Zobrazeno 1 - 2
of 2
pro vyhledávání: '"David Ross Goshorn"'
Autor:
Vinay M. Daryani, Amy J. Funk, Cori Bradley, Christopher Calabrese, Amos Hong Pheng Loh, David Ross Goshorn, Armita Bahrami, Clinton F. Stewart, Michael A. Dyer, Xiang Chen, Peter Vogel, Elizabeth Stewart, Asa Karlstrom, Fred Krafcik, Greg Miller, Anang A. Shelat
Publikováno v:
Cancer letters. 442
Lead discovery in osteosarcoma has been hampered by the lack of new agents, limited representative clinical samples and paucity of accurate preclinical models. We developed orthotopic patient-derived xenografts (PDXs) that recapitulated the molecular
Autor:
David Ross Goshorn, Michael W. Bishop, Dana Hawkins, Shenghua Mao, Victor M. Santana, Alberto S. Pappo, Jianrong Wu, Jamie L. Coleman, Sara M. Federico, Michael A. Dyer, Catherine G. Lam, Elizabeth Stewart
Publikováno v:
Journal of Clinical Oncology. 35:10542-10542
10542 Background: Poly (ADP-ribose) Polymerase inhibitors (PARPi) target tumors with deficiencies in DNA repair mechanisms. Talazoparib (TAL), a potent PARP inhibitor, demonstrated significant efficacy in a Ewing sarcoma model when combined with DNA-