Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David Rysanek"'
Autor:
Zofia Chrienova, David Rysanek, Josef Novak, Pavla Vasicova, Patrik Oleksak, Rudolf Andrys, Adam Skarka, Jelena Dumanovic, Zoran Milovanovic, Vesna Jacevic, Marketa Chvojkova, Kristina Holubova, Karel Vales, Veronika Skoupilova, Marian Valko, Klaudia Jomova, Suliman Y. Alomar, Fernanda D. Botelho, Tanos C.C. Franca, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115600- (2023)
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s br
Externí odkaz:
https://doaj.org/article/44e7104b724844208bfcb788fd0917db
Autor:
Zofia Chrienova, David Rysanek, Patrik Oleksak, Dorota Stary, Marek Bajda, Milan Reinis, Romana Mikyskova, Ondrej Novotny, Rudolf Andrys, Adam Skarka, Pavla Vasicova, Josef Novak, Martin Valis, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
To date, the most studied drug in anti-aging research is the mTOR inhibitor – rapamycin. Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation – inappropriate physicochemical properties. Therefore, we have dec
Externí odkaz:
https://doaj.org/article/2138141c119d4080852852773bb5684e
Autor:
Patrik Oleksak, Miroslav Psotka, Marketa Vancurova, Olena Sapega, Jana Bieblova, Milan Reinis, David Rysanek, Romana Mikyskova, Katarina Chalupova, David Malinak, Jana Svobodova, Rudolf Andrys, Helena Rehulkova, Vojtech Skopek, Pham Ngoc Lam, Jiri Bartek, Zdenek Hodny, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 410-424 (2021)
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Externí odkaz:
https://doaj.org/article/cfac0c0e4320428ab38cfae14e7c28f8
Autor:
David Rysanek, Pavla Vasicova, Jayaprakash Narayana Kolla, David Sedlak, Ladislav Andera, Jiri Bartek, Zdenek Hodny
Publikováno v:
Aging. 14(16)
Accumulation of senescent cells in tissues with advancing age participates in the pathogenesis of several human age-associated diseases. Specific senescent secretome, the resistance of senescent cells to apoptotic stimuli, and lack of immune system r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f24c5ec3d2fba850b6749cd429a70c
https://pubmed.ncbi.nlm.nih.gov/35951353
https://pubmed.ncbi.nlm.nih.gov/35951353
Autor:
Patrik, Oleksak, Miroslav, Psotka, Marketa, Vancurova, Olena, Sapega, Jana, Bieblova, Milan, Reinis, David, Rysanek, Romana, Mikyskova, Katarina, Chalupova, David, Malinak, Jana, Svobodova, Rudolf, Andrys, Helena, Rehulkova, Vojtech, Skopek, Pham, Ngoc Lam, Jiri, Bartek, Zdenek, Hodny, Kamil, Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::222100201d1b14a99eb79f6b9e1f39ad
https://pubmed.ncbi.nlm.nih.gov/33440995
https://pubmed.ncbi.nlm.nih.gov/33440995
Autor:
David Malinak, Pham Ngoc Lam, Marketa Vancurova, Romana Mikyšková, Vojtech Skopek, Kamil Musilek, Jana Svobodova, Helena Rehulkova, Zdenek Hodny, Miroslav Psotka, Milan Reinis, Olena Sapega, Jiri Bartek, Katarina Chalupova, Rudolf Andrys, David Rysanek, Patrik Oleksak, Jana Bieblová
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 410-424 (2021)
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cac5c92173998608c522cc3e9dc3be
Autor:
Kristýna Merunková, Petr Baldrian, Barbara Doreen Bahnmann, Iñaki Odriozola, Tijana Martinović, Petr Kohout, David Rysanek, Michal Tomšovský, Tereza Mašínová, Petr Sedlák
Publikováno v:
Fungal Ecology. 48:100985
Fungi are key mediators of ecosystem processes in temperate forests. Hence, understanding of fungal community development is central to better understand the mechanisms driving shifts in ecosystem processes during forest succession. We studied fungal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bf0c7593895be793cc62b14fd13cd1a
https://doi.org/10.1016/j.funeco.2020.100985
https://doi.org/10.1016/j.funeco.2020.100985