Zobrazeno 1 - 10
of 72
pro vyhledávání: '"David Rogers, P"'
Autor:
Jinhong Xie, Jeffrey M. Rybak, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Josie E. Parker, Steven L. Kelly, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Triazoles, the most widely used class of antifungal drugs, inhibit the biosynthesis of ergosterol, a crucial component of the fungal plasma membrane. Inhibition of a separate ergosterol biosynthetic step, catalyzed by the sterol C-24 methylt
Externí odkaz:
https://doaj.org/article/5bf67aaf3a334a329c3a9686785bf735
Autor:
Jeffrey M. Rybak, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Ana C. O. Souza, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Josie E. Parker, Steven L. Kelly, Hannah M. Snell, Christina A. Cuomo, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of action of triazoles is through the specific inhibition of
Externí odkaz:
https://doaj.org/article/f05294528fb640d8a22b184dae7ef4b2
Autor:
Bernardo Ramírez-Zavala, Ines Krüger, Sonja Schwanfelder, Katherine S. Barker, P. David Rogers, Joachim Morschhäuser
Publikováno v:
mSphere, Vol 9, Iss 7 (2024)
ABSTRACT Zinc cluster transcription factors (ZCFs) are a family of transcription regulators that are almost exclusively found in the fungal kingdom. Activating mutations in the ZCFs Mrr1, Tac1, and Upc2 frequently cause acquired resistance to the wid
Externí odkaz:
https://doaj.org/article/959ece019a014963bd83a4e42dfb6f10
Autor:
Bernardo Ramírez-Zavala, Anna Hoffmann, Ines Krüger, Sonja Schwanfelder, Katherine S. Barker, P. David Rogers, Joachim Morschhäuser
Publikováno v:
mSphere, Vol 9, Iss 7 (2024)
ABSTRACT The adaptation of gene deletion methods based on the CRISPR-Cas9 system has facilitated the genetic manipulation of the pathogenic yeast Candida albicans, because homozygous mutants of this diploid fungus can now be generated in a single ste
Externí odkaz:
https://doaj.org/article/e514b24a1a9d4199ac7bc328f8d87fb0
Publikováno v:
Ecological Indicators, Vol 155, Iss , Pp 111067- (2023)
Unrestricted cattle access to the riparian zone can exacerbate riverbank erosion in grazed grassland catchments. Knowledge gaps include the magnitude of erosion and other environmental pressures at cattle access points. This study aimed to address th
Externí odkaz:
https://doaj.org/article/995328c1e7dd49f6917adeda2c452729
Autor:
Alex David Rogers, Hannah Appiah-Madson, Jeff A. Ardron, Nicholas J. Bax, Punyasloke Bhadury, Angelika Brandt, Pier-Luigi Buttigieg, Olivier De Clerck, Claudia Delgado, Daniel L. Distel, Adrian Glover, Judith Gobin, Maila Guilhon, Shannon Hampton, Harriet Harden-Davies, Paul Hebert, Lisa Hynes, Miranda Lowe, Sandy MacIntyre, Hawis Madduppa, Ana Carolina de Azevedo Mazzuco, Anna McCallum, Chris McOwen, Tim Wilhelm Nattkemper, Mika Odido, Tim O’Hara, Karen Osborn, Angelique Pouponneau, Pieter Provoost, Muriel Rabone, Eva Ramirez-Llodra, Lucy Scott, Kerry Jennifer Sink, Daniela Turk, Hiromi Kayama Watanabe, Lauren V. Weatherdon, Thomas Wernberg, Suzanne Williams, Lucy Woodall, Dawn J. Wright, Daniela Zeppilli, Oliver Steeds
Publikováno v:
Frontiers in Marine Science, Vol 10 (2023)
Ocean Census is a new Large-Scale Strategic Science Mission aimed at accelerating the discovery and description of marine species. This mission addresses the knowledge gap of the diversity and distribution of marine life whereby of an estimated 1 mil
Externí odkaz:
https://doaj.org/article/7276b3c9cf5c431d9f037e0652860dc9
Autor:
Anna Serra-Llobet, John Radke, G. Mathias Kondolf, Larry Gurrola, J. David Rogers, Sarah Lindbergh, Johnny Douvinet
Publikováno v:
Frontiers in Environmental Science, Vol 11 (2023)
Historical information about floods is not commonly used in the US to inform land use planning decisions. Rather, the current approach to managing floods is based on static maps derived from computer simulations of the area inundated by floods of spe
Externí odkaz:
https://doaj.org/article/29bdb67a3c3a4f61add15ea1afb758af
Autor:
Ana C. O. Souza, Wenbo Ge, Nathan P. Wiederhold, Jeffrey M. Rybak, Jarrod R. Fortwendel, P. David Rogers
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Aspergillus fumigatus is a ubiquitous environmental mold that can cause severe disease in immunocompromised patients and chronic disease in individuals with underlying lung conditions. Triazoles are the most widely used class of antifungal d
Externí odkaz:
https://doaj.org/article/8a734e7ad5d14bd298a1db6bfd409309
Publikováno v:
In Current Opinion in Microbiology December 2022 70
Autor:
Katherine Meese, Alejandra Colón-López, Aoyjai Montgomery, Laurence Boitet, David Rogers, Patricia Patrician
Publikováno v:
Patient Experience Journal, Vol 9, Iss 2 (2022)
The objective of this study is to examine the incidence of reported stress due to mistreatment by patients toward clinicians and the role of mistreatment from patients along with organizational factors in clinician distress. A survey of clinicians wa
Externí odkaz:
https://doaj.org/article/516f2182af8146f1b6fa2382c1fa9b2c