Zobrazeno 1 - 10
of 345
pro vyhledávání: '"David Ron"'
Publikováno v:
eLife, Vol 13 (2024)
Activating transcription factor 6 (ATF6) is one of three endoplasmic reticulum (ER) transmembrane stress sensors that mediate the unfolded protein response (UPR). Despite its crucial role in long-term ER stress adaptation, regulation of ATF6 alpha (
Externí odkaz:
https://doaj.org/article/9433481c101a4529abf93bc4343026a9
Autor:
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 3, Pp n/a-n/a (2023)
Abstract Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset diabetes mellitu
Externí odkaz:
https://doaj.org/article/39116a8baac7473c85e71501c8fe0c4e
Autor:
Luke A. Perera, Steffen Preissler, Nathan R. Zaccai, Sylvain Prévost, Juliette M. Devos, Michael Haertlein, David Ron
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The ER chaperone BiP is regulated by FICD-mediated AMPylation and deAMPylation. Here, the authors characterise the structure of mammalian AMPylated BiP bound to FICD, by X-ray crystallography and neutron scattering, providing insights into the mechan
Externí odkaz:
https://doaj.org/article/b1546d211ae74008933f9a4fd1200d65
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109144- (2021)
Summary: Circulating polymers of α1-antitrypsin (α1AT) are neutrophil chemo-attractants and contribute to inflammation, yet cellular factors affecting their secretion remain obscure. We report on a genome-wide CRISPR-Cas9 screen for genes affecting
Externí odkaz:
https://doaj.org/article/46a4f8ba641a46db88d9469383794bcc
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in maintenance of protein folding homeostasis inside the ER has remained unclear. Here the authors determine the structure of the complex between MANF and the ER-localized chapero
Externí odkaz:
https://doaj.org/article/29a9184db10c451b966d07b035dde1b3
Publikováno v:
eLife, Vol 9 (2020)
The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular processes. ER calcium depletion robustly activates t
Externí odkaz:
https://doaj.org/article/2df68a40864044a2966b41fdb69dcf50
Publikováno v:
eLife, Vol 8 (2019)
Coupling of endoplasmic reticulum (ER) stress to dimerisation-dependent activation of the UPR transducer IRE1 is incompletely understood. Whilst the luminal co-chaperone ERdj4 promotes a complex between the Hsp70 BiP and IRE1’s stress-sensing lumin
Externí odkaz:
https://doaj.org/article/6243d75368fa4ac6bb92dcb63e2aed61
Autor:
Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron
Publikováno v:
eLife, Vol 8 (2019)
The eukaryotic translation initiation factor 2α (eIF2α) kinase GCN2 is activated by amino acid starvation to elicit a rectifying physiological program known as the Integrated Stress Response (ISR). A role for uncharged tRNAs as activating ligands o
Externí odkaz:
https://doaj.org/article/a51ed5f0188c4cd88251aec3835f683c
Autor:
Francesco A. Aprile, Emma Källstig, Galina Limorenko, Michele Vendruscolo, David Ron, Christian Hansen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract A major hallmark of Parkinson’s disease (PD) is the presence of Lewy bodies (LBs) in certain neuronal tissues. LBs are protein-rich inclusions, in which α-synuclein (α-syn) is the most abundant protein. Since these inclusions are not pre
Externí odkaz:
https://doaj.org/article/0c38ccc85024480b8c6ce7d146030f9f
Autor:
Eduardo Pinho Melo, Carlos Lopes, Peter Gollwitzer, Stephan Lortz, Sigurd Lenzen, Ilir Mehmeti, Clemens F. Kaminski, David Ron, Edward Avezov
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-15 (2017)
Abstract Background The fate of hydrogen peroxide (H2O2) in the endoplasmic reticulum (ER) has been inferred indirectly from the activity of ER-localized thiol oxidases and peroxiredoxins, in vitro, and the consequences of their genetic manipulation,
Externí odkaz:
https://doaj.org/article/922d71cfe9cb41b1949d315efd61a13f