Zobrazeno 1 - 10
of 72
pro vyhledávání: '"David Robert Grimes"'
Autor:
David Robert Grimes
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-5 (2024)
Abstract High-quality cancer research is crucial to both save lives and improve quality of life. Spurious findings, however, impedes these laudable goals by misleading research efforts and creating research waste that is inherently difficult to count
Externí odkaz:
https://doaj.org/article/958598df06e14c06ad7ffb71a79b1568
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology. Disparities in treatment outcomes between male and female cancer pat
Externí odkaz:
https://doaj.org/article/ef4964139bd14a4fb88879a64b10a243
Autor:
Mengqi Li, Declan Devane, Claire Beecher, Maura Dowling, Austin G. Duffy, Caitriona Duggan, David Robert Grimes, Avril Kennan, Claire Kilty, Allen Nsangi, Andrew D. Oxman, Derek C. Stewart, Elaine Toomey, Marie Tierney
Publikováno v:
PEC Innovation, Vol 5, Iss , Pp 100311- (2024)
Objective: The overabundance of health misinformation has undermined people's capacity to make evidence-based, informed choices about their health. Using the Informed Health Choices (IHC) Key Concepts (KCs), we are developing a two-stage education pr
Externí odkaz:
https://doaj.org/article/77e666dcfffd429fb64fe8b21f11363e
Autor:
David Robert Grimes
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Objective Cervical screening is a life-saving intervention, which reduces the incidence of and mortality from cervical cancer in the population. Human papillomavirus (HPV) based screening modalities hold unique promise in improving screening accuracy
Externí odkaz:
https://doaj.org/article/5e39afae4f5341bfa8aae7cdef6d810c
Autor:
David Robert Grimes
Publikováno v:
eLife, Vol 13 (2024)
In biomedical science, it is a reality that many published results do not withstand deeper investigation, and there is growing concern over a replicability crisis in science. Recently, Ellipse of Insignificance (EOI) analysis was introduced as a tool
Externí odkaz:
https://doaj.org/article/71424aa0ea154b669ce6930eea529d73
Autor:
David Robert Grimes
Publikováno v:
Royal Society Open Science, Vol 11, Iss 1 (2024)
The reality that volumes of published biomedical research are not reproducible is an increasingly recognized problem. Spurious results reduce trustworthiness of reported science, increasing research waste. While science should be self-correcting from
Externí odkaz:
https://doaj.org/article/700b034d2b524712a50d0f3fb9a692b7
Autor:
David Robert Grimes, James Heathers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/78624cd082594ab29264b3d1717645fb
Autor:
David Robert Grimes
Publikováno v:
eLife, Vol 11 (2022)
There is increasing awareness throughout biomedical science that many results do not withstand the trials of repeat investigation. The growing abundance of medical literature has only increased the urgent need for tools to gauge the robustness and tr
Externí odkaz:
https://doaj.org/article/486ddc6b396e48a89bdd49af2fc05e9c
Autor:
Robert O’Connor, Andrew D. Oxman, Marie Tierney, Claire Beecher, Derek C. Stewart, Mengqi Li, Caitriona Duggan, Austin G. Duffy, Maura Dowling, Avril Kennan, David Robert Grimes, Allen Nsangi, Declan Devane, Sarah McLoughlin, Elaine Toomey
Publikováno v:
HRB Open Research, Vol 5 (2022)
Background: Few areas of health have been as insidiously influenced by misinformation as cancer. Thus, interventions that can help people impacted by cancer reduce the extent to which they are victims of misinformation are necessary. The Informed Hea
Externí odkaz:
https://doaj.org/article/6d83dce25a0344fdb83ecbb0b7140f50
Autor:
David Robert Grimes, James Heathers
Publikováno v:
Royal Society Open Science, Vol 8, Iss 12 (2021)
A concerning amount of biomedical research is not reproducible. Unreliable results impede empirical progress in medical science, ultimately putting patients at risk. Many proximal causes of this irreproducibility have been identified, a major one bei
Externí odkaz:
https://doaj.org/article/63eed035398243f2bf1ef5acb8ce3073