Zobrazeno 1 - 10
of 619
pro vyhledávání: '"David S, Klimstra"'
Autor:
Atsushi Tanaka, Makiko Ogawa, Yihua Zhou, Kei Namba, Ronald C. Hendrickson, Matthew M. Miele, Zhuoning Li, David S. Klimstra, Patrick G. Buckley, Jeffrey Gulcher, Julia Y. Wang, Michael H.A. Roehrl
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113810- (2024)
Summary: Metastatic progression of colorectal adenocarcinoma (CRC) remains poorly understood and poses significant challenges for treatment. To overcome these challenges, we performed multiomics analyses of primary CRC and liver metastases. Genomic a
Externí odkaz:
https://doaj.org/article/f4e4d723c6044042aa3cf7bf829ec054
Autor:
Anne M. Schultheis, Ino deBruijn, Pier Selenica, Gabriel S. Macedo, Edaise M. daSilva, Salvatore Piscuoglio, Achim A. Jungbluth, Kay J. Park, David S. Klimstra, Eva Wardelmann, Wolfgang Hartmann, Claus Dieter Gerharz, Mareike vonPetersdorff, Reinhard Buettner, Jorge S. Reis‐Filho, Britta Weigelt
Publikováno v:
Molecular Oncology, Vol 16, Iss 4, Pp 833-845 (2022)
Small cell carcinoma (SCC) of the uterine cervix is a rare and aggressive form of neuroendocrine carcinoma, which resembles small cell lung cancer (SCLC) in its histology and poor survival rate. Here, we sought to define the genetic underpinning of S
Externí odkaz:
https://doaj.org/article/9522e16c4c97404e9c06171446460311
Autor:
Atsushi Tanaka, Julia Y. Wang, Jinru Shia, Yihua Zhou, Makiko Ogawa, Ronald C. Hendrickson, David S. Klimstra, Michael H. Roehrl
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract DEAD-box RNA helicase DDX21 (also named nucleolar RNA helicase 2) is a nuclear autoantigen with undefined roles in cancer. To explore possible roles of autoimmune recognition in cancer immunity, we examined DDX21 protein expression in colore
Externí odkaz:
https://doaj.org/article/c2c9bb8563534cf2977d98f7085af19d
Autor:
Orly Ardon PhD, MBA, Victor E. Reuter MD, Meera Hameed MD, Lorraine Corsale BFA, Allyne Manzo BFA, Sahussapont J. Sirintrapun MD, Peter Ntiamoah PhD, Evangelos Stamelos MS, Peter J. Schueffler PhD, Christine England MBA, David S. Klimstra MD, Matthew G. Hanna MD
Publikováno v:
Academic Pathology, Vol 8 (2021)
Implementation of an infrastructure to support digital pathology began in 2006 at Memorial Sloan Kettering Cancer Center. The public health emergency and COVID-19 pandemic regulations in New York City required a novel workflow to sustain existing ope
Externí odkaz:
https://doaj.org/article/017b8c0e4c0b4a5998bf88c147cdc21d
Autor:
Kazuhiro Tabata, Naohiro Uraoka, Jamal Benhamida, Matthew G. Hanna, Sahussapont Joseph Sirintrapun, Brandon D. Gallas, Qi Gong, Rania G. Aly, Katsura Emoto, Kant M. Matsuda, Meera R. Hameed, David S. Klimstra, Yukako Yagi
Publikováno v:
Diagnostic Pathology, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Background The establishment of whole-slide imaging (WSI) as a medical diagnostic device allows that pathologists may evaluate mitotic activity with this new technology. Furthermore, the image digitalization provides an opportunity to develo
Externí odkaz:
https://doaj.org/article/3288f48a24204df6b00d57d838a52f8d
Autor:
Chang S. Chan, Saurabh V. Laddha, Peter W. Lewis, Matthew S. Koletsky, Kenneth Robzyk, Edaise Da Silva, Paula J. Torres, Brian R. Untch, Janet Li, Promita Bose, Timothy A. Chan, David S. Klimstra, C. David Allis, Laura H. Tang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
In pancreatic neuroendocrine tumors (PanNETs) ATRX, DAXX, and MEN1 are commonly mutated (A-D-M mutant PanNETs). Here, the authors find in a cohort of PanNETS 58% are A-D-M mutant PanNETs, with a worse clinical outcome and differences in gene expressi
Externí odkaz:
https://doaj.org/article/91a16d51722c4f0dab5944814d57ad6b
Autor:
Ammar A, Javed, Alessandra, Pulvirenti, Samrah, Razi, Jian, Zheng, Theodoros, Michelakos, Yurie, Sekigami, Elizabeth, Thompson, David S, Klimstra, Vikram, Deshpande, Aatur D, Singhi, Matthew J, Weiss, Christopher L, Wolfgang, John L, Cameron, Alice C, Wei, Amer H, Zureikat, Cristina R, Ferrone, Jin, He
Publikováno v:
Annals of surgery.
To identify factors associated with concordance between World Health Organization (WHO) grade on cytological analysis (c-grade) and histopathological analysis (h-grade) of surgical specimen in patients with PanNETs and examine trends in utilization a
Autor:
Atsushi Tanaka, Julia Y. Wang, Jinru Shia, Yihua Zhou, Makiko Ogawa, Ronald C. Hendrickson, David S. Klimstra, Michael H. A. Roehrl
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Colorectal cancers are among the most common cancers and a leading cause of cancer death. In our pursuit to discover molecular markers for better characterization and precision theranostics of these cancers, we first conducted global deep proteome an
Externí odkaz:
https://doaj.org/article/8e97bb73fe264c97b8c8ef4100687ea7
Autor:
Atsushi Tanaka, Yihua Zhou, Makiko Ogawa, Jinru Shia, David S Klimstra, Julia Y Wang, Michael H Roehrl
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0229252 (2020)
Proteomic analyses indicate that STAT1 protein (signal transducer and activator of transcription 1 or transcription factor ISGF-3 components p91/p84) is upregulated in some colorectal cancers. This study examined 736 colorectal cancer patients for th
Externí odkaz:
https://doaj.org/article/dd9a71bec7cf4a798b98a908225b9837
Autor:
Travis J. Hollmann, Ingo K. Mellinghoff, Nicholas D. Socci, Andrea Schietinger, Margaret K. Callahan, Fiona Ginty, Elizabeth McDonough, Alex D. Corwin, Stephanie L. Goff, Billel Gasmi, John M. Kirkwood, Jennifer A. Wargo, Raymond Traweek, Michael G. White, Janis M. Taube, Julie E. Stein, Kara M. Schenk, Evan J. Lipson, Thomas Brenn, Claire F. Temple-Oberle, David S. Klimstra, Saad Nadeem, Carl Campos, Subhiksha Nandakumar, Mianlei Zhang, Yanyun Li, Daniel A. Navarrete, Mono Pirun, Zheng Zeng, Charlotte E. Ariyan, Caitlin J. Jones, Maryam Pourmaleki
Cancer immunotherapy can result in lasting tumor regression, but predictive biomarkers of treatment response remain ill-defined. Here, we performed single-cell proteomics, transcriptomics, and genomics on matched untreated and IL2 injected metastases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216f1dd5447158b61cd71a0e6db3b398
https://doi.org/10.1158/2326-6066.c.6550763
https://doi.org/10.1158/2326-6066.c.6550763