane proteins at high-resolution in their native environments is challenging because of the lack of suitable techniques. We have developed an approach for high-precision distance measurements in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09f67b4f5c223bf24232a7fd7cba688
https://doi.org/10.1038/s41596-019-0182-2
https://doi.org/10.1038/s41596-019-0182-2
Publikováno v:
Biophys J
Synaptotagmin 1 acts as the Ca2+-sensor for synchronous neurotransmitter release; however, the mechanism by which it functions is not understood and is presently a topic of considerable interest. Here we describe measurements on full-length membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d168fae2faf3f90c2b056936a447d343
https://doi.org/10.1016/j.bpj.2019.06.016
https://doi.org/10.1016/j.bpj.2019.06.016
Publikováno v:
J Phys Chem Lett
Multistructured biomolecular systems play crucial roles in a wide variety of cellular processes but have resisted traditional methods of structure determination, which often resolve only a few low-energy states. High-resolution structure determinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b9a71f55686bcdda97bb8895b669a0
https://doi.org/10.1021/acs.jpclett.9b01407
https://doi.org/10.1021/acs.jpclett.9b01407