Zobrazeno 1 - 10
of 31
pro vyhledávání: '"David S, Menaldino"'
Autor:
George W. Koszalka, Kamalesh P. Ruppa, Polina Lyuboslavsky, David S. Menaldino, Raymond Dingledine, Dennis C. Liotta, Stephen F. Traynelis, Zackery W. Dentmon, Lawrence J. Wilson, Scott J. Myers, Robert Zaczek, Yesim Altas Tahirovic
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:41-52
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B-selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c1e8e93e3ee0c58291395f09218349
https://doi.org/10.1124/jpet.120.000370
https://doi.org/10.1124/jpet.120.000370
Autor:
Gary J. Bassell, Pernille Bülow, Dennis C. Liotta, Riley E. Perszyk, Alpa Khatri, Gabriela Fernandez-Cuervo, Pavan Kumar Reddy Gangireddy, Phuong Le, Chris Shelley, Matthew P. Epplin, Lanny S. Liebeskind, Jing Zhang, Ethel C. Garnier-Amblard, David S. Menaldino, Hongjie Yuan, Stephen F. Traynelis, Sharon A. Swanger
Publikováno v:
Nature chemical biology
Allosteric modulators of ion channels typically alter the transitions rates between conformational states without changing the properties of the open pore. We describe here a novel class of positive allosteric modulators of N-methyl D-aspartate recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5e2b889fb5f8bd4fa908708f684e9f
http://europepmc.org/articles/PMC6986806
http://europepmc.org/articles/PMC6986806
Autor:
Anatoliy S. Bushnev, Mark T. Baillie, Jason J. Holt, David S Menaldino, Alfred H. Merrill Jr., Dennis C. Liotta
Publikováno v:
ARKIVOC, Vol 2010, Iss 8, Pp 263-277 (2010)
Externí odkaz:
https://doaj.org/article/9e02da575f2e494a9beae5915b1c7b19
Autor:
Zongjian Zhu, George W. Koszalka, Dennis C. Liotta, Rhonda L. Moore, Steven A. Kell, David S. Menaldino, Stephen F. Traynelis, Scott J. Myers, Samantha L. Summer
Publikováno v:
ACS Medicinal Chemistry Letters. 10:248-254
[Image: see text] The N-methyl-d-aspartate receptor plays a critical role in central nervous system processes. Its diverse properties, as well as hypothesized role in neurological disease, render NMDA receptors a target of interest for the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c559418bdd69a66568a49ad1830a0f2
https://doi.org/10.1021/acsmedchemlett.8b00395
https://doi.org/10.1021/acsmedchemlett.8b00395
Autor:
Jing Zhang, Katie L. Strong, Riley E. Perszyk, Chad R. Camp, Kevin K. Ogden, Timothy J. Wilding, Subhrajit Bhattacharya, Dennis C. Liotta, Miranda J. McDaniel, Stephen F. Traynelis, David S. Menaldino, Pieter B. Burger, Tue G. Banke, Matthew P. Epplin, Hiro Kusumoto, Kasper B. Hansen, James E. Huettner, Phuong Le, Thomas M. Kaiser, Gil Shaulsky
Publikováno v:
ACS Chem Neurosci
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic ligand-gated glutamate receptors that mediate fast excitatory synaptic transmission in the central nervous system (CNS). Several neurological disorders may involve NMDAR hypofunction, which has d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d07e01a657441de0ec746261b2976f2
https://europepmc.org/articles/PMC7967294/
https://europepmc.org/articles/PMC7967294/
Autor:
Scott J, Myers, Kamalesh P, Ruppa, Lawrence J, Wilson, Yesim A, Tahirovic, Polina, Lyuboslavsky, David S, Menaldino, Zackery W, Dentmon, George W, Koszalka, Robert, Zaczek, Raymond J, Dingledine, Stephen F, Traynelis, Dennis C, Liotta
Publikováno v:
J Pharmacol Exp Ther
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B–selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db965d485c48ecef3089d635d22d3940
https://pubmed.ncbi.nlm.nih.gov/34493631
https://pubmed.ncbi.nlm.nih.gov/34493631
Autor:
Lynnea D. Harris, Dennis C. Liotta, Ayush Mohan, Katie L. Strong, Phuong Le, Zongjian Zhu, John Bacsa, Matthew P. Epplin, Stephen F. Traynelis, David S. Menaldino
Publikováno v:
J Med Chem
The N-methyl-d-aspartate receptor (NMDAR) is an ion channel that mediates the slow, Ca(2+)-permeable component of glutamatergic synaptic transmission in the central nervous system (CNS). NMDARs are known to play a significant role in basic neurologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829b6ec2070e82af6a5b7e3d70b242e8
https://europepmc.org/articles/PMC7961853/
https://europepmc.org/articles/PMC7961853/
Autor:
G. Prabhakar Reddy, Randy B. Howard, Richard F. Arrendale, David S. Menaldino, Sarah T. Pruett, Manohar Saindane, Dennis C. Liotta, Mark T. Baillie, Jason J. Holt, Deborah G. Culver, John A. Petros, Eric J. Miller, Michael G. Natchus, Taylor J. Evers, Suzanne G. Mays
Publikováno v:
ACS Medicinal Chemistry Letters. 7:537-542
The orally bioavailable 1-deoxy-sphingosine analog, Enigmol, has demonstrated anticancer activity in numerous in vivo settings. However, as no Enigmol analog with enhanced potency in vitro has been identified, a new strategy to improve efficacy in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f8cc417011a9fe835509db03dfa969
https://doi.org/10.1021/acsmedchemlett.6b00113
https://doi.org/10.1021/acsmedchemlett.6b00113
Autor:
Kasper B. Hansen, Ruth K. Mizu, Stephen F. Traynelis, Gil Shaulsky, David S. Menaldino, Pieter B. Burger, Wenshu XiangWei, Ding Liu, Zongjian Zhu, Scott J. Myers, Weiting Tang, Hongjie Yuan, Feng Yi, Dennis C. Liotta, Samantha L. Summer, Matthew P. Epplin
Publikováno v:
Neuropharmacology
NMDA receptors are ligand-gated ion channels that mediate excitatory neurotransmission. Most native NMDA receptors are tetrameric assemblies of two glycine-binding GluN1 and two glutamate-binding GluN2 subunits. Co-assembly of the glycine-binding Glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d98956388d443249d4f1d2781f433c0
https://doi.org/10.1016/j.neuropharm.2020.108117
https://doi.org/10.1016/j.neuropharm.2020.108117
Autor:
Matthew P. Epplin, Brooke M Katzman, Yesim Altas Tahirovic, David S. Menaldino, Riley E. Perszyk, Stephen F. Traynelis, Hirofumi Kusumoto, Pieter B. Burger, Steven A. Kell, Rhonda L. Moore, Dennis C. Liotta
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
N-methyl-d-aspartate receptors (NMDARs) are an important receptor in the brain and have been implicated in multiple neurological disorders. Many non-selective NMDAR-targeting drugs are poorly tolerated, leading to efforts to target NMDAR subtypes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b919a57d8e8d534ef377876d216651b
https://doi.org/10.7554/elife.34711
https://doi.org/10.7554/elife.34711