Zobrazeno 1 - 10
of 231
pro vyhledávání: '"David S, Bredt"'
Autor:
Madhurima Dhara, Jose A. Matta, Min Lei, Daniel Knowland, Hong Yu, Shenyan Gu, David S. Bredt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Small molecule polyamines participate in diverse aspects of cell growth and differentiation and are known to regulate ion channel gating. Here authors reveal that cellular polyamines control nicotinic acetylcholine receptor (nAChR) biogenesis, and ei
Externí odkaz:
https://doaj.org/article/a4d43b266fe844dd9fdeb0819c48ee18
Autor:
G. Brent Dawe, Hong Yu, Shenyan Gu, Alissa N. Blackler, Jose A. Matta, Edward R. Siuda, Elizabeth B. Rex, David S. Bredt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The α7 nicotinic acetylcholine receptor (nAChR) plays a major role in shaping the activity of neuronal circuits and contributes to the pathophysiology of several neurological disorders. Following cDNA library screening, the authors identify anti-apo
Externí odkaz:
https://doaj.org/article/94a386d702d14777ad23a1ac9956e5a0
Autor:
Hae-Jin Kweon, Shenyan Gu, Emily Witham, Madhurima Dhara, Hong Yu, Elodie Desuzinges Mandon, Anass Jawhari, David S. Bredt
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108025- (2020)
Summary: The α7 nicotinic acetylcholine receptor participates in diverse aspects of brain physiology and disease. Neurons tightly control α7 assembly, which relies upon NACHO, an endoplasmic reticulum (ER)-localized integral membrane protein. By co
Externí odkaz:
https://doaj.org/article/841ce8e290134a80aef0f8d9ed38a998
Autor:
Jose A. Matta, Shenyan Gu, Weston B. Davini, Brian Lord, Edward R. Siuda, Anthony W. Harrington, David S. Bredt
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 688-696 (2017)
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine. Neuronal nAChRs derive from combinations of α and β subunits, whose assembly is tightl
Externí odkaz:
https://doaj.org/article/3133717f13e440569d759f9048cbb811
Autor:
Nadine Erlenhardt, Hong Yu, Kavitha Abiraman, Tokiwa Yamasaki, Jacques I. Wadiche, Susumu Tomita, David S. Bredt
Publikováno v:
Cell Reports, Vol 14, Iss 4, Pp 782-794 (2016)
AMPA receptor (AMPAR) complexes contain auxiliary subunits that modulate receptor trafficking and gating. In addition to the transmembrane AMPAR regulatory proteins (TARPs) and cornichons (CNIH-2/3), recent proteomic studies identified a diverse arra
Externí odkaz:
https://doaj.org/article/31424928f3ca4ecd969e75b3ca3eac5d
Publikováno v:
Science (New York, N.Y.). 373(6556)
The neurotransmitter acetylcholine (ACh) acts in part through a family of nicotinic ACh receptors (nAChRs), which mediate diverse physiological processes including muscle contraction, neurotransmission, and sensory transduction. Pharmacologically, nA
Autor:
Paul L. Ornstein, David S. Bredt, Vanessa N. Barth, Eric S. Nisenbaum, Kar-Chan Choong, Wenhong Guo, Warren J. Porter, Kevin Matthew Gardinier, Emanuele Sher, Yue-Wei Qian, Jon K. Reel, Christian C. Felder, John T. Catlow, Rosa Maria A. Simmons, Kevin D. Burris, Kelly L. Knopp, Douglas Linn Gernert, Chunjin Ding, Steven Swanson, Anne B. Need, Theron M. Wall, He Wang, Akihiko Kato, Douglas A. Schober, Ruud Zwart, Benjamin L. Adams, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:345-363
Nonselective glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists are efficacious in chronic pain but have significant tolerability issues, likely arising from the ubiquitous expression of AMPA receptors in the
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53965 (2013)
Postsynatptic density protein (PSD-95) is a 95 kDa scaffolding protein that assembles signaling complexes at synapses. Over-expression of PSD-95 in primary hippocampal neurons selectively increases synaptic localization of AMPA receptors; however, mi
Externí odkaz:
https://doaj.org/article/cb0fdc4282714bdbb3186b1660ffe58a
Autor:
Kristian Strømgaard, Bernhard Bettler, Louise S. Clemmensen, David S. Bredt, Mette Ishøy Rosenbaum
Publikováno v:
Nature reviews. Drug discovery. 19(12)
Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled receptors, has directly enabled the discovery of most drugs developed to modulate receptor signalling. However, as the search for novel and improved drugs continues,
Autor:
David S. Bredt, Jose A. Matta, Hae-Jin Kweon, Madhurima Dhara, Weston B. Davini, Daniel Knowland, Min Lei O'carroll, Shenyan Gu
Publikováno v:
Proc Natl Acad Sci U S A
Auditory hair cells receive olivocochlear efferent innervation, which refines tonotopic mapping, improves sound discrimination, and mitigates acoustic trauma. The olivocochlear synapse involves α9α10 nicotinic acetylcholine receptors (nAChRs), whic