Zobrazeno 1 - 10
of 325
pro vyhledávání: '"David S, Schrump"'
Autor:
Anand Singh, Nathanael Pruett, Shivani Dixit, Sudheer K. Gara, Haitao Wang, Roma Pahwa, David S. Schrump, Chuong D. Hoang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background Diffuse pleural mesothelioma (DPM) is an aggressive therapy-resistant cancer with unique molecular features. Numerous agents have been tested, but clinically effective ones remain elusive. Herein, we propose to use a small molecul
Externí odkaz:
https://doaj.org/article/22fc4d3729de4ebd8279bd47b42e0c46
Autor:
Shingo Inaguma, Akane Ueki, Jerzy Lasota, Masayuki Komura, Asraful Nahar Sheema, Piotr Czapiewski, Renata Langfort, Janusz Rys, Joanna Szpor, Piotr Waloszczyk, Krzysztof Okoń, Wojciech Biernat, David S Schrump, Raffit Hassan, Markku Miettinen, Satoru Takahashi
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 3, Pp 195-207 (2023)
Abstract Diffuse pleural mesothelioma (PM) is a highly aggressive tumour typically associated with short survival. Recently, the effectiveness of first‐line immune checkpoint inhibitors in patients with unresectable PM was reported. CD70–CD27 sig
Externí odkaz:
https://doaj.org/article/6d4e4c48d948460d99cc49262b4cd222
Autor:
Zuoxiang Xiao, Gongping Shi, Sichuan Xi, Amit Kumar Singh, Jami Willette-Brown, Xin Li, Feng Zhu, Ling Su, Xiaolin Wu, David S. Schrump, Yinling Hu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-14 (2022)
Abstract Tumor necrosis factor receptor 1 (TNFR1), encoded by TNFRSF1A, is a critical transducer of inflammatory pathways, but its physiological role in human cancer is not completely understood. Here, we observed high expression of TNFR1 in many hum
Externí odkaz:
https://doaj.org/article/8520799e14f04d40aa2b525c9da226f5
Autor:
Sudipta Biswas, Kai Kang, Kwok Peng Ng, Tomas Radivoyevitch, Kurt Schalper, Hua Zhang, Daniel J. Lindner, Anish Thomas, David MacPherson, Brian Gastman, David S. Schrump, Kwok-Kin Wong, Vamsidhar Velcheti, Yogen Saunthararajah
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 113016- (2023)
Summary: Small cell lung cancers (SCLCs) rapidly resist cytotoxic chemotherapy and immune checkpoint inhibitor (ICI) treatments. New, non-cross-resistant therapies are thus needed. SCLC cells are committed into neuroendocrine lineage then maturation
Externí odkaz:
https://doaj.org/article/6e798291ce2a49cb8119368cddc4ce46
Autor:
Anju Kumari, Lisa Gesumaria, Yan-Jin Liu, V. Keith Hughitt, Xiaohu Zhang, Michele Ceribelli, Kelli M. Wilson, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Craig J. Thomas, Beverly A. Mock, David S. Schrump, Haobin Chen
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Small cell lung cancer (SCLC) is a recalcitrant malignancy with limited treatment options. Bromodomain and extraterminal domain inhibitors (BETis) have shown promising preclinical activity in SCLC, but the broad sensitivity spectrum limits their clin
Externí odkaz:
https://doaj.org/article/486952269d6442e6887641df9fd39b64
Autor:
Kate Brown, Lisa M. Miller Jenkins, Daniel R. Crooks, Deborah R. Surman, Sharlyn J. Mazur, Yuan Xu, Bhargav S. Arimilli, Ye Yang, Andrew N. Lane, Teresa W-M. Fan, David S. Schrump, W. Marston Linehan, R. Taylor Ripley, Ettore Appella
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
TP53 is the most commonly mutated gene in cancer, and gain-of-function mutations have wide-ranging effects. Efforts to reactivate wild-type p53 function and inhibit mutant functions have been complicated by the variety of TP53 mutations. Identified f
Externí odkaz:
https://doaj.org/article/c07b755597a5468588906ab014a43c40
Autor:
Jian-Guo Zhou, Ada Hang-Heng Wong, Haitao Wang, Su-Han Jin, Fangya Tan, Yu-Zhong Chen, Si-Si He, Gang Shen, Benjamin Frey, Rainer Fietkau, Markus Hecht, Shamus R. Carr, Ruihong Wang, Bo Shen, David S. Schrump, Hu Ma, Udo S. Gaipl
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ImportanceBlood cell count test (BCT) is a robust method that provides direct quantification of various types of immune cells to reveal the immune landscape to predict atezolizumab treatment outcomes for clinicians to decide the next phase of treatme
Externí odkaz:
https://doaj.org/article/0510a79ed4e94420ac663f83d39095e3
Autor:
Arun Rajan, Qiang Dong, Chen Zhao, Abigail Wong-Rolle, Prajan Divakar, Yunhua Zhu, Jyh Liang Hor, Noemi Kedei, Madeline Wong, Desiree Tillo, Elizabeth A Conner, David S Schrump, Chengcheng Jin, Ronald N Germain
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background The lung intratumor microbiome influences lung cancer tumorigenesis and treatment responses, but detailed data on the extent, location, and effects of microbes within lung tumors are missing, information needed for improved prognosis and t
Externí odkaz:
https://doaj.org/article/47f6a90d8eef421d919e4a0c79821c52
Autor:
Anand Singh, Nathanael Pruett, Roma Pahwa, Arushi P. Mahajan, David S. Schrump, Chuong D. Hoang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 669-681 (2021)
Malignant pleural mesothelioma (MPM) is an incurable surface neoplasm with peculiar pathobiology. MPM proliferates by using the tyrosine-kinase-Ras pathway. Despite representing an attractive therapeutic target, there are no standard agent(s) specifi
Externí odkaz:
https://doaj.org/article/61c858b8c4474f5d9fe4638fef37d247
Autor:
Yin Xiong, PhD, Sichuan Xi, PhD, Sudheer Kumar Gara, PhD, Jigui Shan, PhD, James Gao, PhD, Mary Zhang, MS, Vivek Shukla, PhD, Ruihong Wang, PhD, Chuong D. Hoang, MD, Haobin Chen, MD, PhD, David S. Schrump, MD, MBA
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 7, Pp 100181- (2021)
Introduction: Although communal smoking of hookah by means of water pipes is perceived to be a safe alternative to cigarette smoking, the effects of hookah smoke in respiratory epithelia have not been well characterized. This study evaluated epigenom
Externí odkaz:
https://doaj.org/article/873846f098014644911c9514ccac2c84