Zobrazeno 1 - 10
of 231
pro vyhledávání: '"David S Bredt"'
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53965 (2013)
Postsynatptic density protein (PSD-95) is a 95 kDa scaffolding protein that assembles signaling complexes at synapses. Over-expression of PSD-95 in primary hippocampal neurons selectively increases synaptic localization of AMPA receptors; however, mi
Externí odkaz:
https://doaj.org/article/cb0fdc4282714bdbb3186b1660ffe58a
Autor:
Jose A. Matta, Shenyan Gu, Weston B. Davini, Brian Lord, Edward R. Siuda, Anthony W. Harrington, David S. Bredt
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 688-696 (2017)
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine. Neuronal nAChRs derive from combinations of α and β subunits, whose assembly is tightl
Externí odkaz:
https://doaj.org/article/3133717f13e440569d759f9048cbb811
Publikováno v:
Science (New York, N.Y.). 373(6556)
The neurotransmitter acetylcholine (ACh) acts in part through a family of nicotinic ACh receptors (nAChRs), which mediate diverse physiological processes including muscle contraction, neurotransmission, and sensory transduction. Pharmacologically, nA
Autor:
Paul L. Ornstein, David S. Bredt, Vanessa N. Barth, Eric S. Nisenbaum, Kar-Chan Choong, Wenhong Guo, Warren J. Porter, Kevin Matthew Gardinier, Emanuele Sher, Yue-Wei Qian, Jon K. Reel, Christian C. Felder, John T. Catlow, Rosa Maria A. Simmons, Kevin D. Burris, Kelly L. Knopp, Douglas Linn Gernert, Chunjin Ding, Steven Swanson, Anne B. Need, Theron M. Wall, He Wang, Akihiko Kato, Douglas A. Schober, Ruud Zwart, Benjamin L. Adams, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:345-363
Nonselective glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists are efficacious in chronic pain but have significant tolerability issues, likely arising from the ubiquitous expression of AMPA receptors in the
Autor:
Kristian Strømgaard, Bernhard Bettler, Louise S. Clemmensen, David S. Bredt, Mette Ishøy Rosenbaum
Publikováno v:
Nature reviews. Drug discovery. 19(12)
Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled receptors, has directly enabled the discovery of most drugs developed to modulate receptor signalling. However, as the search for novel and improved drugs continues,
Autor:
David S. Bredt, Jose A. Matta, Hae-Jin Kweon, Madhurima Dhara, Weston B. Davini, Daniel Knowland, Min Lei O'carroll, Shenyan Gu
Publikováno v:
Proc Natl Acad Sci U S A
Auditory hair cells receive olivocochlear efferent innervation, which refines tonotopic mapping, improves sound discrimination, and mitigates acoustic trauma. The olivocochlear synapse involves α9α10 nicotinic acetylcholine receptors (nAChRs), whic
Autor:
Hae-Jin Kweon, Elodie Desuzinges Mandon, Madhurima Dhara, Anass Jawhari, David S. Bredt, Hong Yu, Shenyan Gu, Emily Witham
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108025-(2020)
Summary: The α7 nicotinic acetylcholine receptor participates in diverse aspects of brain physiology and disease. Neurons tightly control α7 assembly, which relies upon NACHO, an endoplasmic reticulum (ER)-localized integral membrane protein. By co
Autor:
Min Lei, Madhurima Dhara, Hong Yu, Shenyan Gu, Jose A. Matta, Daniel Knowland, David S. Bredt
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Small molecule polyamines are abundant in all life forms and participate in diverse aspects of cell growth and differentiation. Spermidine/spermine acetyltransferase (SAT1) is the rate-limiting enzyme in polyamine catabolism and a primary genetic ris
Autor:
James Limberis, Daniel Knowland, Anindya Bhattacharya, William A. Eckert, Alan D. Wickenden, Shenyan Gu, David S. Bredt, Jose A. Matta, G. Brent Dawe
Publikováno v:
J Clin Invest
The α6β4 nicotinic acetylcholine receptor (nAChR) is enriched in dorsal root ganglia neurons and is an attractive non-opioid therapeutic target for pain. However, difficulty expressing human α6β4 receptors in recombinant systems has precluded dru
Autor:
David M. Holtzman, Joshua Kilbridge, David S. Bredt, Stephen M. Black, Yiwen Li, Douglas O. Clary, Louis F. Reichardt, William C. Mobley
Publikováno v:
Neurobiology of Disease, Vol 1, Iss 1, Pp 51-60 (1994)
Nerve growth factor (NGF) acts through trkA receptors to serve as a trophic factor for cholinergic neurones in the medial septal nucleus (MSN) and vertical limb of the diagonal band (VDB). Herein, we show that brain nitric oxide synthase (NOS), which
Externí odkaz:
https://doaj.org/article/639ba83e32fe427cbed0d0ffc407c365